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Dive into the research topics where Oded Ayzenberg is active.

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Featured researches published by Oded Ayzenberg.


Journal of The American Society of Echocardiography | 2011

Differential Effects of Coronary Artery Stenosis on Myocardial Function: The Value of Myocardial Strain Analysis for the Detection of Coronary Artery Disease

Sara Shimoni; Gera Gendelman; Oded Ayzenberg; Nahum Smirin; Peter Lysyansky; Orly Edri; Lisa Deutsch; Avraham Caspi; Zvi Friedman

BACKGROUND Speckle-tracking imaging is a novel method for assessing left ventricular (LV) function and ischemic changes. The aim of this study was to assess the predictive value of two-dimensional longitudinal strain in the detection of longitudinal LV dysfunction and the identification of coronary artery disease (CAD) in patients hospitalized with angina. METHODS Two-dimensional strain software was extended to allow the analysis of numerous longitudinal strain traces in the entire left ventricle and generate a histogram of peak systolic strain (PSS) values for the left ventricle and for each coronary territory. In each histogram, the value of the 10% worst strain values (PSS(10%)) was determined. Global strain, segmental PSS, and PSS(10%) were analyzed in 97 patients hospitalized with angina and had normal LV function, who underwent coronary angiography, and 51 patients with low probability of CAD. Echocardiography was performed 2.9 ± 2 days after admission. RESULTS Sixty-nine patients had significant CAD on coronary angiography. Significant differences were observed in all strain parameters between patients with and without CAD. PSS(10%) showed the best accuracy in detecting CAD, with an area under the receiver operating characteristic curve of 0.85. The areas under the curve for global strain and segmental PSS were 0.80 and 0.76, respectively. The optimal cutoff for PSS(10%) was -13.9%, with sensitivity and specificity of 86% and 75%, respectively. PSS(10%) was better than segmental PSS in the detection of CAD in each coronary territory. CONCLUSIONS In patients hospitalized with angina who have significant CAD on coronary angiography, longitudinal systolic function is impaired. Histogram analysis improved the accuracy of longitudinal strain analysis in detecting global and regional impaired function.


Catheterization and Cardiovascular Interventions | 2003

Preliminary experiences using X-sizer catheter for mechanical thrombectomy of thrombus-containing lesions during acute coronary syndromes.

Ran Kornowski; Oded Ayzenberg; David A. Halon; Fabio Kusniec; Abid Assali

Thrombus‐containing lesions are frequently observed in patients with acute coronary syndromes. These lesions are prone to increased procedural risks, including distal embolization and abrupt closure of the vessel. This preliminary report evaluates if thrombus removal using a new X‐Sizer catheter could reduce thrombotic burden and optimize angioplasty results. Thrombectomy was attempted with the X‐Sizer catheter in 11 patients (age, 59 ± 10 years) undergoing coronary angioplasty with angiographic evidence of intracoronary thrombus. The device uses a helix cutter contained in a 4.5 or 5.5 Fr catheter tip connected to a closed vacuum aspiration system. Procedural outcomes using detailed angiographic analysis and clinical data were obtained from all treated patients. Seven patients (64%) had acute or recent myocardial infarction and four patients (36%) presented with unstable angina. The culprit lesion was located in right coronary, left anterior, vein graft, and circumflex‐marginal in five, three, two, and one patient, respectively. The mean proximal reference diameter was 3.37 ± 0.39 mm and % diameter stenosis was 90% ± 15% prior to thrombectomy and decreased to 72% ± 16% afterward and was 9% ± 10% at the end of the procedure. The TIMI flow increased from 0.8 ± 1.0 to 2.1 ± 0.9 following thrombectomy and the final TIMI grade was 2.9 ± 0.3. Stents were used in 9 of 11 patients. Procedural success was achieved in 10 of 11 patients (91%). No evidence of stent thrombosis was noted among treated patients in hospital and at 30‐day follow‐up. In this preliminary series of patients with angiographic evidence of thrombus, the use of X‐Sizer thrombectomy seems to be feasible and relatively safe, permitting thrombus removal and improved intracoronary flow. Cathet Cardiovasc Intervent 2003;58:443–448.


