O. Livi

The nitration of some methyl substituted indole-3-aldehydes

Abstract The reactions of some methyl derivatives of indole-3-aldehyde with nitric acid in acetic acid medium have been investigated. 2-Methylindole-3-aldehyde gives the 6-nitro derivative, together with some 2-methyl-3-nitro- and 2-methyl-3,6-dinitroindole. 1-Methylindole-3-aldehyde gives 4- and 6-nitro derivatives, 1-methyl-3-nitroindole, 1-methyl-5-nitroisatin, N-formyl-N-methyl-5-nitro-anthranilic acid and N-methyl-5-nitroanthranilic acid. 1,2-Dimethylindole-3-aldehyde gives 1,2-dimethyl-3-nitroindole, 1,2-dimethyl-3,6-dinitroindole, N-methyl-4-nitroanthranilic acid and 4- and 6-nitro-2-methylaminobenzonitrile.

Determination of constitution and synthesis of a new flavone fromcistus monspeliensis L.

Abstract A new flavone, isolated from Cistus monspeliensis , has been identified as myricetin-3,7,3′, 4′-tetramethyl ether [I], supported by UV, IR and NMR data and degradation experiments. The new compounds has also been prepared by an Allan-Robinson type synthesis.

N-Benzyl-4-Phenyl-1,2,3-triazole derivatives as in vitro inhibitors of the prostaglandin synthesis

Numerous N-benzyl-4-phenyl-1,2,3-triazole derivatives were synthesized and tested. The compounds were prepared by nucleophilic substitution, 1,3-dipolar cycloaddition and usual functional group conversion reactions. Several derivatives were evaluated in vitro for their ability to inhibit prostaglandin synthesis and to displace labelled [14C] indomethacin from bovine vesicular gland microsomes. Some compounds showed biological activity.