O. S. Kukovinets

Ozonolysis of Unsaturated Carbonyl Compounds and Alcohols

Mechanisms of ozonolysis of unsaturated carbonyl compounds and alcohols were considered, and the effects of the substrate structure and reaction conditions on the product composition were analyzed.

Insect pheromones and their analogs LIX. A new method for the synthesis of components of the sex pheromones of insects of the genusMalacosoma

A new method has been developed for the synthesis of the main components of the sex pheromones of insects of theMalacasoma genus that is based on the selective transformation of the product of the partial ozonolysis of cyclohexa-1,4-diene — methyl 6-oxohex-4E-enoate.

Regioselective oxidation of the methyl ester of maleopimaric acid by dimethyldioxirane

Reaction of the methyl ester of maleopimaric acid and dimethyldioxirane resulted in regioselective oxidation of the bridging double bond to form the 13(15)-en-14S-hydroxy derivative.

Oxidative transformations of polyprenols

Oxidative transformationsinvolving the hydroxylsand ω-methylsof polyprenolsisolated from birch greenery (7-9 isoprene units in the chain) were used to produce α,ω-diols, diesters, aldehydoalcohols, and hydroxyacids. The products are of interest as potential anti-inflammatory, antiulcer, hepatoprotective, and cardio-active preparations.

Reaction of apple pectin modified by pharmacophores, with copper(II) cations

The reaction of apple pectin modified by organic pharmacophores (nicotinic, salicylic, 5-aminosalicylic, and anthranilic acids) with Cu(II) cations was studied by spectral methods. The compositions of the complexes were determined and their stability constants, as well as the thermodynamic parameters (ΔH0, ΔG0, ΔS0) of the complex formation were calculated. The structure of the drug in the polymeric ligand was found to affect certain physicochemical properties of the metal complexes.

Ozonation of Quinopimaric Acid Methyl Ester and Its 2,3-Dihydro Derivatives with Sterically Hindered Double Bonds

Ozonation of quinopimaric acid methyl ester and its 2,3-dihydro derivatives involves 1,2-addition of ozone to the sterically hindered double bonds with formation of peroxy epoxides and intramolecular interaction products.

Modification of hyaluronic acid and chitosan, aimed at developing hydrogels for ophthalmology

Modification of hyaluronic acid and chitosan with the aim of preparing hydrogels based on them was performed. The formation of a covalent bond between mitomycin C and hyaluronic acid modified with epichlorohydrin was demonstrated. Hydrogels based on hyaluronic acid dialdehyde and chitosan modified with succinic anhydride were prepared. The degree of modification and concentration of the polymers influence the gelation process. Prolonged release of mitomycin C from the hydrogel obtained was revealed.

Complexation of Apple Pectin with Several Nitrogenand Oxygen-Containing Organic Pharmacophores

The interaction of native and de-esterified apple pectin with nicotinic acid, methyluracil, 5-aminosalicylic acid, ascorbic acid, and tryptophan was studied by spectral methods. The composition was established. Stability constants were calculated. The molecular and hydrodynamic characteristics of the obtained complexes and several of their surface properties were determined.

Epoxidation of syndiotactic 1,2-polybutadiene with peracids

The epoxidation of syndiotactic 1,2-polybutadiene (84 and 16% 1,2 and 1,4 units, respectively) with carboxylic peracids prepared in situ and m-chloroperbenzoic acid was studied. In the course of epoxidation in the presence of carboxylic peracids, oxirane groups are formed only through epoxidation of double bonds in the macromolecular backbone, whereas m-chloroperbenzoic acid is responsible for the chemical modification of 1,2 and 1,4 units of polybutadiene. The basic kinetic parameters of 1,2-polybutadiene epoxidation with peracids of various chemical structures were determined.

Synthesis of aryl-containing isoprenoids from 1,5-dimethylcycloocta-1,5-diene

A procedure has been developed for the synthesis of Pro-Drone homo analogs from the ozonolysis products of 1,5-dimethylcycloocta-1,5-diene and 1,5-dimethylcyclooctene.