Nurper Onuk Filiz

Effect of n-butyl-2-cyanoacrylate on high-risk colonic anastomoses.

We investigated the effect of n‐butyl‐2‐cyanoacrylate (BCA) on colonic anastomosis under clean contaminated procedure (CCP) and bacterial peritonitis (BP) conditions in rats. Male Wistar albino rats (n = 80) were divided into two groups: CCP and BP. In the CCP group, colonic resection and anastomosis were performed. BP was induced by cecal ligation and puncture. BCA was administered to the anastomosis in half of the rats in both groups. Anastomotic assessment was done on postoperative days 3 and 7 by evaluating the burst pressure, and gross anastomotic and histopathologic healing indices. The presence and severity of adhesion formation was also investigated. There were no differences in terms of gross healing parameters on days 3 and 7. Burst pressures were also similar on both days (p = 0.244 and p = 0.101, respectively). In the early phase (day 3), adhesion development (p < 0.001), granulocytic cell infiltration (p = 0.02), inflammation (p = 0.019) and necrosis (p = 0.019) were higher in the BCA groups. Mononuclear cell infiltration (p = 0.659), fibroblastic cell infiltration (p = 0.538) and capillary formation (p = 0.316) were similar. In the late phase (day 7), adhesion development (p < 0.001), necrosis (p = 0.001) and granulocytic cell infiltration (p = 0.034) were higher in the treatment groups. Fibroblastic cell infiltration (p = 0.017) and capillary formation (p = 0.016) were lower in BCA treated rats, particularly in the BP condition. Mononuclear cell infiltration did not differ (p = 0.176). The application of BCA did not provide any benefit under either CCP or BP conditions. Moreover, BCA caused increased inflammatory reactions, necrosis and adhesion formation. During the late phase of healing, the ongoing enhanced inflammation caused a reduction in capillary formation and fibroblastic infiltration, particularly under BP conditions.

Eccrine angiomatous hamartoma of the fingers with nail destruction

and fibrosis (with increased fibroblast chemotaxis, proliferation and collagen synthesis) in SSc and of fibrosis in sarcoidosis. Increased plasma, BAL and urine levels of endothelin-1 have been reported to be correlated with disease activity in patients with sarcoidosis. Our data indicate that sarcoidosis-related increased blood levels of endothelin-1 may have played a role in the deterioration of vascular clinical manifestations in our patient with lcSSc: following treatment, our patient concomitantly exhibited improvement of SSc-related vascular clinical manifestations and decreased plasma levels of endothelin-1. Finally, the present case also underscores that bosentan is a useful therapy in complicated Raynaud’s phenomenon (with digital ischaemic ulcers) in SSc, as our patient exhibited resolution of multiple fingertip ulcers after institution of bosentan therapy; our findings are in accordance with those of Korn et al. who found a 48% reduction in the mean number of new digital ulcers in patients under bosentan. Because our patient also showed improvement of sarcoidosis (as evidenced by PFT and CT scans of the lungs), we further suggest that bosentan may be useful in management of pulmonary sarcoidosis; although these data remain to be confirmed, this finding is of particular interest as high-dose corticosteroids (>15 mg daily) are not a safe therapy for sarcoidosis in SSc, and may result in increased risk of SSc-related onset of renal crisis. Several clinical trials are currently under way to evaluate the efficacy of bosentan in pulmonary fibrosis.

Intranodal Palisaded Myofibroblastoma; a Case Report and Review of the Literature

Intranodal palisaded myofibroblastoma (IPM) also called as intranodal hemorrhagic spindle cell tumor with amianthoid fibers is a distinctive and rare mesenchymal neoplasm of lymph nodes. This entity generally misdiagnosed as intranodal Kaposi’s sarcoma or schwannoma in past. In contrast to Kaposi’s sarcoma, it behaves in a benign fashion and does not need any further therapy except total surgical resection of the mass. This neoplasm has a great predilection for the inguinal region. The lesion presents typically as a unilateral, painless, solitary mass. To our knowledge, approximately 53 cases of IPM have been reported in the English-language literature. We present a 43-year-old-male patient with IPM and discuss histological, immunohistochemical features and pathogenesis of this rare benign neoplasm.

