Norman Plummer

Absorption and Excretion of Sulfadiazine.

Summary 1. Sulfadiazine was rapidly absorbed into the blood stream and comparatively high levels of total drug were reached. 2. The proportion of conjugated sulfadiazine in the blood was small. 3. The blood level falls rather slowly after the drug is discontinued. 4. Most of the drug is excreted by the kidney. 5. In 4 patients given 2 g of sulfadiazine and in 8 patients given a total of from 7 to 16 g the only toxic reaction noted was a morbilliform rash in one case in the latter group.

SULFADIAZINE AND SODIUM SULFADIAZINE: A COMPARISON OF CERTAIN OF THEIR CLINICAL AND PHARMACOLOGIC VALUES

Excerpt Sulfadiazine (2-sulfanilamido-pyrimidine) and sodium sulfadiazine are following sulfathiazole and sodium sulfathiazole in experimental and clinical trial just as these thiazole derivatives ...

MEDICAL SIGNIFICANCE OF ILLNESS AND ABSENCE IN AN INDUSTRIAL POPULATION

Excerpt It is a fact that the practicing physician spends most of his time taking care of the sick person and, as a result, often knows very little about the well person. In medicine in industry, t...

GLUCOSE-SULFAPYRIDINE; EXPERIMENTAL AND CLINICAL STUDIES

Excerpt When satisfactory oral therapy with sulfapyridine is impossible, or when it is desired rapidly to obtain high blood concentrations of the drug, parenteral administration is necessary. Sodiu...