O. Basaran
Başkent University
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Featured researches published by O. Basaran.
Journal of Burn Care & Research | 2006
Altug Kut; O. Basaran; Turgut Noyan; I.Serdar Arda; H Seval Akgün; Mehmet Haberal
This retrospective study analyzed risk factors in addition to the demographic and epidemiological features of 813 burn patients who were admitted to the burn units of a University Hospital Network in Turkey during a 6-year period. The study consisted of 436 men (53.6%) and 377 women (46.4%; mean age, 31; range, 0–87 years). The age distribution of the patients peaked at 1 to 6 years and at 35 to 44 years. The most common types of burns were scalds (63.8%) and flame burns (22.1%). The mean TBSA burned was 9.4 ± 15.3% in adults and 19.8 ± 18.6% in children. The median and mean hospital stays were 16 and 22.8 days, respectively (range, 1–114 days). A total of 813 patients were evaluated, leaving only 255 hospitalized patients. Of the hospitalized patients, 100 (74.6%) underwent autografting, 8 (6.0%) underwent amputation, 113 (84.3%) underwent débridment, and 76 (56.7%) underwent escharotomy. The mortality rate among hospitalized patients was 14.1%. Although this study provides information about the population within close proximity to our burn units, there remains a need for a countrywide database of burn incidents.
Transplantation Proceedings | 1999
R Emiroğlu; O. Basaran; S. Pehlivan; Fatma Nurhan Ozdemir; T. Colak; Gokhan Moray; Turgut Noyan; Mehmet Haberal
Amyloidosis is characterized by the accumulation of an amorphous material in various organs and tissues secondary to a variety of inflammatory, immune, infectious, and hereditary diseases. Since 1975, our transplantation team has performed 1470 renal transplantations. Between 1985 and July 2004, among 1159 kidney transplantations, 953 (82.3%) were from living donors and 206 (17.7%) from cadaveric donors. There were 32 recipients (28 men, 4 women; mean age, 31.4 +/- 1.7 years; range, 21 to 48 years) with amyloidosis, including, 28 (87.5%) who received grafts from living donors and 4 (12.5%) from cadaveric donors. Amyloidosis was secondary to familial Mediterranean fever in 22 (68.7%) patients and rheumatoid arthritis in 1 (3.1%). The remaining 9 (28.1%) patients had primary amyloidosis. The mean follow-up time was 51.2 +/- 5.7 months (range, 2-124 months). Mean HLA mismatch rate was 2.2 +/- 1. Twenty-six (81.2%) patients are alive at this time with functioning grafts, and a mean serum creatinine value of 2.1 +/- 1.5 ng/dL. The 1- and 5-year patient and graft survival rates were 90.6% and 84.3%, and 81.2% and 68.7%, respectively. We conclude that patients with amyloidosis may undergo kidney transplantation safely expecting outcomes similar to those patients who receive transplantations for other reasons.
Journal of Burn Care & Research | 2006
A. Ebru Sakallioglu; O. Basaran; H. Karakayali; B. Handan Ozdemir; Muammer Yucel; Z. Arat; Mehmet Haberal
This study aimed to clarify the local and systemic immune responses at different burn depths. Thirty female Sprague–Dawley rats were divided into three groups: full-thickness (F), partial-thickness (P), and Sham (S). Burns were induced on three separate areas on the dorsums of rats. Serum levels of interferon (IFN)-&ggr;; tumor necrosis factor-&agr;; interleukin (IL)-1, IL-6, and IL-10 were measured once in controls and 1 hour after burn, 48 hours after burn, and 7 days after burn in F and P groups. Neutrophils, CD68-positive macrophages, HLA-DR-positive cells, and CD3-positive lymphocytes were graded semiquantitatively, and the wounds were examined once in shams and at 1 hour after burn, 48 hours after burn, and 7 days after burn in F and P groups. IL-6 levels were highest in F group, followed by P group 1 hour after burn. IFN-&ggr; levels were higher in the F group; IL-1 levels were higher in F and P groups at 1 hour after burn. Local accumulation of macrophages was similar in F and P groups. Lymphocytes were denser in P group at 1 hour after burn, and neutrophils were denser in F group at 7 days after burn. We suggest that early elevations of IL-6 and IFN-&ggr; prolong inflammation in full-thickness burns. Modulation of proinflammatory cytokines may improve burn wound treatment.
International Surgery | 2013
Hakan Yabanoglu; O. Basaran; Cem Aydogan; Özlem Kurt Azap; Feza Karakayali; Gokhan Moray
The aim of this study was to compare the effects of four different topical antimicrobial dressings on a multi-drug resistant Pseudomonas aeruginosa contaminated full-thickness burn wound rat model. A total of 40 adult male Wistar albino rats were used. The control group (group 1), silver sulfadiazine (1%) group 2, chlorhexidine acetate (0.5%) group 3, citric acid (3%) group 4, and silver-coated dressing group 5 were compared to assess the antibacterial effects of a daily application to a 30% full-skin thickness burn wound seeded 10 minutes earlier with 10(8) CFU (colony forming unit)/0.5 mL of a multi-drug resistant Pseudomonas aeruginosa strain. Five groups (1 control group and 4 treatment groups) were compared. The administration of third-degree burns to all rats was confirmed based on histopathologic data. The tissue cultures from groups 2 and 5 exhibited significant differences compared to those of the other 3 groups, whereas no significant differences were observed between groups 1, 3, and 4. The effectiveness of the treatments was as follows: 1% silver sulfadiazine > silver-coated dressing > 3% citric acid > 0.5% chlorhexidine acetate > control group. Our results supported the efficacy of topical therapy by silver sulfadiazine and silver-coated dressing on infections caused by multi-drug resistant Pseudomonas spp.
