Olaf Gabbert

Clinical performance of extended zirconia frameworks for fixed dental prostheses: two-year results

The purpose of this prospective cohort study was to assess the performance of tooth-supported, extended zirconia, fixed dental prostheses (FDPs). Thirty FDPs with span-lengths between 36 and 46 mm (mean: 40.33 mm), four to seven units and with connector dimensions of approximately 9 mm(2) were inserted (19 in the posterior region, 11 including anterior teeth) using glass-ionomer cement and assessed (aesthetic evaluation, failures, hypersensitivity/tooth vitality, secondary caries, pocket depth, decementation and chipping) at baseline and after 2 years. Differences between baseline and 2-year recall were analysed using the Wilcoxon signed-rank test for matched pairs. There were five failures. One FDP revealed a core fracture at the base of the connector, probably caused by a damage induced during fabrication. Two FDPs had to be recemented, one abutment tooth had to be treated endodontically and one cohesive failure of the veneer was observed. There were no significant changes of pocket depth and hypersensitivity between baseline and 2-year recall. The aesthetics were rated as excellent by the patients at both baseline and recall. Two year clinical results of extended zirconia based FDPs with 9 mm(2) connectors are promising.

All-ceramic inlay-retained fixed partial dentures: Preliminary results from a clinical study

OBJECTIVES The objective of this study was to evaluate the clinical performance of zirconia-based all-ceramic fixed partial dentures anchored by inlays. METHODS A total of thirty FPDs, manufactured using a zirconia frame and veneered with press ceramic, were anchored by use of inlay retainers. All FPDs were designed to replace one missing molar and were adhesively luted by use of one of two different resin cements. Documentation included failures and other complications, plaque accumulation, and aesthetic and functional performance. Statistical analysis was performed using a cox-regression model. RESULTS During the 12 months observation period a total of thirteen clinically relevant complications occurred-four delaminations of the veneer and six decementations. Three FPDs had to be replaced because of a fracture of the framework. The cement chosen, the location, and the design of the retainer had no statistically significant effect on the occurrence of complications. During the observation period, accumulation of plaque on the abutment teeth was not significantly greater than on reference teeth. Postoperative sensitivity did not differ significantly between the different luting cement groups. The aesthetic and functional performance of the FPDs was acceptable. CONCLUSIONS Improved adhesion between resin cement and inlay retainer is desirable before general recommendation of all-ceramic inlay-retained FPDs. Use of different luting cements seems to have no effect on the occurrence of complications.

Clinical performance of long-span zirconia frameworks for fixed dental prostheses: 5-year results

The purpose of this prospective cohort study was to assess the performance of tooth-supported, long-span, zirconia fixed dental prostheses (FDPs). Thirty FDPs with span lengths from 36 to 46 mm (mean 40·33 mm), with 4-7 units and with connector dimensions ∼9 mm(2) were inserted (19 in the posterior region, 11 including anterior teeth) using glass-ionomer cement. The performance of the FDPs was assessed (aesthetic evaluation, failures, hypersensitivity/tooth vitality, secondary caries, pocket depth, decementation, and chipping) at baseline and after 5 years. Cox regression analysis was performed to identify risk factors. There were 16 failures after 5 years. Framework fracture occurred for two FDPs, four FDPs had to be re-cemented, one abutment tooth had to be treated endodontically, one abutment tooth fractured and cohesive failure of the veneer occurred for eight. Four FDPs had to be replaced, so survival was 82%. The aesthetics were rated as excellent by the patients at baseline and good at the 5-year recall. Cox regression analysis showed that both length [P = 0·05, exp(B) = 1·22] and location [P = 0·019, exp(B) = 4·09] of the FDP were risk factors for failure. Compared with the previously published 2-year results, the incidence of complications increased dramatically. Additionally, it was shown that long-span FDPs in the molar region are at greater risk of failure than FDPs in the anterior region.

Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth.

In humans, pathogenesis in cyclosporine A (CsA)-induced gingival overgrowth (GO) includes the accumulation of extracellular matrix (ECM) constituents, viz., collagen type-1 and type-3 and proteoglycans, in subgingival connective tissue. However, whether this increase is associated with alterations of molecules pivotal for the turn-over of collagens and proteoglycans remains unclear. The present study explores the status of matrix metalloproteinase MMP-1 and MMP-10, which are important for fibrillar collagen and proteoglycan turn-over, and their tissue inhibitor TIMP-1, on their gene expression and protein levels in frozen sections derived from GO and matched normal tissue. In situ hybridization (ISH) revealed elevated levels of MMP-1 gene expression in the connective tissue of GO compared with normal tissue. This elevation also applied to MMP-10 and TIMP-1, the latter exhibiting the strongest gene transcription in the deep connective tissue. These differences detected by ISH were corroborated by quantitative reverse transcription/polymerase chain reaction; relative gene expression analysis indicated a 1.9-fold increase for MMP-1, a 2.3-fold increase for MMP-10, and a 4.8-fold increase for TIMP-1. Detection of the protein by indirect immunofluorescence showed that normal gingival tissue was devoid of all three proteins, although they were detectable in GO tissue, with emphasis on TIMP-1. Analysis of our data indicates elevated levels of MMP-1 and-10, and particularly TIMP-1. With respect to TIMP-1, this elevation may in turn lead to alterations in ECM turn-over by abrogating MMP-1 and MMP-10, thereby contributing to ECM accumulation associated with GO.

