O. Yalcin Cok

Abstract PR342: Gender Based Sedation Reduces Procedural Pain, Decreases Anxiety And Improves Satisfaction During Lasik Surgery with Femtosecond Laser

Background & Objectives: Laser in situ keratomileusis using femtosecond Laser (LASIK-FsL), an ophthalmic procedure, is performed for correction of refractive errors in which the flap is fashioned by femtosecond laser not by a mechanical microkeratome. The procedure is mostly performed under topical anesthesia with or without sedation. Sedation is used to avoid pain and anxiety which can be influenced by gender and age. Due to mostly standardized and precise structure of LASIK-FsL operations, we investigated the effects of sedation, gender and age on procedural pain, anxiety and satisfaction during LASIK-FsL.

634 COMPARISON OF INTERSCALENE BLOCK WITH 0.25% BUPIVACAINE AND 0.25% LEVOBUPIVACAINE FOR SHOULDER SURGERY: A RANDOMIZED, DOUBLE‐BLIND STUDY

Results: 35 patients were included with mean age of 70.2 years. The time between admission and surgery was mean 26 hours, 9 patients has more than one episode of nausea-vomiting, 3 patients developed postoperative delirium (9%) and all patients had postoperative VAS pain score less then 5. The supplemental analgesia was mean 20.5 hours. Conclusion: Our study shows that intratecal injection of 0.1mg Morphine in elderly patients with hip fracture is associated with a good quality of analgesia and low incidence of postoperative delirium.

553 THE EVALUATION OF PERIPHERAL NERVE BLOCKS WITH STEROIDS IN THE MANAGEMENT OF ACUTE AND CHRONIC NEUROPATHIC PAIN DUE TO TRAUMA

Methods: In a pan-European study, the per protocol set comprised 88 patients with PHN and 193 patients with painful DPN, randomized to lidocaine plaster or oral pregabalin (titrated to effect: 300 or 600mg/day). Primary efficacy endpoint was a ≥ 2 point reduction from baseline in NRS-3 or an overall score of ≤ 4 after 4 weeks’ treatment. Results: For PHN, higher response rates were observed for lidocaine plaster (61.2%;28/45) than for pregabalin (46.5%;20/43). For DPN, response rates were comparable for both treatment groups (lidocaine plaster: 66.7%;66/99; pregabalin: 69.1%;65/94). As expected, painful allodynia was more frequent with PHN compared to DPN at Baseline. Improvement in patients with PHN was statistically significant for lidocaine plaster, but not for pregabalin. Patients with DPN showed comparable improvement for both treatments. Significantly fewer patients in the lidocaine plaster group experienced drug-related adverse events: 5.8% (9/155) versus 41.2% (63/153; p < 0.0001). Overall, 36 pregabalin patients experienced drug-related adverse events leading to discontinuation, compared with 4 for lidocaine plaster. Conclusions: 5% lidocaine medicated plaster showed higher efficacy than pregabalin in patients with PHN. For DPN, efficacy was comparable for both treatments. 5% lidocaine medicated plaster showed a favourable efficacy/safety profile compared to pregabalin in patients with PHN or painful DPN supporting its first line position in the treatment of focal neuropathic pain. Funded by Grünenthal