Oluwadamilola Ojo

Rasagiline for the symptomatic treatment of fatigue in Parkinson's disease

Fatigue affects 40% to 50% of all PD patients and is a leading cause of disability, with no clearly established or efficacious established treatments.

Influence of Age and Neurotoxic HAART Use on Frequency of HIV Sensory Neuropathy

Background. Sensory neuropathy (SN) is one of the most common AIDS-associated neurologic disorders especially in the era of highly active antiretroviral therapy (HAART). The aim of this study was to determine the prevalence of SN among highly-active-antiretroviral-therapy- (HAART-) experienced and HAART-naïve HIV-positive individuals and to investigate the relationship to demographic, clinical, and laboratory factors. Methods. 323 patients with HIV infection (142 on HAART and 181 HAART naïve) were enrolled in a cross-sectional neuropathy screening program. Data was collected using structured questionnaires which contained the brief peripheral neuropathy screening tool of AIDS Clinical Trial Group protocol. Neuropathy was defined by the presence of at least 1 clinical sign in a distal, symmetrical pattern. Patients were classified as symptomatic if they described aching, stabbing, or burning pain, paresthesia, or numbness in a similar distribution. Demographic, clinical, and laboratory details were documented as risk factors. Result. The prevalence of sensory neuropathy was 39.0% (126/323), (of which 29/126 (23%)) were symptomatic. Amongst those on HAART, 60/142 (42.3%) had SN compared to 66/181 (36.5%) HAART-naïve individuals (P = 0.29). On multivariate analyses, the independent associations with SN were increasing age (P = 0.03) and current exposure to stavudine (P = 0.00). Gender (P = 0.99) height (P = 0.07) use of HAART (P = 0.50), duration of HAART treatment (P = 0.10), and lower CD4 count (P = 0.12) were not associated with an increased SN risk. Conclusion. HIV SN remains common despite improved immunologic function associated with HAART and decreased neurotoxic HAART use. In this cross-sectional analysis, age and stavudine-based therapies were the independent risk factors.

Primary Headache Disorders at a Tertiary Health Facility in Lagos, Nigeria: Prevalence and Consultation Patterns

Background. Primary headaches are underdiagnosed and undertreated, with a significant impact on social activities and work. Aim. To determine the last-year prevalence and health care utilization pattern of primary headaches at a tertiary centre. Methods. A cross-sectional study was carried out amongst staff of the Lagos State University Teaching Hospital in Lagos, Nigeria. 402 staff members were selected by simple random sampling and administered a detailed structured headache assessment questionnaire. Migraine and tension-type headache were diagnosed according to the criteria of the International Headache Society (2004). Results. The participants comprised 168 males and 234 females. The mean age was 36.9 ± 7.9 years. The overall headache prevalence was 39.3% with female predominance (P < 0.0001). Tension-type headache was the most prevalent at 72.8% and migraine at 18.9%. Unclassifiable headache constituted 8.2%. Migraine headache showed female preponderance (P = 0.000). 80.4% of participants did not seek medical consultation compared with 19.6% who did (P = 0.000). Of the latter, 83.9% consulted the general practitioner (GP), whilst 16.1% consulted the neurologist. Conclusions. Primary headache prevalence is high in our population. It is not recognised as that requiring care by most of the staff of this tertiary health facility; thus education is required to increase health care utilization.

An Assessment of the Knowledge and Attitudes of Graduating Medical Students in Lagos, Nigeria, Regarding Obstructive Sleep Apnea

RATIONALEnSymptom scores show that a significant proportion of Nigerians are at high risk of developing obstructive sleep apnea; however, the diagnosis is rarely made in this country. The knowledge of medical students regarding sleep apnea may provide insight into their future ability to recognize patients with sleep apnea and can also inform student education on this disease.nnnOBJECTIVESnTo assess the knowledge and attitudes of graduating medical students in Nigeria regarding obstructive sleep apnea using a standard validated questionnaire.nnnMETHODSnThis descriptive, cross-sectional survey study was performed at the College of Medicine of the University of Lagos, Nigeria. The Obstructive Sleep Apnea Knowledge and Attitude (OSAKA) instrument was self-administered by the subjects. This validated questionnaire consists of 18 knowledge assessment questions and 5 attitude assessment questions.nnnMEASUREMENTS AND MAIN RESULTSnThe response rate was 99%, and our final sample comprised 143 participants. The maximum achievable knowledge score was 18. Obtained scores ranged from 0 to 15; the meanu2009±u2009SD score was 7.6u2009±u20093.2 (42.2%); and the median score was 8 (interquartile range, 6-10). Four participants (2.8%) had a score of 0, and 56 (39.2%) had a score corresponding to ≥50%. There was no significant difference in knowledge scores by sex or age. Regarding attitudes, over 80% considered obstructive sleep apnea an important disorder; 41% were confident in identifying patients with the condition; 16.1% were confident in managing the disease; and 16.8% expressed confidence in managing patients receiving continuous positive airway pressure therapy. The total attitude score ranged from 1 to 5 (mean, 2.9u2009±u20090.7). There was a significant correlation between the total attitude score and the total knowledge score (ru2009=u20090.22, Pu2009=u20090.01) and the age of the participants (ru2009=u20090.18, Pu2009=u20090.04).nnnCONCLUSIONSnThe level of knowledge of obstructive sleep apnea among medical students at the Nigerian university in our study was not optimal. This study demonstrates a need to formally incorporate evaluation of sleep disorders into the undergraduate medical curriculum with the clear objective of enabling recognition of clinical features of common sleep disorders such as sleep apnea.