Journal of Investigative Surgery | 2007
O. Basaran; F. Belgin Ataç; Feza Karakayali; Ibrahim Aliosmanoglu; Mahmut Can Yağmurdur; Fatma Nurhan Ozdemir; Mehmet Haberal
Vascular access thrombosis is a leading cause of vascular access failure in hemodialysis patients. Thrombosis is a multifactorial condition and genetic makeup can affect thrombosis risk. We conducted a study to investigate for possible associations between ecNOS gene intron 4 variable-number tandem repeat (VNTR) polymorphism and thrombosis of polytetrafluoroethylene hemodialysis arteriovenous access grafts (AVG) in Turkish patients. Fifty-five patients with end-stage renal disease who had AVGs implanted between 2000 and 2002 and 167 healthy individuals representing our healthy population were enrolled in this prospective study. Each subject provided a venous blood sample from which DNA was isolated, and polymerase chain reaction analysis was done to identify genotypes (aa, bb, ab) for ecNOS gene intron 4 VNTR polymorphism. All grafts were placed in brachioaxillary position. The subjects were divided into two groups based on duration of graft patency. The thrombosis group (Group I) comprised 26 patients who developed AVG thrombosis in the first 12 months after placement. The no-thrombosis group (Group II) comprised 29 patients whose grafts remained patient for at least 12 months. The frequency of the aa genotype in Group I was significantly higher than that in Group II (p =. 005). At 6, 12, and 24 months, the primary patency rates for the AVGs in patients with the aa genotype were significantly lower than the corresponding rates for the bb and ab genotype groupings (p =. 01, p =. 01 and p =. 04 for the three respective time points; Kaplan–Meier). ecNOS gene intron 4 VNTR polymorphism is linked with the pathogenesis of vascular access thrombosis in Turkish patients undergoing hemodialysis.
Journal of Surgical Research | 2011
Sedat Belli; O. Basaran; B. Handan Ozdemir; Suna Turkoglu; Gulten Karabay; Altug Kut; H. Karakayali; Mehmet Haberal
BACKGROUND Smoke inhalation injury is a major comorbid factor in patients with thermal injury and occurs in about 30% of patients with major burns. In addition, inhalation injury reportedly accounts for 20%-84% of the mortality in burned individuals and is associated with higher mortality rates for every age and burn size category. The aim of the present study was to investigate the effects of simvastatin on lung damage with burn and cotton smoke inhalation. METHODS Wistar rats were randomly assigned to three groups: saline treated control group, via an orogastric route (group 1, n = 6), burn (30%) and cotton smoke inhalated group (group 2, n = 6), and simvastatin treated (25 mg/kg/d, via an orogastric route) burn (30%) and cotton smoke inhalated group (group 3, n = 6). Rats were sacrificed at 48 h of the treatments and the trachea and lungs were removed completely. Tissue samples were taken for histopathologic, immunohistopathologic, and biochemical analyses. Univariate analysis of variance coupled with Duncans post-hoc test was performed for statistical evaluation. RESULTS Lung parenchymal and tracheoepithelial damage was confirmed in group 2 by histopathologic examination. Lung malonedialdehyde (MDA) levels were significantly decreased (P < 0.001), while glutathione (GSH) concentration did not alter in group 2 compared with group 1. Also, immunopathologic data revealed that epithelial iNOS level was elevated, while no modulation was detected in the level of myeloperoxidase (MPO). Simvastatin administration resulted in decreasing the lung parenchymal and tracheoepithelial damage. Tissue MDA levels were decreased significantly (P < 0.001), whereas GSH concentrations were elevated in group 3 compared with group 1 and group 2 (P < 0.001). Simvastatin treatment caused a decrease in epithelial iNOS levels, while MPO levels were not modulated. In addition, simvastatin significantly reduced pulmonary apoptosis in lung injury. CONCLUSIONS Our results have indicated that simvastatin administration seems to play beneficial role in lung injury of rats promoted by combined burn and smoke inhalation. Thus, simvastatin may represent a potential approach to prevent smoke inhalation-associated lung dysfunction. However, the significant decrease in basal oxidant production may cause impairment in cellular signalling processes.