World Journal of Cardiology | 2012

Anti-oxidized low-density lipoprotein antibodies in chronic heart failure.

Gideon Charach; Alexander Rabinovich; Ori Argov; Moshe Weintraub; Lior Charach; Oded Ayzenberg; Jacob George

Oxidative stress may play a significant role in the pathogenesis of heart failure (HF). Antibodies to oxidized low-density lipoprotein (oxLDL Abs) reflect an immune response to LDL over a prolonged period and may represent long-term oxidative stress in HF. The oxLDL plasma level is a useful predictor of mortality in HF patients, and measurement of the oxLDL Abs level may allow better management of those patients. Antibodies to oxLDL also significantly correlate with the New York Heart Association score. Hypercholesterolemia, smoking, hypertension, and obesity are risk factors for atherosclerotic coronary heart disease (CHD) leading to HF, but these factors account for only one-half of all cases, and understanding of the pathologic process underlying HF remains incomplete. Nutrients with antioxidant properties can reduce the susceptibility of LDL to oxidation. Antioxidant therapy may be an adjunct to lipid-lowering, angiotensin converting enzyme inhibition and metformin (in diabetes) therapy for the greatest impact on CHD and HF. Observational data suggest a protective effect of antioxidant supplementation on the incidence of HD. This review summarizes the data on oxLDL Abs as a predictor of morbidity and mortality in HF patients.


Atherosclerosis | 2011

Thoracic aortic atherosclerosis in patients with aortic regurgitation

Sara Shimoni; Liaz Zilberman; Orly Edri; Iris Bar; Sorel Goland; Gera Gendelman; Moshe Swissa; Shay Livshitz; Ofir Paz; Oded Ayzenberg; Jacob George

OBJECTIVE Hemodynamic forces are potential determinants of aortic atherosclerosis. Aortic regurgitation (AR) alters the flow pattern in the aorta. However, the association between AR and aortic atherosclerosis is not well known. METHODS We assessed the presence, extent and distribution of atherosclerotic lesions in the aorta of 42 patients with chronic AR and compared them to 40 patients with similar risk factor profile for atherosclerosis and no valvular disease. RESULTS There was no difference in the extent of atheroma in the ascending aorta and aortic arch between patients with and without AR. Descending aortic atheroma was evident in 25 patients with AR (60%) and 12 patients without AR (30%, p=0.01). AR was found to be the only predicting factor for the presence of aortic atherosclerosis in the descending aorta (odds ratio 4.1; 95% CI 1.2-14.3, p=0.03). CONCLUSIONS There is an increased prevalence of descending aortic atherosclerosis in patients with significant AR.


Cardiovascular Revascularization Medicine | 2014

Prospective, multi-center evaluation of a silicon carbide coated cobalt chromium bare metal stent for percutaneous coronary interventions: Two-year results of the ENERGY Registry

Raimund Erbel; Holger Eggebrecht; Ariel Roguin; Erwin Schroeder; Sebastian Philipp; Thomas Heitzer; Harald Schwacke; Oded Ayzenberg; Antonio Serra; Nicolas Delarche; Andreas Luchner; Ton Slagboom