Experimentally induced acute sinusitis and efficacy of vitamin A

Conclusions. Although antibiotics are the mainstays for treatment of sinusitis, they do not specifically treat tissue damage due to free radicals. We propose that antioxidant, anti-infective, immunomodulator vitamin A may be a useful addition in the management of sinusitis. Objectives. Acute sinusitis is one of the most common diseases in humans. Vitamin A is a fat-soluble vitamin and essential for immunity, cellular differentiation, and maintenance of respiratory and gastrointestinal epithelial surfaces, growth, reproduction, and vision. The objective of this study was to investigate the therapeutic role of vitamin A on healing of acute sinusitis. Materials and methods. This was a prospective controlled animal trial. Experimental sinusitis was induced by blocking the right nose and inoculating Streptococcus pneumoniae into the right maxillary sinuses. Left maxillary sinuses were used as controls. Rabbits were divided in to two groups. At 48h after inoculation, group I received only parenteral ampicillin-sulbactam (50mg/kg), group II was treated with parenteral ampicillin-sulbactam (50mg/kg) and parenteral a dose of 100000 IU vitamin A in palmitate form. All animals were sacrificed on the 10th day. Mucosal samples were excised from the infected and control sinuses for histopathologic examination, for measurement of activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), and for evaluation of levels of malondialdehyde (MDA) and nitric oxide (NO). Results. All the infected sinuses displayed signs of inflammation, but there was no statistically significant difference between the study and control groups. In our study, epithelial integrity as well as NO and MDA levels were better in the group receiving both antibiotic and vitamin A than the group receiving antibiotic alone. Nevertheless, SOD activity was significantly increased in the group receiving only antibiotics, compared with the control mucosal SOD activity. There was no difference between the groups as regards CAT and GSH activity.

Angiolymphoid hyperplasia with eosinophilia mimicking Bowenoid papulosis

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign condition of unknown aetiology characterized by single or multiple brown-red nodules or plaques, usually occurring in the head and neck region, with a reported predilection for the retroauricular area. ALHE is considered to be a vascular proliferative disease, with marked proliferation of blood vessels lined by ‘‘hobnail’’ endothelial cells in conjunction with a dense inflammatory infiltrate mainly composed of eosinophils and lymphocytes. Involvement of the inguinal region is exceedingly rare, with only a few cases reported in the literature involving the penis, inguinal folds and vulvae. In this report, we describe an unusual case of ALHE, presenting with hyperpigmented brownish to pink plaques on the inguinal folds, scrotum and perineal area, masquerading as Bowenoid papulosis.

Adenocarcinoma Originating from a Mature Teratoma of the Testis

Malignant transformation in testicular teratomas has been reported very rarely in the literature. Although testicular teratomas in childhood are regarded as benign neoplasms, these tumors, if left untreated until advanced ages, may present the risk of malignant transformation. We report a case of differentiated adenocarcinoma originating from colonic glands in primary testicular teratoma.

Hyperpigmented mycosis fungoides: a case report

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Coexistence of sacral dimple, solitary collagenoma and mid‐dorsal hypertrichosis in a child with occult spinal dysraphism

blood complement C1 inhibitor activity. Clin Chim Acta 1988; 174:121–30. 6 Drouet C, Blanch A, Roche O et al. Mutation analysis of the C1NH gene. J Allergy Clin Immunol 2004; 114:S66–74. 7 Cichon S, Martin L, Hennies HC et al. Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III. Am J Hum Genet 2006; 79:1098–103. 8 Farsetti A, Misiti S, Citarella F et al. Molecular basis of estrogen regulation of the Hageman factor XII gene expression. Endocrinology 1995; 136:5076–83.

Effect of Chronic Prostatitis on Angiogenic Activity and Serum Prostate Specific Antigen Level in Benign Prostatic Hyperplasia

The aim of this study was to evaluate the effect of chronic inflammatory pathology on the angiogenic activity in benign prostatic hyperplasia (BPH). Besides the presence of a relationship between serum prostate specific antigen (PSA) values and microvessel density (mvd), the intensity and extent (widespread or focal) of tissue PSAexpression was also examined. The distribution of 30 cases according to the diagnosis groups was as follows: group 1, nine cases with prostatic adenocarcinoma; group 2, 10 cases with BPH and chronic prostatitis; group 3, 11 cases with BPH. The biopsy materials obtained by tru‐cut biopsy (five cases) and transurethral resection (25 cases) were evaluated retrospectively. The evaluation of angiogenesis was made by CD34 immune marker, while the analysis of immunohistochemical tissue PSA expression was verified by PSA immune marker. Serum PSA levels and other clinical parameters were obtained from the clinical files of the patients. The mean age of the patients was 68 ± 3 years (range, 48–83 years). The difference between the mean mvd values of the groups was statistically significant (χ2 = 10.492, p = 0.005). Group 1 showed higher mean mvd value than the other two groups. Although group 2 showed higher mean mvd value than group 3, the difference was not statistically significant (p = 0.863). There was no correlation between the mean mvd and serum PSA levels in any group. The intensity of PSA expression in prostate specimens was different in all groups. Maximum cases in group 3 showed high tissue PSA expression (χ2 = 12.442, p = 0.014). In group 1, there was a significant relationship between the intensity of PSA expression and the mean mvd (U = 1, p = 0.032). In group 2, a statistically significant correlation was noted between the mean serum PSA levels and the widespread occurrence of PSA expression (U = 0, p = 0.017). In the present study, we determined that chronic prostatitis had no effect on mvd in BPH cases. The correlation between tissue PSA expression and mvd was contradictory to the reports in the literature. Analyses in larger series are needed to prove the presence of a probable effect of chronic prostatitis on angiogenesis.

Coexistence of lichen aureus with familial Mediterranean fever

© 2007 The Authors 1001 JEADV 2007, 21, 977–1010 Journal compilation