Nuran Kahriman

Antimicrobial activity and a comparative essential oil analysis of Centaurea pulcherrima Willd. var. pulcherrima extracted by hydrodistillation and microwave distillation.

The essential oils of Centaurea pulcherrima Willd. var. pulcherrima (Asteraceae) were isolated by hydrodistillation (HD) and a microwave distillation (MD), than characterised by GC-FID and GC-MS. A total of 58 and 57 compounds were identified, constituting over 93.7%, and 91.6% of volatile oil composition of C. pulcherrima var. pulcherrima, respectively. Sesquiterpene hydrocarbons were shown to be the main group of constituents (HD: 42.4% versus MD: 51.5%). The major component of the oils of C. pulcherrima var. pulcherrima was germacrene D (HD, 17.8% versus MD, 23.2%). The antimicrobial activity of the isolated essential oils of the plant was also investigated, and they showed good antibacterial activity against to tested Gram-positive bacteria, especially to M. smegmatis and a yeast-like fungus C. albicans.

Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities.

New 3,5‐disubstituted‐2‐pyrazoline derivatives (4–6), their boron‐fluorine complexes (boron (3‐(2′‐aminophenyl),5‐(2′‐/3′‐/4′‐pyridyl)pyrazoline, BOAPPY) (7–9) and boron 1,2′‐diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1–3) to diazaflavone (10), respectively. Biological evaluation of compounds 4–9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4–9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7–150 μg/mL.