O. P. Cherkasova

Application of time-domain THz spectroscopy for studying blood plasma of rats with experimental diabetes

The absorption spectra of rat blood plasma have been studied by time-domain THz spectroscopy in the frequency range from 0.1 to 2.0 THz. The absorption coefficient of blood plasma is found to be significantly reduced, depending on the diabetes severity.

Analysis of blood plasma at terahertz frequencies

Terahertz time-domain spectroscopy in the 0.05-2.5 THz frequency range was employed to analyze blood plasma samples obtained from laboratory animals with experimental diabetes and from healthy controls. It was found that transmission and reflection coefficients of samples from rats with diabetes differed significantly from control values in both amplitude and phase. The cause of the detected differences is discussed with respect to variation in the terahertz response of water.

Study of the dielectric function of aqueous solutions of glucose and albumin by THz time-domain spectroscopy

We report a study of aqueous solutions of glucose and bovine serum albumin using THz time-domain spectroscopy. To describe the permittivity of the solutions of these substances, we use a simplified model being applicable in the frequency range of 0.05 – 2.7 THz. On the assumption that most of the water molecules become bound at high concentrations of glucose and protein in the solution, the changes in water characteristics are investigated. To improve the reliability of the results, the measurements are performed by two independent methods: the method of attenuated total internal reflection and the transmission method. Combination of the results obtained by these two methods allows expanding the spectral range towards lower frequencies.

Studying human and animal skin optical properties by terahertz time-domain spectroscopy

Human and rat skin reflection spectra and the effect of glucose and glycerol on these spectra are studied in vivo by terahertz time-domain spectroscopy in the frequency range of 0.1–2.0 THz. Variations in skin optical properties proved to correlate with changes in the blood glucose level.

Application of terahertz time-domain spectroscopy for blood glucose monitoring

Human skin optical properties were studied in vivo using terahertz time-domain spectroscopy. For the attenuated total internal reflection, the silicon Dowe prism was used. The measurements were carried out on volunteers with normal blood glucose concentration and after glucose intake. The variations of the reflection spectra of human skin were correlated with the changes in blood glucose level.

Investigation of bovine serum albumin glycation by THz spectroscopy

Protein glycation is accelerated under hyperglycemic conditions resulting to loss in the structure and biological functions of proteins. The transmission THz spectroscopy has been used for measuring of bovine serum albumin glycation dynamics. It was found that amplitude of albumin THz absorption depends on type of sugars and incubation time.

Investigation of spectral features of progesterone, 17a-hydroxyprogesterone and cortisone in THz range

The THz and Raman spectra of progesterone, 17a-hydroxyprogesterone and cortisone in the region of low-frequency infrared vibrations have been measured. Several intensive bands have unusual temperature dependence. Vibration frequencies are calculated by density functional theory.