Olga Pierrakos

The Effect of Vortex Formation on Left Ventricular Filling and Mitral Valve Efficiency

A new mechanism for quantifying the filling energetics in the left ventricle (LV) and past mechanical heart valves (MHV) is identified and presented. This mechanism is attributed to vortex formation dynamics past MHV leaflets. Recent studies support the conjecture that the natural healthy left ventricle (LV) performs in an optimum, energy-preserving manner by redirecting the flow with high efficiency. Yet to date, no quantitative proof has been presented. The present work provides quantitative results and validation of a theory based on the dynamics of vortex ring formation, which is governed by a critical formation number (FN) that corresponds to the dimensionless time at which the vortex ring has reached its maximum circulation content, in support of this hypothesis. Herein, several parameters (vortex ring circulation, vortex ring energy, critical FN, hydrodynamic efficiencies, vortex ring propagation speed) have been quantified and presented as a means of bridging the physics of vortex formation in the LV. In fact, the diastolic hydrodynamic efficiencies were found to be 60, 41, and 29%, respectively, for the porcine, anti-anatomical, and anatomical valve configurations. This assessment provides quantitative proof of vortex formation, which is dependent of valve design and orientation, being an important flow characteristic and associated to LV energetics. Time resolved digital particle image velocimetry with kilohertz sampling rate was used to study the ejection of fluid into the LV and resolve the spatiotemporal evolution of the flow. The clinical significance of this study is quantifying vortex formation and the critical FN that can potentially serve as a parameter to quantify the LV filling process and the performance of heart valves.

Time-Resolved DPIV Analysis of Vortex Dynamics in a Left Ventricular Model Through Bileaflet Mechanical and Porcine Heart Valve Prostheses

The performance of the heart after a mitral valve replacement operation greatly depends on the flow character downstream of the valve. The design and implanting orientation of valves may considerably affect the flow development. A study of the hemodynamics of two orientations, anatomical and anti-anatomical, of the St. Jude Medical (SJM) bileaflet valve are presented and compared with those of the SJM Biocor porcine valve, which served also to represent the natural valve. We document the velocity field in a flexible, transparent (LV) using time-resolved digital particle image velocimetry (TRDPIV). Vortex formation and vortex interaction are two important physical phenomena that dominate the filling and emptying of the ventricle. For the three configurations, the following effects were examined: mitral valve inlet jet asymmetry, survival of vortical structures upstream of the aortic valve, vortex-induced velocities and redirection of theflow in abidance of the Biot-Savart law, domain segmentation, resonant times of vortical structures, and regions of stagnantflow. The presence of three distinct flow patterns, for the three configurations, was identified by the location of vortical structures and level of coherence corresponding to a significant variation in the turbulence level distribution inside the LV. The adverse effect of these observations could potentially compromise the efficiency of the LV and result in flow patterns that deviate from those in the natural heart.

Effect of Stent Design Parameters on Fluid and Structural Mechanics in Coronary Arteries

As undergraduates at Virginia Polytechnic Institute and State University, our senior design team has been developing new arterial stent designs using computational, experimental and flow characterizations. Coronary artery stenting has become a popular alternative to bypass surgery due to its relatively low cost and short recovery time. There are approximately one million of these procedures performed each year. At the beginning of 2006, drug eluting stents (DES) accounted for 90% of stenting procedures; this number dropped below 75% by the end of 2006. The initial popularity of DES was due to their effective reduction in restenosis compared to the first generation of stents, bare-metal stents. Recently, the makers of DES have agreed that, compared with bare-metal stents, there is a small, but significant increase in the rate of stent thrombosis for both the Cypher (Johnson & Johnson) and Taxus (Boston Scientific) stents, beginning about 12 months after implantation [1].© 2007 ASME