Olga A. Mostovaya

Interaction of Vinylphosphonates with 1,2-Diaminoethane and Ethanolamine

The reaction of 1,2-diaminoethane with vinylphosphonate occurs as the addition of the amino group to the β -carbon atom of the unsaturated substrate to give 1:1 and 1:2 adducts. The nucleophilic addition of 2-aminoethanol at the β -position of the double bond of vinylphosphonates involves only the amino group and leads to the formation of hydroxy β -aminoethylphosphonates or zwitterions depending on conditions.

Tetracarboxylic acids on a thiacalixarene scaffold: synthesis and binding of dopamine hydrochloride

For the first time thiacalix[4]arene derivatives in 1,3-alternate conformation simultaneously containing amide, carboxyl and hydroxyl groups capable of forming 1 : 1 stoichiometry complexes with dopamine hydrochloride were obtained. The efficiency of dopamine hydrochloride binding was evaluated by a number of spectral methods. Using the methods of fluorescent, UV-Vis and NMR spectroscopy, the mechanism of interaction of the synthesized macrocycles with dopamine has been studied. It was shown that quenching of dopamine fluorescence by the studied macrocycles is carried out through a static mechanism.

Self-assembly of chiral fluorescent nanoparticles based on water-soluble L-tryptophan derivatives of p-tert-butylthiacalix[4]arene

New water-soluble tetra-substituted derivatives of p-tert-butylthiacalix[4]arene containing fragments of L-tryptophan in cone and 1,3-alternate conformations were obtained. It was shown that the resulting compounds form stable, positively charged aggregates of 86–134 nm in diameter in water at a concentration of 1 × 10−4 M as confirmed by dynamic light scattering, scanning electron microscopy and transmission electron microscopy. It was established that these aggregates are fluorescently active and chiral. A distinctive feature of the compounds is the pronounced dependence of their spectral (emission and chiroptical) properties on the polarity of the solvent and the length of the linker between the macrocyclic and fluorophore parts of the molecule.

Synthesis of new tris(1-amino)phosphonates based on tris(2-aminoethyl)amine

GRAPHICAL ABSTRACT ABSTRACT New aminophosphonate derivatives of tris(2-aminoethyl)amine were synthesized. The structures of the newly synthesized derivatives were fully proven by 1H, 31P, 13C NMR, IR spectroscopy, mass spectrometry (MALDI-TOF), and elemental analysis.

Reaction of a 2H-1,2,3-Diazaphosphole with Ethane-1,2-Dithiol

Abstract Reaction of 2-acetyl-5-methyl-2H-1,2,3-diazaphosphole with ethane-1,2-dithiol at −30°C leads to the formation of 2-acetyl-3-(β-mercaptoethylthio)-5-methyl-1,2,3-diaza-phospholene. On heating, this product forms 2-(β-mercaptoethylthio)-1,3,2-dithia-phospholane, 1,2-bis(1,3,2-dithiaphospholanyl)-dithioethane, and N-acetyl-N′-isopropilidene-hydrazine. GRAPHICAL ABSTRACT