Prospective assessment of the risk of obstructive sleep apnea in patients attending a tertiary health facility in Sub-Saharan Africa

Introduction The impact of Obstructive sleep apnea (OSA) in worsening outcomes is profound, especially in the presence of comorbid conditions. This study aimed to describe the proportion of patients at a high risk of OSA in our practice setting. Methods The STOP BANG questionnaire and the Epworth Sleepiness scale were used to assess for OSA risk and excessive daytime sleepiness respectively. Hospitalized patients and out-patients were recruited. Intergroup differences in continuous variables were compared using the analysis of variance. The proportion of patients with high risk of OSA and excessive daytime sleepiness was presented as frequencies and group differences compared with the Pearson χ2 test. Independent risk predictors for OSA were assessed in multivariate logistic regression analysis. Results A total of 1100 patients (53.4% females) participated in the study. Three hundred and ninety nine (36.3%) had a high risk of OSA, and 268 (24.4%) had excessive daytime sleepiness. Of the participants with high OSA risk, 138 (34.6%) had excessive daytime sleepiness compared to 130 (18.5%) of those with low OSA risk (p). Conclusion A significant proportion of patients attending our tertiary care center are at high risk of OSA.

Current Understanding of Psychosis in Parkinson’s Disease

Psychosis in Parkinson’s disease (PD) is one of the greatest determinants of nursing home placement and caregiver stress. Traditionally associated with medications with dopaminergic effect, it has now been linked to other medications and other stressors e.g. systemic illnesses. The development of hallucinations in a PD patient can herald the onset of dementia and usually predicts increased mortality risk. Medication reduction in PD psychosis usually reduces the symptoms; however, this comes at the cost of worsening motor function. If gradually decreasing the patient’s medications does not resolve the psychosis, the treatment of choice is an atypical antipychotic. Though only clozapine has level A recommendation for this indication, other atypicals like quetiapine continue to get used for this purpose on account of the logistics involved with clozapine use. Cholinesterase inhibitors are also increasingly being used for PD psychosis on account of the association with dementia. The treatment of PD psychosis is an unmet need in PD management and search for suitable agents constitutes an active area of research in PD.

Is it time for flexibility in botulinum inter-injection intervals?

Based largely on old retrospective reports, the recommendation of injecting BoNT as infrequently as possible, with the lowest possible dose, was formed. While BoNT is inherently immunogenic, with improved production, most patients no longer develop immune resistance and poor response to BoNT is often due to other factors. In a randomized controlled trial (RCT) using abobotulinumtoxinA for cervical dystonia (CD) by the German Dystonia Study Group, half of the patients treated with 250 and 500 U, and 39% in the 1000 U group required retreatment after 8 weeks. In a RCT comparing onabotulinumtoxinA and incobotulinumtoxinA for CD by Benecke et al., waning of effect was noted in 70 days for both toxins. Finally, two long-term prospective trials employing flexible intervals, with reinjections based on patients request, have been performed using incobotulinumtoxinA. In the CD study, 22.5% were re-injected in <10 weeks and 24.6% between 10 and 12 weeks. In the blepharospasm study, the median injection interval was 6-10 weeks for 23.7% and 10-12 weeks for 32.3%) While long-term studies utilizing flexible/shortened intervals, with vigilance over immunogenicity are needed, the majority of current evidence no longer support the very stringent adherence to strict 90-day BoNT injection intervals.

A C omputerized Co gnitive behavioral therapy R andomized, Controlle d , pilot trial for insomnia in P arkinson D isease ( ACCORD-PD )

BackgroundParkinson disease (PD) is associated with a high prevalence of insomnia, affecting up to 88% of patients. Pharmacotherapy studies in the literature addressing insomnia in PD reveal disappointing and inconsistent results. Cognitive behavioral therapy (CBT) is a novel treatment option with durable effects shown in primary insomnia. However, the lack of accessibility and expense can be limiting. For these reasons, computerized CBT for insomnia (CCBT-I) has been developed. The CCBT-I program is a 6-week web-based course consisting of daily “lessons” providing learnable skills and appropriate recommendations to help patients improve their sleep habits and patterns.MethodsWe conducted a single-center, pilot, randomized controlled trial comparing CCBT-I versus standardized sleep hygiene instructions to treat insomnia in PD. Twenty-eight subjects with PD experiencing insomnia, with a scorexa0>xa011 on the Insomnia Severity Index (ISI) were recruited. Based on a 6-point improvement in ISI in treatment group when compared to controls and an alphaxa0=xa00.05 and beta of 0.1 (powerxa0=xa090%) a sample size of 11 patients (on active treatment) were required to detect this treatment effect using a dependent sample t-test.ResultsIn total, 8/14 (57%) subjects randomized to CCBT-I versus 13/14 (93%) subjects randomized to standard education completed the study. Among completers, the improvement in ISI scores was greater with CCBT-I as compared to standard education (−7.9 vs −3.5; pxa0=xa00.03). However, in an intention-to-treat analysis, where all enrolled subjects were included, the change in ISI between groups was not significant (−.4.5 vs −3.3; pxa0=xa00.48), likely due to the high dropout rate in the CCBT-I group (43%).ConclusionThis pilot study suggests that CCBT-I can be an effective treatment option for PD patients with insomnia when the course is thoroughly completed. High drop-out rate in our study shows that although effective, it may not be a generalizable option; however, larger studies are needed for further evaluation.