Early loading of implants with fixed dental prostheses in edentulous mandibles: 4.5‐year clinical results from a prospective study

AIM The purpose of this study was to evaluate the survival and success of early-loaded implants placed in the intraforaminal area of the edentulous mandible, and the survival of the implant-supported fixed dental prostheses (FDP). MATERIAL AND METHODS Thirty-seven patients (18.9% male, mean age 64.5 years) with edentulous lower jaws were treated with implant-supported FDPs in the mandible. One hundred and eighty-five screw-type implants were placed in the intraforaminal area of the symphysis (five implants per patient). Immediately after implant placement, a framework was fabricated and the FDP was manufactured on the framework. Within 2 weeks, the implants were rigidly connected and loaded with the implant-retained FDP. RESULTS During the 1-8-year observation period (mean 4.5 years), a total of 32 implant-retained complications occurred. Nineteen implants were lost in 10 patients, resulting in a cumulative survival of 89.7%. Nine implants in five patients did not osseointegrate. Although these implants were not removed, because stability within the connective tissue was acceptable and inflammation was absent, they were recorded as unsuccessful. Consequently, the cumulative success declined to 84.9%. Four implants in three patients had clinical signs of periimplantitis (2.2% of all implants). Denture-related complications included one complete failure, when one FDP had to be removed after the last of five implants had been replaced. Furthermore, 10 fractures of the framework occurred in six patients, three FDPs had to be adapted or modified, and the facing of the FDP had to be repaired 16 times in 11 patients. CONCLUSION Although one-stage early-loaded implants functioned well for most patients with edentulous mandibles, immediate loading is associated with a larger number of implant-related complications than in other studies investigating delayed loading. Because of the substantial prosthetic complications and aftercare, this procedure cannot be generally recommended.

Fracture resistance of the veneering on inlay-retained zirconia ceramic fixed partial dentures

Aims. The aim of this in vitro study was to evaluate the fracture load of zircon frames veneered with a polymer glass holding box inlay-retained fixed partial dentures (FPDs). The influence of the position of the frame and the span length was tested. Additionally, the fracture load values of zircon frames veneered with a press ceramic were evaluated. Material and methods. Box inlay cavities were prepared on mandibular molars and premolars. Forty-eight FPDs were manufactured using industrially prefabricated zircon frames veneered with the polymer glass Artglass®. Sixteen FPDs received individually manufactured CAD/CAM zircon frames veneered with a press ceramic. All FPDs underwent thermal cycling and mechanical loading (ML). The load to fracture was measured and fracture sites were evaluated. Results. Four polymer veneered FPDs showed fractures in the veneering material after ML. The mean fracture resistance ranged from 531 N to 727 N. No significant influence of frame localization could be observed. Significantly greater fracture resistance values were found in the ceramic veneered FPDs (1276 N to 1413 N). There was no significant effect of span length in the polymer veneered group or in the all-ceramic group, with the exception of a significant peak in fracture load value for intermediate span lengths in the polymer group with a localized occlusal zircon frame. Conclusions. Polymer veneered FPDs with Y-TZP frames showed acceptable fracture resistance values, but they cannot yet be unreservedly recommended for clinical use. Fracture values for CAD/CAM manufactured Y-TZP frames combined with a press ceramic deserve further clinical investigation.

Fracture behaviour of zirconia ceramic cantilever fixed dental prostheses in vitro.

Objective. Evaluation of the fracture resistance of all-ceramic cantilever fixed dental prostheses (FDPs) manufactured from zirconia frameworks and veneered with a press ceramic. Material and Methods. Two mandibular premolars were prepared either with a box inlay cavity or with a full crown chamfer preparation and then duplicated. 40-three-unit cantilever FDPs replacing one premolar, with a group size of eight for each design, were manufactured. In group i-i the cantilever FDPs were retained by two inlays, in group i-c by an inlay–crown combination, and in group c-c by two crowns. The frameworks in groups i-c-R and c-c-R were reinforced by an additional shoulder on the oral side of the zirconia frameworks. All FDPs were subjected to thermal cycling (TC) and 600,000 cycles of mechanical loading (ML) with 50 N. The load to fracture was measured and fracture sites were evaluated. Results. The mean fracture values ranged from 172 N to 792 N. Fracture-strength values were significantly lower for the i-i retained FDPs than for the i-c and c-c combinations. There was no significant effect of the reinforcing shoulder in groups i-c-R and c-c-R. For FDPs with a crown on the terminal tooth, fractures were usually within the distal wall of the distal crown. Conclusions. Inlay–inlay retained cantilever FDPs cannot withstand the mastication forces expected. Fracture load values for inlay–crown and crown–crown-retained FDPs encourage further clinical investigation. The mode of fracture indicates that reinforcement of the distal crown wall might enhance fracture resistance.

