Oleg Kuznetsov

New ferro-carbon adsorbents for magnetically guided transport of anti-cancer drugs

Abstract The plasmachemical technology of iron–carbon adsorbent production was developed and optimized. The adsorbent was thoroughly studied by physical, chemical and biological methods, and was found to have high sorption capacity, long desorption time, high magnetization and low toxicity. The adsorbent is intended to be used for magnetically guided transport and forming a depot of anti-cancer drugs in the tumor zone.

Correlation of the coagulation rates and toxicity of biocompatible ferromagnetic microparticles

Interaction of four types of ferromagnetic microparticles with solid phase surfaces in biological media was studied and their acute toxicity compared. Stability of the colloidal system was found to depend on the surface properties, composition and structure of the particles and the solid phase. Increase in stability of the sol leads to decrease in toxicity of the particles.

Metal-organic magnetic materials based on cobalt phthalocyanine and possibilities of their application in medicine

Cobalt phthalocyanines (CoPc), doped with sodium, exhibit ferromagnetic ordering at room temperature. Magnetic dilution or variation in dopant concentration leads to the formation of new magnetic materials. A proposed scheme of oncological disease treatment includes magnetic concentration of CoPc particles in the tumor zone and ascorbic acid injection into the organism for stimulation of oxidation reactions, which destroy the tumor.

Thermodynamics behind Carbon Nanotube Growth via Endothermic Catalytic Decomposition Reaction

Carbon filaments can be grown using hydrocarbons with either exothermic or endothermic catalytic decomposition enthalpies. By in situ monitoring the evolution of the reaction enthalpy during nanotube synthesis via methane gas, we found that although the decomposition reaction of methane is endothermic an exothermic process is superimposed which accompanies the nanotube growth. Analysis shows that the main contributor in this liberated heat is the radiative heat transfer from the surroundings, along with dehydrogenation reaction of in situ formed secondary hydrocarbons on the catalyst surface and the carbon hydrogenation/oxidation processes. This finding implies that nanotube growth process enthalpy is exothermic, and particularly, it extends the commonly accepted temperature gradient driven growth mechanism to the growth via hydrocarbons with endothermic decomposition enthalpy.

New Method of Biological Fluid Detoxification Based on Magnetic Adsorbents

Existing methods of human organism detoxification such as hemoperfusion, hemodialysis and plasmapheresis are of low efficiency, damage cellular elements of blood, and require a significant volume of blood, complex and expensive hardware. We used finely dispersed magnetic adsorbents for hemosorption. A suspension of such particles, injected into an extracorporeal system, moves with the bloodstream and leads, due to the large specific surface of the magnetic adsorbents, to a fast and effective sorption process. The small size of the particles and very short and simple extracorporeal system does not damage cellular blood elements. Magnetic particles are then removed by a high gradient magnetic separator and the purified blood is returned to the organism. Effectiveness of the method was tested, and adsorbents for low, medium and high molecular weight compounds were selected. Animal experiments showed the high effectiveness of the technique for the removal of low-molecular weight toxins (barbiturates).