Omer Faruk Kokoglu
Dicle University
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Annals of The Royal College of Surgeons of England | 2006
Mehmet Faruk Geyik; Mustafa Aldemir; Salih Hosoglu; Celal Ayaz; Selda Satilmis; Hüseyin Büyükbayram; Omer Faruk Kokoglu
INTRODUCTION The aim of this study was to investigate the effect of Saccharomyces boulardii treatment on preventing bacterial translocation in an obstructive jaundice animal model. MATERIALS AND METHODS Sixty adult rats were divided into five groups: group 1 - the sham-operated group; group 2 - the common bile duct ligation group; group 3 - the S. boulardii group; group 4 - the ampicillin-sulbaktam group; and group 5 - the S. boulardii plus ampicillin-sulbaktam group. The saline, antibiotics and S. boulardii were given, respectively, for a 7-day period as a single dose per day via temporary orogastric intubation. Seven days following the obstructive jaundice, the animal had laparatomy under sterile conditions. Segments of ileum were removed for histopathological examination. Blood, liver, spleen and mesenteric lymph nodes were taken for microbiological culture. RESULTS Bacterial translocation rates were 0% in the sham-operated group, 83% in group 2, 42% in group 3, 42% in group 4 and 33% in group 5. Bacterial translocation significantly increased in group 2 compared to groups 3, 4 and 5 (P = 0.001). The bacterial counts (CFU/g) of group 2 were significantly higher than those of groups 3, 4 and 5 (P = 0.001). Histopathological examination of ileum specimens revealed a significant decrease in the heights of villi in groups 2-5 compared to the sham-operated group (P = 0.001). The mean villus height in groups 3 and 5 was significantly higher than that of group 4 (P = 0.001). CONCLUSIONS S. boulardii was found to be effective in the successful control of translocation and improvement of intestinal barrier function.
Irish Journal of Medical Science | 1997
Salih Hosoglu; Celal Ayaz; Mehmet Faruk Geyik; Omer Faruk Kokoglu; A. Özen
A retrospective study was conducted to examine the laboratory, clinical features and outcome of 206 adult acute bacterial meningitis patients (218 episodes) during the years 1985–1996. Pneumonia (8.7 per cent), head trauma (7.8 per cent) and chronic otitis media (6.0 per cent) were identified as the main predisposing factors for acute bacterial meningitis. Aetiology was described only in 61 episodes (28.0 per cent). Streptococcus pneumonia was the most commonly identified pathogen overall, causing 33 of the 218 episodes (15.2 per cent). Antibiotic treatment before admission was given to 48.4 per cent of patients. On admission, the following symptoms of meningitis were predominant: 83 per cent had neck stiffness, 81 per cent had a headache and 73 per cent had fever. Case fatality rate was 27.1 per cent (59 patients). The important factors in mortality were as follows: old age, a long duration of symptoms before admission, a lack of neck stiffness, obtunded mental state on admission, low glucose levels in first CSF, low CSF/blood glucose ratio, and abnormality in computerised tomography scanning.
Pediatrics International | 2003
Mehmet Faruk Geyik; Bunyamin Dikici; Omer Faruk Kokoglu; Mehmet Bosnak; Mustafa Kemal Celen; Salih Hosoglu; Celal Ayaz
Abstract Objective : This study was undertaken to investigate the usefulness of spiramycin in treatment for brucellosis in an animal model.
Medical Principles and Practice | 2015
Selma Güler; Fulsen Bozkus; Mehmet Fatih Inci; Omer Faruk Kokoglu; Hasan Ucmak; Sevinc Ozden; Murvet Yuksel
Objective: It was the aim of this study to evaluate the demographic factors and clinical features of extrapulmonary tuberculosis (EPTB) compared to those of pulmonary tuberculosis (PTB) among adult immunocompetent patients. Subjects and Methods: A total of 427 patients with clinically, radiologically and histopathologically confirmed TB were enrolled in the study, in our clinic at a tertiary care hospital in Turkey, during a 5-year period (2007-2012). Patient data were obtained retrospectively. Among the 427 patients, 55 patients with both PTB and EPTB and who were using steroids or had taken immunosuppressive drugs were excluded from the study. Results: Of the 372 patients, 227 (61%) were males and 168 (45.2%) had EPTB; 204 (54.8%) patients had PTB. The most frequent sites of EPTB were the lymph nodes (n = 45, 12.1%), pleura (n = 40, 10.7%) and brain (n = 7, 1.8%). The most common symptoms were cough (n = 174, 46.7%), night sweats (n = 127, 34.1%) and fever (n = 123, 33%). Compared to EPTB patients, PTB patients were less likely to have received Bacillus Calmette-Guérin vaccination (odds ratio 0.41, 95% confidence interval 0.2-0.63; p < 0.001). Eighty-one (48.2%) of the EPTB and 146 (71.6%) of the PTB patients were males. Pulmonary involvement was more common among men (n = 146, 71.6%) than among women (n = 58, 28.2%; p = 0.000). Conclusion: There was a high incidence of EPTB in our study. Early diagnosis of EPTB is crucial for treatment, and atypical presentations of TB should be kept in mind for immunocompetent patients living in endemic areas. Females especially should be investigated for EPTB.
Case Reports | 2013
Selma Güler; Omer Faruk Kokoglu; Hasan Ucmak; Fuat Ozkan
A 24-year-old woman was admitted to our hospital with high fever and poor general status developing 7 days after emergent caesarean section was performed because of the premature rupture of the membranes. She was admitted to the intensive care unit with a diagnosis of sepsis. Her history revealed one abortus and one stillbirth and no endometriosis. She was dehydrated, with shivering, tachycardia and hypotension. Her alanine transaminase, aspartate aminotransferase, bilirubin, blood urea nitrogen and creatine levels were mildly elevated. Teicoplanin and imipenem …
Yonsei Medical Journal | 2002
Mehmet Faruk Geyik; Omer Faruk Kokoglu; Salih Hosoglu; Celal Ayaz
Renal Failure | 2008
Hasan Ucmak; Omer Faruk Kokoglu; Salih Hosoglu; Ekrem Dogan; Hayriye Sayarlioglu; Nuretdin Kuzhan; Ismet Onder Isik
Balkan Medical Journal | 2012
Omer Faruk Kokoglu; Hasan Ucmak; Ergul Belge Kurutas; Nurettin Kuzhan; Remzi Toprak; Ali Cetinkaya; Bulent Kantarceken; Filiz Atalay
Archive | 2012
Hasan Ucmak; Omer Faruk Kokoglu; Ekrem Kireçci; Yusuf Yıldırım; Oğuz Oğuzhan
Clinical Microbiology and Infection | 1997
Salih Hopglu; Celai Ayaz; Mehmet Faruk Geyik; Yusuf Yagmur; Omer Faruk Kokoglu