Oktay Taşkapan

Evaluation of patients with symptomatic dermographism

Background  Dermographism or ‘simple’ dermographism, which has been noted in about 1.5% to 5% of healthy individuals, is regarded as a normal physiological phenomenon. However, in symptomatic dermographism (SD), even light pressure or rubbing from clothes may provoke widespread weal‐and‐flare reactions with itching and burning. It is one of the dermatologic diseases that negatively impacts quality of life.

Acquired unilateral nevoid telangiectasia syndrome.

We describe a man with acquired unilateral nevoid telangiectasia syndrome, in whom no underlying disease, alcohol abuse or physiological conditions causing hormonal changes are demonstrable. To our knowledge, this is the first case of acquired unilateral nevoid telangiectasia syndrome seen in a healthy adult male and not associated with a hyperestrogenaemic state and estrogen receptor abnormality. This case report casts doubt on the commonly held view that unilateral nevoid telangiectasia syndrome is an estrogen-sensitive nevoid anomaly.

Atopy patch test reactivity to house dust mites in patients with scabies

It is well known that the house dust and the scabies mitesare related phylogenetically. We therefore performedatopy patch tests with house dust mite antigens (Dermato-phagoides pteronyssinus (Dp) and/or Dermatophagoidesfarinae (Df)) in scabies patients without atopy and healthycontrols. We studied 25 men with active scabies and 25healthy controls. Skin prick tests with standardized housedust mite extract were performed for all patients andcontrols. An intradermal test procedure was carried out inskin prick test-negative patients, and for controls showingpositive atopy patch test to Dp and/or Df. While atopypatch tests were performed directly in all healthy controls,patients with scabies were first treated and on the nextday, atopy patch tests were performed. Twenty-two of 25patients with scabies (88%) had skin prick test and/orintradermal test positivity against house dust mites,whereas 17/25 patients (68%) had atopy patch testpositivity against house dust mites (Dp and/or Df).There was no statistically significant difference betweenskin prick test and/or intradermal test positivity and atopypatch test positivity in a regression analysis (p50.222).The only statistically significant correlation was betweenatopy patch test positivity and the extent of scabiesinvolvement (pv0.05). Only few of the healthy controlshad positive tests. In this study, we have shown that apositive atopy patch test to house dust mite antigens is notspecific for patients with atopic dermatitis, but also occursin scabies patients without a history of atopic dermatitis.

A case of coumarin necrosis with penile and pedal involvement

A 57‐year‐old male patient with advanced adenocarcinoma of the lung, who was administered oral anticoagulant therapy because of pulmonary embolism, developed coumarin necrosis confined to the penis and feet. To our knowledge, this patient showing acral involvement is the seventh case of coumarin‐induced penile necrosis reported to date.

ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA: ATYPICAL APPEAREANCE IN AN OLDER PATIENT

We describe a 76-year-old man presenting with a chronic, non-healing ulcer of six-year duration on his left zygomatic area. The skin biopsy specimen taken from the lesion, showed increased vascular proliferation, edematous endothelial cells in the dermal blood vessels and perivascular eosinophilic/lymphocytic infiltration. The routine and specific blood tests were unremarkable. On the basis of these features, the patient was diagnosed as having angiolymphoid hyperplasia with eosinophilia (ALHE). We present the case because of its rarity in older people, atypical clinical appearance; and stress the consideration of ALHE in the differential diagnosis of chronic non-healing superficial ulcers confined to face and neck.

Atopy patch test reactions to house dust mites in patients with scabies.

It is well known that the house dust and the scabies mites are related phylogenetically. We therefore performed atopy patch tests with house dust mite antigens (Dermatophagoides pteronyssinus (Dp) and/or Dermatophagoides farinae (Df)) in scabies patients without atopy and healthy controls. We studied 25 men with active scabies and 25 healthy controls. Skin prick tests with standardized house dust mite extract were performed for all patients and controls. An intradermal test procedure was carried out in skin prick test-negative patients, and for controls showing positive atopy patch test to Dp and/or Df. While atopy patch tests were performed directly in all healthy controls, patients with scabies were first treated and on the next day, atopy patch tests were performed. Twenty-two of 25 patients with scabies (88%) had skin prick test and/or intradermal test positivity against house dust mites, whereas 17/25 patients (68%) had atopy patch test positivity against house dust mites (Dp and/or Df). There was no statistically significant difference between skin prick test and/or intradermal test positivity and atopy patch test positivity in a regression analysis (p=0.222). The only statistically significant correlation was between atopy patch test positivity and the extent of scabies involvement (p<0.05). Only few of the healthy controls had positive tests. In this study, we have shown that a positive atopy patch test to house dust mite antigens is not specific for patients with atopic dermatitis, but also occurs in scabies patients without a history of atopic dermatitis.

