Obi Ekwenna
University of Miami
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Publication
Featured researches published by Obi Ekwenna.
Cancer | 2011
Mario W. Kramer; Diogo O. Escudero; Soum D. Lokeshwar; Roozbeh Golshani; Obi Ekwenna; Kristell Acosta; Axel S. Merseburger; Mark S. Soloway; Vinata B. Lokeshwar
Cancer biomarkers are the backbone for the implementation of individualized approaches to bladder cancer (BCa). Hyaluronic acid (HA) and all 7 members of the HA family, that is, HA synthases (HA1, HA2, HA3), HYAL‐1 hyaluronidase, and HA receptors (CD44s, CD44v, and RHAMM), function in tumor growth and progression. However, the diagnostic and prognostic potential of these 7 HA family members has not been compared simultaneously in any cancer. We evaluated the diagnostic and prognostic potential of HA family members in BCa.
BJUI | 2012
Scott M. Castle; Vladislav Gorbatiy; Obi Ekwenna; Ezekiel E. Young; Raymond J. Leveillee
Study Type – Therapy (case series)
Cancer | 2013
Travis Yates; Judith Knapp; Miguel Gosalbez; Soum D. Lokeshwar; Christopher Gomez; Anaid Benitez; Obi Ekwenna; Ezekiel E. Young; Murugesan Manoharan; Vinata B. Lokeshwar
C‐X‐C chemokine receptor 4 (CXCR4) and CXCR7 are 7‐transmembrane chemokine receptors of the stroma‐derived factor (SDF‐1). CXCR4, but not CXCR7, has been examined in bladder cancer (BCa). This study examined the functional and clinical significance of CXCR7 in BCa.
Cancer | 2012
Andrew Chi; Samir P. Shirodkar; Diogo O. Escudero; Obi Ekwenna; Travis Yates; Rajinikanth Ayyathurai; Michael Garcia-Roig; Jeffrey Gahan; Murugesan Manoharan; Vincent G. Bird; Vinata B. Lokeshwar
Molecular profiling of renal cell carcinomas (RCCs) may improve the distinction between oncocytoma and malignant RCC subtypes and aid in early detection of metastasis. The hyaluronic acid (HA) family includes HA synthases (HAS1, HAS2, HAS3), hyaluronidases (HYAL‐1, HYAL‐2, HYAL‐3, HYAL‐4, PH20, HYAL‐P1), and HA receptors (CD44s, CD44v, RHAMM). HA family members promote tumor growth and metastasis. The authors evaluated the expression of HA family members in kidney specimens.
Prostate Cancer and Prostatic Diseases | 2012
Michael A. Gorin; Ahmed Eldefrawy; Obi Ekwenna; Mark S. Soloway
Background:This study aimed to survey urologists regarding their knowledge, acceptance and practice of active surveillance (AS) for low-risk prostate cancer.Methods:An email-based survey was distributed to 4987 urologists. Respondents were surveyed regarding their knowledge and acceptance of AS. Those who felt AS was a reasonable strategy were asked their opinions on the criteria for AS enrollment and the details of their practice of AS. Respondents who felt AS was not a reasonable alternative were queried as to the reasons why.Results:A total of 425 (9%) urologists successfully completed the survey and 387 (91%) were both familiar with AS and aware that AS differed from watchful waiting. Of this latter group, 370 (96%) respondents felt AS was a reasonable management strategy, 95% of whom manage patients with this approach. A minority of respondents (6%) felt that patients with a PSA>10 ng ml−1 were eligible for AS. Further, most participants (74%) felt that patients required a Gleason score ⩽6. There was little agreement on the timing of follow-up biopsies. Respondents who objected to AS were most commonly concerned with missing an opportunity for curative treatment (76%) and the risk of tumor undergrading (65%).Conclusions:The majority of participants were knowledgeable and accepting of AS. Respondents were in relative agreement regarding the PSA and Gleason score criteria for AS enrollment. In contrast, there was a lack of agreement on the timing of follow-up biopsies. In the future, comparative studies are required to determine the optimal enrollment criteria and follow-up protocol for patients managed with AS.
Current Urology Reports | 2011
Scott M. Castle; Vladislav Gorbatiy; Obi Ekwenna; Raymond J. Leveillee
Multiple modalities exist for the management of small renal tumors, including active surveillance, extirpation (radical nephrectomy and partial nephrectomy), and ablative therapies. Radiofrequency ablation (RFA) is an alternative to extirpative surgery for renal tumors. This article presents the current literature on RFA for renal tumors. We reviewed 28 RFA series in the English literature from 2003 to 2010 to assess patient selection, biopsy, renal outcomes, and oncologic outcomes.
Urology | 2012
Michael A. Gorin; Obi Ekwenna; Mark S. Soloway; Gaetano Ciancio
Neoadjuvant sunitinib has recently been described for the management of renal cell carcinoma. We present the pre and posttreatment images of a 49-year-old male with bilateral biopsy-proven clear cell renal cell carcinoma who underwent treatment with sunitinib prior to nephron-sparing surgery. After four four-week cycles of daily 50 mg sunitinib, the patient demonstrated a dramatic reduction in tumor burden allowing for successful bilateral partial nephrectomy.
The Scientific World Journal | 2011
Obi Ekwenna; Michael A. Gorin; Miguel Castellan; Victor J. Casillas; Gaetano Ciancio
Nutcracker syndrome is described as the symptomatic compression of left renal vein between the aorta and the superior mesenteric artery, resulting in outflow congestion of the left kidney. We present the case of a 51-year-old male with a left-sided inferior vena cava, resulting in compression of the right renal vein by the superior mesenteric artery. Secondary to this anatomic anomaly, the patient experienced a many-year history of flank pain and intermittent gross hematuria. We have termed this unusual anatomic finding and its associated symptoms as the “inverted nutcracker syndrome”, and describe its successful management with nephrectomy and autotransplantation.
Urology Annals | 2013
Prashanth Kanagarajah; Obi Ekwenna; Rajinikanth Ayyathurai; George W Burk; Gaetano Ciancio
We present a case in which a deceased donor kidney with a large simple cyst was successfully unroofed and transplanted to a 61-year-old male. The donor was a 62-year-old male with a history of hypertension for 2 years; cerebral vascular accident was the cause of death. A large 8-cm cyst distorting the renal hilum was identified upon the procurement of the deceased donor kidney. Prior to transplantation, the large cyst was unroofed from the allograft; the frozen section confirmed a benign cyst and the transplant was performed. Postoperatively, the serum creatinine level was 1.4 mg/ml at 22-month follow-up and the patient was normotensive. Deceased donor kidneys with giant cysts distorting the renal hilum can be effectively transplanted.
Cancer | 2012
Travis Yates; Judith Knapp; Miguel Gosalbez; Soum D. Lokeshwar; Christopher Gomez; Anaid Benitez; Obi Ekwenna; Ezekiel E. Young; Murugesan Manoharan; Vinata B. Lokeshwar
C‐X‐C chemokine receptor 4 (CXCR4) and CXCR7 are 7‐transmembrane chemokine receptors of the stroma‐derived factor (SDF‐1). CXCR4, but not CXCR7, has been examined in bladder cancer (BCa). This study examined the functional and clinical significance of CXCR7 in BCa.