BACKGROUND Novel bare metal stents with improved stent design may become a viable alternative to drug-eluting stents in certain patient groups, particularly, when long-term dual antiplatelet therapy should be avoided. PURPOSE The ENERGY registry aimed to assess the safety and benefits of a cobalt-chromium thin strut bare metal stent with a passive coating in a large series of patients under real-world conditions. METHODS AND MATERIALS This prospective registry recruited 1016 patients with 1074 lesions in 48 centers from April to November 2010. The primary endpoint was the rate of major adverse cardiac events (MACEs), a composite of cardiac death, myocardial infarction and clinically driven target lesion revascularization. RESULTS More than half of the lesions (61.0%) were type A/B1 lesions, mean lesion length was 14.5±6.5mm and mean reference vessel diameter 3.2±0.5mm. MACE rates at 6, 12 and 24months were 4.9%, 8.1% and 9.4%, target lesion revascularization rates 2.8%, 4.9% and 5.4% and definite stent thrombosis rates 0.5%, 0.6% and 0.6%. Subgroups showed significant differences in baseline and procedural characteristics which did not translate into significantly different clinical outcomes. Specifically, MACE rates at 24months were 13.5% in diabetics, 8.6% in small stents and 9.6% in acute coronary syndrome patients. CONCLUSION The population of ENERGY reflects real-world conditions with bare metal stents being mainly used in simple lesions. In this setting, percutaneous coronary intervention using a cobalt-chromium thin strut bare metal stent with a passive coating showed very good results up to 24months. (ClinicalTrials.gov:NCT01056120) SUMMARY FOR ANNOTATED TABLE OF CONTENTS: The ENERGY international registry evaluated the safety and benefits of a cobalt-chromium thin strut bare metal stent with passive coating in 1016 patients under real-world conditions until 2years. Results were encouraging with a low composite rate of cardiac death, myocardial infarction and clinically driven target lesion revascularization, even in the pre-defined high risk groups of diabetes, stents ≤2.75mm and acute coronary syndrome.


Metabolism-clinical and Experimental | 2009

High–molecular weight adiponectin is associated with coronary artery angiographic findings in Asian Indians

Taiba Zornitzki; Naama Reshef; Oded Ayzenberg; Rinat Cohen; Gera Gandelman; Jan Frystyk; Allan Flyvbjerg; Hilla Knobler

Asian Indians (AIs) have a higher prevalence and a more aggressive form of coronary artery disease (CAD), and it has been suggested that hypoadiponectinemia may have a role in this accelerated CAD. The present study was undertaken to determine the extent and severity of angiographic findings in 2 groups of CAD patients matched for age and sex, AIs (n = 29) vs whites (n = 30), and to elucidate the potential relationship between adiponectin (total and high-molecular weight [HMW] form) and the severity and extent of coronary angiographic findings in both groups. Angiographic findings were assessed using the modified Gensini index; and 2 scores, scores 1 and 2, were used to assess the severity and extent. Both Gensini index scores 1 and 2 were higher in the AI group compared with the white group (144.4 +/- 87.1 vs 93.5 +/- 56.3 and 127.2 +/- 86.5 vs 80.1 +/- 39.3, respectively; P < .05). Adiponectin levels were similar in both groups. Total adiponectin and HMW adiponectin were positively associated with Gensini index score 1 (r = 0.62, P = .004 and r = 0.64, P = .003) and score 2 (r = 0.51, P = .021 and r = 0.54, P = .013), respectively, in AI men, whereas there was no significant association in white men. Thus, AIs had more severe CAD compared with whites; and in AI men with CAD, total adiponectin and HMW adiponectin were associated with the severity of angiographic scores.


Cardiovascular Drugs and Therapy | 2003

A high incidence of vitamin B12 deficiency in israeli patients undergoing coronary angiography

Sorel Goland; Oded Ayzenberg; Fabio Kuznitz; Sara Shimoni; Avraham Caspi; Stephen Malnick

