Oluseye Ogunmoroti

Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review

BACKGROUND Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits proinflammatory properties and has been associated with subclinical cardiovascular disease. OBJECTIVE The relationship between Lp-PLA2 and subclinical CVD remains unclear. The goal of this systematic review was to clarify this relationship. METHODS An extensive literature search of the MEDLINE database using Ovid and PubMed was performed. From an initial search of 444 articles, 13 met the inclusion and exclusion criteria and were included in the review. RESULTS Of the 13 studies included in the review, 6 examined the relationship between Lp-PLA2 and coronary artery calcification, of which 3 showed a significant correlation. Two studies examined the relationship between Lp-PLA2 and endothelial dysfunction, and 1 reported a significant relationship. Five studies investigated the association of Lp-PLA2 with carotid intima-media thickness (CIMT), and 3 reported a significant relationship. CONCLUSIONS This review shows a variable association between Lp-PLA2 and subclinical disease. This finding has broad implications for the future of public health and clinical practice. Future research is needed to clarify what role Lp-PLA2 has in guiding treatment and if it is involved in plaque instability, which would make it a useful tool for risk prognostication.

Favorable Cardiovascular Health Is Associated With Lower Health Care Expenditures and Resource Utilization in a Large US Employee Population: The Baptist Health South Florida Employee Study

Objective: To examine the association of favorable cardiovascular health (CVH) status with 1‐year health care expenditures and resource utilization in a large health care employee population. Participants and Methods: Employees of Baptist Health South Florida participated in a health risk assessment from January 1 through September 30, 2014. Information on dietary patterns, physical activity, blood pressure, blood glucose level, total cholesterol level, and smoking were collected. Participants were categorized into CVH profiles using the American Heart Associations ideal CVH construct as optimal (6–7 metrics), moderate (3–5 metrics), and low (0–2 metrics). Two‐part econometric models were used to analyze health care expenditures. Results: Of 9097 participants (mean ± SD age, 42.7±12.1 years), 1054 (11.6%) had optimal, 6945 (76.3%) had moderate, and 1098 (12.1%) had low CVH profiles. The mean annual health care expenditures among those with a low CVH profile was

MY UNLIMITED POTENTIAL: ACHIEVING WEIGHT, FITNESS, AND CARDIOMETABOLIC HEALTH GOALS WITH MULTICOMPONENT LIFESTYLE INTERVENTION PROGRAM EXTENDING TO 1 YEAR IN HEALTH CARE EMPLOYEES

10,104 (95% CI,

Prevalence of ideal cardiovascular health metrics in children & adolescents: A systematic review

8633‐

Abstract P258: Prevalence of Obesity and Estimated Medical and Work Loss Costs Attributable to High BMI: The Baptist Health South Florida Employee Study

11,576) compared with

Abstract 170: Racial Disparities and Patient Reported Healthcare Experience Among Adults With Atherosclerotic Cardiovascular Disease

5824 (95% CI,

Abstract 240: Association of Depression Risk With Patient Experience, Healthcare Expenditure and Health Resource Utilization Among Adults With Atherosclerotic Cardiovascular Disease

5485‐

Abstract 230: Per Capita Proportion of Total Health Care Expenditures on Pharmaceuticals Among US Adults With Cardiovascular Disease: 2012 Medical Expenditure Panel Survey

6164) and

Abstract 213: Interplay of Health-Related Quality of Life, Cardiovascular Disease and Healthcare Costs: 2012 Medical Expenditure Panel Survey

4282 (95% CI,

Abstract 244: Sex-based Differences in Economic and Health-related Burden of Depression on Adults With Cardiovascular Disease

3639‐