Olga Malsam
Bayer
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Olga Malsam.
Bioorganic & Medicinal Chemistry | 2009
Jens Frackenpohl; Isabelle Adelt; Horst Antonicek; Christian Arnold; Patricia Behrmann; Nicole Blaha; Jutta Böhmer; Oliver Gutbrod; Roman Hanke; Sabine Hohmann; Marc van Houtdreve; Peter Lösel; Olga Malsam; Martin Melchers; Valentina Neufert; Elisabeth Peschel; Udo Reckmann; Thomas Schenke; Hans-Peter Thiesen; Robert Velten; Kathrin Vogelsang; Hans-Christoph Weiss
Starting from natural product podophyllotoxin 1 substituted heterolignans were identified with promising insecticidal in vivo activity. The impact of substitution in each segment of the core structure was investigated in a detailed SAR study, and variation of substituents in both aromatic moieties afforded derivatives 5 and 43 with broad insecticidal activity against lepidopteran and coleopteran species. In vitro measurements supported by modeling studies indicate that heterolignans 3-134 act as tubuline polymerization inhibitors interacting with the colchicine-binding site. Insect specific structure-activity effects were observed showing that the insecticidal SAR described herein differs from reported cytotoxicity studies.
Archive | 2007
Peter Jeschke; Robert Velten; Thomas Schenke; Otto Schallner; Michael Edmund Beck; Rolf Pontzen; Olga Malsam; Udo Reckmann; Ralf Nauen; Ulrich Görgens; Leonardo Pitta; Thomas Müller; Christian Arnold; Erich Sanwald
Archive | 2006
Thomas Bretschneider; Reiner Fischer; Oliver Gaertzen; Stefan Lehr; Mark Wilhelm Drewes; Dieter Feucht; Olga Malsam; Udo Reckmann; Christian Arnold; Thomas Auler; Waltraud Hempel; Martin Jeffrey Hills; Heinz Kehne; Christopher Hugh Rosinger; Erich Sanwald
Archive | 2007
Peter Jeschke; Robert Velten; Thomas Schenke; Otto Schallner; Michael Edmund Beck; Olga Malsam; Ralf Nauen; Thomas Müller; Christian Arnold; Erich Sanwald; Ulrich Görgens
Archive | 2007
Thomas Bretschneider; Reiner Fischer; Rolf Pontzen; Christian Arnold; Ulrich Görgens; Olga Malsam; Udo Reckmann; Erich Sanwald; Stefan Lehr; Jan Dittgen; Dieter Feucht; Martin Jeffrey Hills; Christopher Hugh Rosinger
Archive | 2003
Thomas Himmler; Reiner Fischer; Bernd Gallenkamp; Hans-Joachim Knops; Lubbertus Mulder; Christoph Erdelen; Joerg Konze; Ralf Nauen; Olga Malsam; Christian Arnold
Archive | 2004
Reiner Fischer; Klaus Kunz; Stefan Lehr; Michael Ruther; Udo Schneider; Markus Dollinger; Mark Wilhelm Drewes; Dieter Feucht; Jörg Konze; Ulrike Wachendorff-Neumann; Guido Bojack; Thomas Auler; Martin Jeffrey Hills; Thomas Bretschneider; Olga Malsam; Christoph Di Erdelen; Alfred Angermann; Heinz Kehne; Christopher Hugh Rosinger
Archive | 2004
Reiner Fischer; Astrid Ullmann; Thomas Bretschneider; Stefan Lehr; Klaus Kunz; Jörg Konze; Olga Malsam; Mark Wilhelm Drewes; Dieter Feucht; Karl-Heinz Kuck; Ulrike Wachendorff-Neumann; Wahed Ahmed Moradi; Guido Bojack; Thomas Auler; Martin Jeffrey Hills; Heinz Kehne
Archive | 2009
Thomas Bretschneider; Eva-Maria Franken; Ulrich Görgens; Martin Füsslein; Achim Hense; Joachim Kluth; Hans-Georg Schwarz; Adeline Köhler; Olga Malsam; Arnd Voerste; Angela Becker
Archive | 2009
Rüdiger Fischer; Christian Funke; Ernst Rudolf F. Gesing; Christoph Grondal; Achim Hense; Angela Becker; Eva-Maria Franken; Olga Malsam; Arnd Voerste; Ulrich Görgens; Heinz-Juergen Wroblowsky