Sir, Treatment with a mixture of vitamin B12, vitamin B6 and folic acid has been shown to decrease the rate of restenosis after coronary angioplasty [1,2]. This is thought to be related to a decrease in the level of serum homocysteine [3]. This is loosely referred to as folate supplementation. The administration of folic acid alone in the presence of vitamin B12 deficiency may have consequences of neurological damage [4]. We decided to determine the prevalence of vitamin B12 deficiency in our population, in order to see whether a policy of pure folic acid administration would be feasible. One hundred thirty serial patients presenting for coronary angiography in the Heart Institute of Kaplan Medical Center were included in this study. A note was made of the number of vessels involved, presence of hypertension, smoking or hyperlipidemia (LDL cholesterol >130 mg/dL), CBC and MCV, vitamin B12, folic acid and whether angioplasty was performed or not. Significant coronary disease was defined as a greater than 50% diameter stenosis on multiple views. Vitamin B12 (cobalamin) was determined by the Access-Sanofi Pasteur System, France chemiluminescence assay and folic acid was also determined by chemiluminescence. We have chosen a level of 200 pg/ml as the lower limit of normal for vitamin B12 since this has been reported to have a specificity of 95–100% [5]. The mean vitamin B12 level of these patients was 308.34 ± 181.88 pg/mL. There were 39 patients (29.55%) with a level of vitamin B12 less than 200 pg/mL. The average vitamin B12 level of these patients was 145.1 ± 30.89 pg/mL and the folic acid level of these patients was 11.58 ± 7.26 pg/mL. There were 91 patients with a serum B12 level above 200 pg/mL. The average vitamin B12 level was 345.37 ± 151.46 pg/mL and the folic acid level of these patients was 14.41 ± 7.11 pg/mL. There was no difference between the groups with a B12 <200 pg/mL and >200 pg/mL in terms of number of coronary vessels involved, need for angioplasty, unstable angina, myocardial infarction or hypertension (t-test, χ2 test and Mann-Whitney test). This finding of a high prevalence of vitamin B12 deficiency in Israel has been found previously [6,7] but not in a population of coronary artery disease patients. This requires further evaluation but we suggest that folate supplementation should either include vitamin B12 or that a separate determination of vitamin B12 be performed. Since vitamin B12 deficiency can have deleterious effects, this latter approach is to be preferred.


Journal of The American Society of Echocardiography | 1994

Echocardiographic Evaluation of the Five-Chamber Heart: A Rare Congenital Coronary Anomaly

Ruth Jortner; Werner G. Daniel; Oded Ayzenberg; Aref Saad; Paul A. Tunick; Itzhak Kronzon

Coronary artery fistulas are rare congenital anomalies that usually drain into one of the cardiac chambers or veins. The current patient was found to have a distinctly unusual anatomic picture, with a fifth cardiac chamber appearing at the cardiac apex. This proved to be the drainage site for a large coronary artery fistula originating in the left anterior descending coronary artery. The anatomic relations and blood flow patterns were demonstrated with transthoracic and transesophageal echocardiography.


Journal of the American College of Cardiology | 2013

TCT-183 ENERGY 1,000 Patient Registry with a Thin Strut Bare Metal Stent with Passive Coating presenting Two Year Data

Ariel Roguin; Ton Slagboom; Erwin Schroeder; Sebastian Philipp; Thomas Heitzer; Harald Schwacke; Oded Ayzenberg; Antonio Serra; Nicolas Delarche; Raimund Erbel

The PRO-Kinetic Energy is a thin strut (60μm) cobalt chromium alloy bare metal stent, which is coated with a thin layer of amorphous silicon carbide. The aim of this registry is to evaluate its clinical performance in a large patient population in standard clinical care. 1,016 consecutive patients


QJM: An International Journal of Medicine | 2007

Diabetes, but not the metabolic syndrome, predicts the severity and extent of coronary artery disease in women.

Taiba Zornitzki; Oded Ayzenberg; G. Gandelman; S. Vered; E. Yaskil; D. Faraggi; Abraham Caspi; Sorel Goland; O. Shvez; Ami Schattner; Hilla Knobler

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Alexander Rabinovich

Tel Aviv Sourasky Medical Center

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Ariel Roguin

Technion – Israel Institute of Technology

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Gideon Charach

Tel Aviv Sourasky Medical Center

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Lior Charach

Tel Aviv Sourasky Medical Center

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Orly Edri

Kaplan Medical Center

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