Noriyuki Sagara

The follow up study of intra-arterial infusion chemotherapy with local vein blocking as a surgical neo-adjuvant treatment for locally advanced breast cancer.

Preoperative intra-arterial infusion neo-adjuvant chemotherapy, in combination with local vein blocking, was administered to thirtyone patients with locally advanced stage III breast cancer. The anti-cancer drugs and dosages used were 500 mg of 5-Fluorouracil (5FU), which was infused daily for 7–14 days, and 20 mg of Adriamycin (ADM), which was administered as a bolus dose twice into the subclavian and internal mammary arteries. The response rate of this method on the primary tumor was 48.4 per cent, and, histologically it was found to be as high as 90.3 per cent. The response rate of the clinical effects on the regional lymph nodes was 50.0 per cent, however, histologically, it was found to be lower than that of the primary tumor. In the long-term follow up study the 5-year survival rate was 72.2 per cent. Thus, this method seems to be effective as a combined modality in cases of locally advanced stage III breast cancer.

Characterization and Metastatic Potential of a Mouse Adenocarcinoma Cell Line XK-4 which arose in Nude Mouse during the Transplantation of Human Colon Cancer Cell Line KUMRK-4N.

新しい腺癌肝転移モデルを樹立した.1985年10月に当院で手術した直腸癌組織をヌ-ドマウスの背部に移植し, ヒト大腸癌細胞株KUM・RK-4Nを樹立し以後継代した-1990年2月にこの腫瘍より初代培養を行い培養細胞株を樹立した.この細胞をヌードマウスに尾静脈注入および前腸間膜静脈より注入したところ, 約2-3週間で肺および肝臓に明瞭な結節型の転移巣を生じた.ヒト癌でのヌ-ドマウスにおける転移はまれであり, この培養細胞の染色体分析およびアイソザイム分析ではマウス由来の癌と考えられ, また胸腺正常同系マウスへの移植は拒絶されたため, ヌードマウス由来腺癌と考えXK-4細胞と名ずけた.今回, このXK-4細胞の生物学的特性と肺および肝臓への転移能を検討した.