Local aggravation of erythema multiforme following a target-shaped PPD reaction

1 Saez M, Rodriguez-Martin M, Sidro-Sarto M et al. Multiple verrucae vulgaris in a young woman’s tattoo. J Eur Acad Dermatol Venereol 2006; 20: 356–357. 2 Levy J, Sewell M, Goldstein N. II. A short history of tattooing. J Dermatol Surg Oncol 1979; 5: 851–856. 3 Gilson CC. Ethical and legal aspects of illustrative clinical recording. Br J Hosp Med 1994; 52: 225–229. 4 Hood CA, Hope T, Dove P. Videos, photographs, and patient consent. BMJ 1998; 316: 1009–1011. 5 Kluger N, Aractingi S. Sarcoidosis in tattoos in chronic hepatitis virus C. Presse Med 2006; 35: 1668–1669. 6 Kluger N, Comte C, Guillot B. Molluscum contagiosum on a tattoo. Ann Dermatol Venereol 2007; 134: 506–507.

Besinlerle Yapılan Atopi Yama Testinin SCORAD İle İlişkisi

Amaç: Besinlerle atopik dermatit (AD) kliniği arasındaki ilişki tartışmalıdır.Besinlerle yapılan “fresh prick testleri”nin (FPT) özgünlüğünün düşük olması, AD’de çoğunlukla lezyonların geç ortaya çıkması ve buna bağlı anamnezdeki tutarsızlıklar, provokasyon testinin zaman alıcı ve riskli olması, hastalığın fizyopatolojisinde T lenfositlerin oynamış olduğu rol, atopi yama testini (APT: “Atopy Patch Test”) ön plana çıkartmaktadır. Bu çalışmada besinlerle yapılan APT ve FPT’nin hastalığın ağırlığını yansıtan SCORAD indeksi ile olan ilişkisi araştırılmıştır. Gereç ve Yöntem: Çalışmaya Mayıs 2006-Mayıs 2007 tarihleri arasında polikliniğimizde AD tanısı alan, yaşları 2–15 yaş arasında 21’i erkek, 24’ü kız 45 hasta dahil edildi. Tüm hastalara yumurta, süt ve buğday unu ile FPT ve APT uygulandı. Hastalığın şiddeti SCORAD indeksi kullanılarak değerlendirildi. Çalışmanın istatistiksel analizinde SPSS sürüm 11.0. istatistik paket programı kullanıldı. P<0,05 ise istatistiksel olarak anlamlı kabul edildi. Bulgular: Besinlerle yapılan FPT hastaların %32,5’inde pozitif, %67,5’inde negatif olarak bulundu. En yüksek besin FPT pozitifliği %20 ile buğday ununa karşı gözlendi. Besinlere karşı 21 (%56,8) hastada pozitif APT reaksiyonu vardı. Besinlerle en yüksek APT pozitifliği yumurtaya karşı (%54,1) gözlendi. SCORAD indeksi ile besin allerjenlerine karşı FPT pozitifliği arasında anlamlı ilişki gözlenmedi. Aynı şekilde besinlerle yapılan APT ile SCORAD indeksi arasında ilişki saptanmadı. Sonuç: Çalışmamızda besinlerle allerji testleri pozitifliklerinin AD’nin klinik şiddetini yansıtan parametrelerle ilişkisi gözlenmedi. Özellikle besin APT sonuçlarına göre eliminasyon diyeti kararı vermenin uygun olmadığını düşünmekteyiz. (Türk derm 2013; 47: 99-102) Anah tar Ke li me ler: Atopik dermatit, atopi yama test, skin prick test, SCORAD

Leonardo da Vinci: renaissance and humanity

who died in 1986. This movie genius, deeply influenced by Leonardo da Vinci, said that; ‘It is possible to be approached by Leonardo da Vinci’s paintings with sharply contrasting sensations.. .’ [2 ] . I congratulate the authors on having written such an excellent article. [ l ] Marchetti C, Panconesi E. Leonardo da Vinci: beauty of human suffering in the world. Notes on pathological cutaneous alterations in the ‘Adoration of the Magi’, J Eur Acad Dermatol Venereol 1997;8:101-111.