Okolicány J

The Anterior Third Ventricle Region is a Receptor Site for Composition Rather than Volume of Body Fluids

The first International Symposium on natriuretic hormones took place in 1969 at Smolenice Castle. At that time, the prevailing evidence pointed to the existence of only one specific natriuretic hormone: a small peptide. This hormone was postulated to inhibit the activity of the transporting enzyme, Na,K-ATPase, and was later classified as an endogenous inhibitor of the sodium pump—a digoxin-like substance. At a subsequent meeting in 1980 in Bratislava, it was decided to change the title to natriuretic hormones. The reason for the change was that in addition to the suggested, but still unidentified, natriuretic, hormone a number of well known hormones had been described that promoted renal sodium excretion (certain prostaglandins, kinins, dopamine, vasopressin, oxytocin, substance P, etc.) (1).