Transplantation Proceedings | 2002
H. Karakayali; Gokhan Moray; Kenan Caliskan; O. Basaran; Mehmet Haberal
HE incidence of gastrointestinal (GI) complications in renal transplant recipients is relatively high compared with that of the normal population. Even a minor GI complication in immunosuppressed individuals may become severe, leading to graft loss or even patient death. Reports in the literature note an increased risk for a wide range of GI disorders during the post-transplantation period. 1 Although most of the problems may be managed with appropriate medical treatment, some require surgery. The aim of this study was to retrospectively analyze the GI complications that require surgery in immunosuppressed patients post-transplantation. MATERIALS AND METHODS
Burns | 2008
Funda Timurkaynak; Hande Arslan; Ö. Kurt Azap; S. Serin Senger; O. Basaran; S. Özbalikci Karaman; Mehmet Haberal
Infections in burn patients are usually caused by multidrug-resistant micro-organisms. Tigecycline, a derivative of glycylcyclines, is an effective antibiotic against the resistant strains. The aim of this study is to determine the in vitro activity of tigecycline against the multidrug-resistant bacteria isolated from burn patients. Fourty-seven bacteria isolated from 118 patients hospitalized in the burn unit during 2003-2006 were included in the study. Gram-negative bacteria that were resistant to at least six broad-spectrum antibiotics, methicillin-resistant staphylococci and ampicillin-resistant enterococci were studied. Minimal inhibitory concentration values of tigecycline against these bacteria were tested by E-test strips. Susceptibility breakpoints were determined according to the previous studies; <or=0.25mg/L for enterococci, <or=0.5mg/L for staphylococci and <or=2mg/L for Acinetobacter baumannii. Thirty-six percent of the materials were obtained from tissue specimens, 30% from wound, 25% from blood and 9% from other samples (e.g., catheter, tracheal aspiration, urine). MIC(90) values were 2, 0.25 and 1.5mg/L and susceptibility rates were 99.4%, 93.6%, 85.5% for A. baumannii, enterococci and MRSA, respectively. To conclude, this study demonstrated that tigecycline exhibits in vitro activity against clinical isolates of MDR A. baumannii, MRSA, and Enterococcus spp. isolated from burn patients. Tigecycline is a promising therapeutic option for difficult to treat burn infections due to these pathogens.
Journal of Investigative Surgery | 2004
Mahmut Can Yağmurdur; O. Basaran; Handan Ozdemir; Gürden Gür; M Turan; Hamdi Karakayal; Mehmet Haberal
Transient increased intra-abdominal pressure (IIAP) due to carbon dioxide insufflation is suspected to cause a form of ischemia–reperfusion injury. Considering this, a study was designed to assess the effect of transient IIAP on liver regeneration in a rat model. Six groups of animals (each n = 6) were studied. While experiments in Group 1 (IIAP + PHR) were subjected to IIAP, following partial hepatic resection (PHR), those in Group 2 (IIAP) experiments were subjected to IIAP. Animals in Group 3 (IR + PHR) were subjected to liver ischemia–reperfusion (IR) following PHR, and those in Group 4 (IR) underwent only IR. Group 5 (PHR) and Group 6 (healthy) served as controls. Blood was taken for assessment of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 with enzyme-linked immunosorbent assay (ELISA) at day 5 postoperatively. Each rat was then given a lethal injection of pentobarbital. Gravimetric analysis and immunohistochemistry staining for proliferating cell nuclear antigen (PCNA) were used for assessments of liver regeneration. Apoptosis was assessed by immunohistochemical TUNEL index, expressed as the number of positive cells/per total number of cells at the same time. Although mean liver regeneration rates of Group 1 and Group 3 were the same, that of Group 5 was the highest (p =. 04). Serum TNF-alpha levels of Group 1 versus Group 3 were 340 pg/ml versus 352 pg/ml. Serum IL-6 levels of Group 1 versus Group 3 were 124 pg/ml versus 135 pg/ml. Serum TNF-alpha and IL-6 levels of Group 1 and Group 3 were the same at the first day of surgical procedure (p >.05). Mean serum TNF-alpha levels of Group 5 (387 pg/ml) were significantly higher than those of both Group 1 and Group 3 at 24 h of operation. Serum IL-6 levels of Group 5 (174 pg/ml) at the same time was higher than those of Group 1 and Group 3 at the same time (p =. 01). Proliferating cell nuclear antigen indices of Group 1, Group 2, Group 3, Group 4, and Group 6 were the same; however, the mean PCNA-labeling index of Group 5 was higher than those of the others. There were no significant differences between the groups (p >.05). Liver regeneration is suppressed by transient IIAP. However, the effect of IIAP on liver apoptosis needs to be clarified.
Transplantation Proceedings | 2002
Mehmet Haberal; Gokhan Moray; H. Karakayali; R Emiroğlu; O. Basaran; S. Sevmis; Beyhan Demirhan
CANCER is more common in transplant recipients than in the general population. The reported incidence of malignant tumors after renal transplantation is 14 to 500 times higher than the rate in the general population. The prevalence of malignant tumors in different series of renal recipients ranges from 1 to 16% (mean 4%) and varies with type of organ transplant, age of the recipient, individual transplant center, and type of immunosuppression (IS). Other possible contributing factors are chronic antigenic stimulation, oncogenic virus activation, genetic susceptibility, and uremia. In this article, we describe 50 cases of malignant tumor development in renal transplant recipients who were treated with different immunosuppressive protocols in the Transplantation Center at Baskent University Faculty of Medicine.