Temporomandibular disorders in association with scuba diving.

Objective:To determine the prevalence of temporomandibular disorders (TMD) in scuba divers and to identify the risk factors for the development of pain in the stomatognathic system before and after diving by the use of a questionnaire. Design:Retrospective cohort study based on questionnaires. Participants:A total of 296 active divers, aged 18 to 65 years, participating in scuba diving meetings in Heidelberg, Germany. Interventions:Each diver answered a questionnaire containing 29 questions, predominantly on symptoms of TMD. Main Outcome Measures:The data collected from the divers were calculated by the use of logistic regression tests. Risk factors for the development of TMD were evaluated. Results:Clenching seemed to be the greatest risk factor for pain while holding the mouthpiece and for pain in the masticatory muscle system after diving. Limited mouth opening and clenching were responsible for the development of pain in the temporomandibular joint after the dive. The prevalence of TMD-related symptoms was higher in women before, during, and after the dive. Conclusions:Individuals exhibiting TMD-related symptoms seem to be at the greatest risk of developing pain in the masticatory muscle system and/or the temporomandibular joint during or after the dive.

Wear of posterior metal-free polymer crowns after 2 years.

The objective of this study was to evaluate the clinical wear behaviour of posterior, metal-free polymer crowns and to compare it with that of metal-ceramic crowns. After randomization, a total of 120 single crowns were set in posterior teeth. These 120 crowns were divided into three groups: 40 polymer crowns with a glass-fibre framework (group 1), 40 polymer crowns without framework stabilization (group 2) and 40 metal-ceramic crowns (control group). Wear was measured by use of gypsum replicas and a 3D laser scanner at baseline and after 2 years. Statistical analysis was performed by use of a mixed-effects regression model. The mean total wear of posterior single crowns was -19.0 mum (+/- 18.5 microm) in group 1, -24.3 microm (+/- 31.5 microm) in group 2 and -7.0 microm (+/- 8.8 microm) in the control group. Statistical analysis revealed the mean total wear of the polymer crowns in groups 1 (P < or = 0.01) and 2 (P < or = 0.01) was significantly greater than in the control group. No significant difference was detected between groups 1 and 2 (P = 0.58). Age, gender and opposing teeth had no significant effect on wear behaviour.

Fracture load of tooth–implant‐retained zirconia ceramic fixed dental prostheses: effect of span length and preparation design

OBJECTIVES Evaluation of the effect of different span length and preparation designs on the fracture load of tooth-implant-supported fixed dental prostheses (TIFDPs) manufactured from yttrium-stabilized zirconia frameworks. MATERIAL AND METHODS Forty-eight TIFDPs were manufactured using a CAD/CAM system and veneered with a press ceramic. Rigidly mounted implants (SLA, diameter 4.1 mm, length 10 mm) in the molar region with a titanium abutment were embedded in PMMA bases pairwise with premolars. All premolars were covered with heat-shrink tubing to simulate physiological tooth mobility. Six different test groups were prepared (a) differing in the preparation design of the premolar (inlay [i]; crown [c]), (b) the material of the premolar (metal [m]; natural human [h]) and (c) the length of the TIFDPs (3-unit [3]; 4-unit [4]). All TIFDPs underwent thermomechanical loading (TCML) (10,000 × 6.5°/60°; 6 × 10(5) × 50 N). The load to fracture (N) was measured and fracture sites were evaluated macroscopically. RESULTS None of the restorations failed during TCML. The mean fracture loads (standard deviations) were 1,522 N (249) for the 3-unit, inlay-retained TIFDPs on a metal abutment tooth (3-im), 1,910 N (165) for the 3-cm group, 1,049 N (183) for group 4-im, 1,274 N (282) for group 4-cm, 1,229 N (174) for group 4-ih and 911 N (205) for group 4-ch. Initial damages within the veneering ceramic occurred before the final failure of the restoration. The corresponding loads were 24-52% lower than the fracture load values. CONCLUSIONS All restorations tested could withstand the mastication forces expected. Fracture-load values for 3- and 4-unit inlay-crown and crown-crown-retained TIFDPs should spur further clinical investigation.