Olivier Putois

A Lacanian approach to medical demand, with a focus on pediatric genetics: a plea for subjectivization

Current psychological research on contemporary medicine, and in particular genetics, often targets the underpinnings of patients’ attitudes and behaviors with respect to biomedical knowledge and healthcare practices. But few studies approach these underpinnings as manifestations of the unconscious, while so doing could (in particular) help understand patients’ apparent difficulties to understand information, and to subsequently act accordingly (e.g., in making therapeutic decisions, etc.). We hypothesize that Lacan’s (1966) remarks (“The place of psychoanalysis in medicine”) on the transferential nature of the demand addressed by the patient (or his family) to the doctor can help account for these issues: demand filters medical information received from the practitioner, and thereby motivates subsequent decisions. In this paper, we try and shed light on this thesis, and focus on pediatric genetics. We start by describing the manifest doctor-patient-family relationship in the pediatric genetics consultation, in order to show where unconscious determinants can come to play a role (1). We then explain Lacan’s theory of demand: what the patient unknowingly demands is knowledge (savoir), the object of which is the body of jouissance – the libidinal experience of one’s body through the first libidinal exchanges with the Other of early infancy, whereby the subject is assigned by the Other (subjectification) a specific fantasmatic status organizing his desire. Patients’ understanding and attitudes thus vary so greatly because of this pre-existing filter. Healing and cure are merely apparent objects of the medical demand, which is an invocative drive seeking knowledge on the cause of one’s desire: medical demand is an instance of transference. Doctors should thus enable patient subjectivization, i.e., help them realize that their demand’s genuine object lies in their pre-existing subjective coordinates (2). In pediatric genetics, apparently paradoxical family attitudes heavily draw on what G. Raimbault, drawing on Lacan, called implicit demand, the object of which is knowledge about the family fantasy giving shape to the guilt of possibly transmitting the disease. We give a clinical example, then show how the concept of demand helped us elaborate the core of a research project on the subjective effects of a genetic deafblindness handicap (3).

Secondary findings from whole-exome/genome sequencing evaluating stakeholder perspectives. A review of the literature

With the development of next generation sequencing, beyond identifying the cause of manifestations that justified prescription of the test, other information with potential interest for patients and their families, defined as secondary findings (SF), can be provided once patients have given informed consent, in particular when therapeutic and preventive options are available. The disclosure of such findings has caused much debate. The aim of this work was to summarize all opinion-based studies focusing on SF, so as to shed light on the concerns that this question generate. A review of the literature was performed, focusing on all PubMed articles reporting qualitative, quantitative or mixed studies that interviewed healthcare providers, participants, or society regarding this subject. The methodology was carefully analysed, in particular whether or not studies made the distinction between actionable and non-actionable SF, in a clinical or research context. From 2010 to 2016, 39 articles were compiled. A total of 14,868 people were interviewed (1259 participants, 6104 healthcare providers, 7505 representatives of society). When actionable and non-actionable SF were distinguished (20 articles), 92% of respondents were keen to have results regarding actionable SF (participants: 88%, healthcare providers: 86%, society: 97%), against 70% (participants: 83%, healthcare providers: 62%, society: 73%) for non-actionable SF. These percentages were slightly lower in the specific situation of children probands. For respondents, the notion of the «patients choice» is crucial. For healthcare providers, the importance of defining policies for SF among diagnostic lab, learning societies and/or countries is outlined, in particular regarding the content and extension of the list of actionable genes to propose, the modalities of information, and the access to information about adult-onset diseases in minors. However, the existing literature should be taken with caution, since most articles lack a clear definition of SF and actionability, and referred to hypothetical scenarios with limited information to respondents. Studies conducted by multidisciplinary teams involving patients with access to results are sadly lacking, in particular in the medium term after the results have been given. Such studies would feed the debate and make it possible to measure the impact of such findings and their benefit-risk ratio.

Guidelines for reporting secondary findings of genome sequencing in cancer genes: the SFMPP recommendations

In oncology, the expanding use of multi-gene panels to explore familial cancer predisposition and tumor genome analysis has led to increased secondary findings discoveries (SFs) and has given rise to important medical, ethical, and legal issues. The American College of Medical Genetics and Genomics published a policy statement for managing SFs for a list of genes, including 25 cancer-related genes. Currently, there are few recommendations in Europe. From June 2016 to May 2017, the French Society of Predictive and Personalized Medicine (SFMPP) established a working group of 47 experts to elaborate guidelines for managing information given on the SFs for genes related to cancers. A subgroup of ethicists, lawyers, patients’ representatives, and psychologists provided ethical reflection, information guidelines, and materials (written consent form and video). A subgroup with medical expertise, including oncologists and clinical and molecular geneticists, provided independent evaluation and classification of 60 genes. The main criteria were the “actionability” of the genes (available screening or prevention strategies), the risk evaluation (severity, penetrance, and age of disease onset), and the level of evidence from published data. Genes were divided into three classes: for class 1 genes (n = 36), delivering the information on SFs was recommended; for class 2 genes (n = 5), delivering the information remained questionable because of insufficient data from the literature and/or level of evidence; and for class 3 genes (n = 19), delivering the information on SFs was not recommended. These guidelines for managing SFs for cancer-predisposing genes provide new insights for clinicians and laboratories to standardize clinical practices.

Less Citation, Less Dissemination: The Case of French Psychoanalysis

We contribute to inquiries about the visibility of globalized psychoanalytic research in the digital era (cf. Stepansky 2009) by adopting a comparative perspective on a specific geographic area of historical importance for psychoanalysis: France. The largely digital globalized psychoanalytic research field relies on standard bibliometric measures of journal quality (Impact Factor, SJR, etc.), which depend on the number and type of academic cites received by a journal. Thus, citing shapes academic publishing space by differentially valuing its component journals. Conversely, not to cite practically means not to engage with the field. Hence, we took citedness rate as a proxy for global visibility. By drawing on an original database created by one of us, we determined the global citational visibility of French vs. Anglo- American psychoanalytic productions (respective global outreach); and we related it to a first look at French vs. Anglo-American citation practices (geographic breakdown of article cites). We found that, on a 15-year period, the global outreach (citedness rate) of French articles is ten times smaller than that of Anglo- American articles; and that French articles are cited in Anglo-American journals five times more than Anglo-American articles in French journals – which in turn don’t seem to cite their French peers very often. These specific French citation practices could be explained by the implicit modes of reference at work in clinical settings shaped by rich theoretical and clinical local legacies. We conclude by considering that this situation presents French psychoanalytic research with a formidable opportunity for increased citational visibility.

Lost in post‐translation

The names we choose to describe or define biological concepts can have a huge impact on the way we think. It is time to reflect on whether certain terms, even those as fundamental as “translation”, are still appropriate for the scientific lexicon.