O. Andrée Larsen

Blood flow through human adipose tissue during lipolysis

Nielsen, S. L., Bitsch, V., Larsen, O. A., Lassen, N. A. & Quaade, F. Blood flow through human adipose tissue during lipolysis. Scand. J. clin. Lab. Invest. 22, 124-130, 1968. The influence of lipolysis on the adipose tissue blood flow measured with the 133Xe clearance technique has been examined. In seven subjects norepinephrine was infused intravenously during 30-40 minutes in a dose of 5-10 μg/min. The adipose tissue blood flow (FBF) increased in all patients, from an average of 1.7 ml/100 mg·min before to a maximum average value of 4.5 ml/100 g·min during the infusion. In eleven subjects 5 mg glucagon was injected intravenously during the measurement. In nine of these cases an increase in flow was seen: the average value for the whole group was 2.3 ml/100 g·min before and 3.4 ml/100 g·min after the glucagon injection. Four very obese females were treated with total fasting for 96 hours. In this period the patients had an average weight loss of 6.3 kg and the average prefasting and fasting FBF values w...

Studies of the Bodyhematocrit Phenomenon: Dynamic Hematocrit of a Large Vessel and Initial Distribution Space of Albumin and Fibrinogen in the Whole Body

Larsen, O. A. Studies of the Bodyhematocrit Phenomenon: Dynamic Hematocrit of a Large Vessel and Initial Distribution Space of Albumin and Fibrinogen in the Whole Body. Scand. J. clin. Lab. Invest. 22, 189-195, 1968.By measuring the mean circulation times of 125I-labelled albumin and 51Cr-labelled red cells from the femoral vein to the pulmonary artery it has been shown that the dynamic hematocrit of this vascular area is 99 per cent of the hematocrit determined by centrifugation of a venous blood sample. It is therefore possible for all practical purposes to regard the centrifuge hematocrit as equal to the dynamic hematocrit in a large vessel.The distribution volume of T-1824 and 131I-labelled fibrinogen has been determined simultaneously in 10 patients. T-1824 space exceeded fibrinogen space by 6.4 per cent. The explanation for the difference between the bod yhematocrit and the large vessel hematocrit appear to a major degree to be due to a low intravascular hematocrit caused by a more rapid passage of ...

Paradoxical Effect On Peripheral Blood Flow After Sympathetic Blockades in Patients With Gangrene Due To Arteriosclerosis Obliterans

From the Departments of Clinical Physiology and Anesthesiology, Bispebjerg Hospital, Copenhagen, Denmark. The literature on the effect of vasodilating procedures in the treatment of arterial occlusions is extensive, but the question still remains controversial as both blood flow increases and paradoxical blood flow decreases have repeatedly been reportedl-5. In his recent comprehensive review of the subject, StrandneSS6 is not able to reach a definite conclusion. All authors agree that increased skin blood flow is obtained at rest in patients without arterial obstruction and also in those with mild degrees of arterial obstruction, and it is in the patients with severe arterial obstructions that the disagreement arises. Some authors maintain that vasodilating procedures are contraindicated in severe cases as a paradoxical blood flow reduction will be the result, due to blood &dquo;steal&dquo; in proximal skin and musclesl 7. In contrast to this, other authors disregard the somewhat sparse observations sofar published of paradoxical flow reduction. They maintain that even in the most severe cases of arterial obstruction vasodilating procedures, in particular in the form of lumbar sympathectomy, should be tried, if vascular reconstructive surgery is not possible8. The purpose of the present investigation was to evaluate the effect on distal

The Hematocrit of the Lower Extremity in Man at Rest and during Exercise

The aim of the present work was to study to what extent the vascular area of the leg contributes to the body hematocrit phenomenon, i.e. the fact that the total body hematocrit (hctbody) is about 10% lower than the large vessel hematocrit (hctl.v.).The hematocrit of the leg (hctleg) was calculated from the mean circulation times of plasma and red cells through the vascular bed of the lower extremity. These values were determined at rest and during exercise by the arteriovenous equilibration technique after injection of 125I-labelled albumin and 51Cr-labelled red cells into an antecubital vein and sampling from a peripheral artery and the femoral vein.In 14 normal resting subjects the average hctleg was 90.2% and hctbody 86.9% of hctl.v.. Hctleg was significantly higher than hctbody. During exercise hctleg was also found to be significantly lower than hctl.v. and higher than hctbody, but the ratio between hctleg and hctl.v. was not significantly lower during exercise than during rest.It is concluded that t...