Norman S. Olsen

Effect of Certain Amines on the Blood Pressure of Normotensive and Hypertensive Rats.

Summary The pressor response of various amines in anesthetized normotensive and hypertensive rats have been studied. The two groups of animals responded differently to different amines. Whereas phenethylamine and tyramine elicited the same degree of elevation of blood pressure in normotensive and hypertensive rats, arterenol and epinephrine caused greater responses and isoamylamine effected much smaller responses in the hypertensive animals.

Pressor Substances in Arterial Hypertension IV. Quantitative and Qualitative Studies of Pherentasin

Pherentasin is the only pressor substance found in blood of hypertensive patients which is not found in normal blood. This study defines its unit and compares its concentration with diastolic blood pressure level, type of hypertension, and age of patients. Lack of correlation between blood pressure level and pherentasin content suggests considerable variation in the amount of depressor substances in these patients. Chemical studies of pherentasin and its partial, tentative formula are discussed. Demonstration of the existence of an additional pressor fraction from blood which is volatile in alkaline solution is described.