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Dive into the research topics where Oren Yehezkel is active.

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Featured researches published by Oren Yehezkel.


Scientific Reports | 2012

Training the brain to overcome the effect of aging on the human eye

Uri Polat; Clifton M. Schor; Jianliang Tong; Ativ Zomet; Maria Lev; Oren Yehezkel; Anna Sterkin; Dennis M. Levi

Presbyopia, from the Greek for aging eye, is, like death and taxes, inevitable. Presbyopia causes near vision to degrade with age, affecting virtually everyone over the age of 50. Presbyopia has multiple negative effects on the quality of vision and the quality of life, due to limitations on daily activities – in particular, reading. In addition presbyopia results in reduced near visual acuity, reduced contrast sensitivity, and slower processing speed. Currently available solutions, such as optical corrections, are not ideal for all daily activities. Here we show that perceptual learning (repeated practice on a demanding visual task) results in improved visual performance in presbyopes, enabling them to overcome and/or delay some of the disabilities imposed by the aging eye. This improvement was achieved without changing the optical characteristics of the eye. The results suggest that the aging brain retains enough plasticity to overcome the natural biological deterioration with age.


Vision Research | 2010

Learning to adapt: Dynamics of readaptation to geometrical distortions

Oren Yehezkel; Dov Sagi; Anna Sterkin; Michael Belkin; Uri Polat

The visual system can adapt to optical blur, whereby the adapted image is perceived as sharp. Here we show that adaptation reduces blur-induced biases in shape perception, with repeated adaptations (perceptual learning), leading to unbiased perception upon re-exposure to blur. Observers wore a cylindrical lens of +1.00 D on one eye, thus simulating monocular astigmatism. The other eye was either masked with a translucent blurred lens (monocular) or unmasked (dichoptic). Adaptation was tested in several repeated sessions with a proximity-grouping task, using horizontally or vertically arranged dot-arrays, without feedback, before, after, and throughout the adaptation period. A robust bias in global-orientation judgment was observed with the lens, in accordance with the blur axes. After the observer wore the lens for 2 h, there was no significant change in the bias, but after 4 h, the monocular condition, but not the dichoptic, resulted in reduced bias. The adaptation effect of the monocular 4-h adaptation was preserved, and even improved, when the lens was re-applied the next day, indicating learning. After-effects were observed under all experimental conditions except for the 4-h monocular condition, where learning took place. We suggest that, with long experience, adaptation is transferred to a long-term memory that can be instantly engaged when blur is re-applied, or disengaged when blur is removed, thus leaving no after-effects. The comparison between the monocular and dichoptic conditions indicates a binocular cortical site of plasticity.


Advances in Cognitive Psychology | 2007

Spatio-temporal low-level neural networks account for visual masking

Uri Polat; Anna Sterkin; Oren Yehezkel

T emporal masking is a paradigm that is widely used to study visual information processing. When a mask is presented, typically within less than 100 msec before or after the target, the response to the target is reduced. The results of our psychophysical and visual evoked potential (VEP) experiments show that the masking effect critically depends on a combination of several factors: (1) the processing time of the target, (2) the order of presentation of the target and the mask, and (3) the spatial arrangement of the target and the mask. Thus, the masking effect depends on the spatial-temporal combination of these factors. Suppression was observed when the mask was positioned within a spatial range that was found to evoke inhibition, and when the temporal separation between the target and the mask was short. In contrast, lateral facilitation was observed when the mask was presented at a spatial separation that did not evoke inhibition from the target’s vicinity and with a temporal sequence that preceded the target, or when it was presented simultaneously with it, but not when the target preceded the mask. We propose that masking effects, either suppression or facilitation, reflect integration into the spatial and the temporal domains of the feedforward response to the target and the lateral inputs evoked by the mask (excitatory and/or inhibitory). Because the excitation evoked by the mask develops and propagates slowly from the mask’s location to the target’s location, it lags behind the response to the target. On the other hand, inhibition that is produced in the vicinity of the target evolves more rapidly and follows the onset and offset of the stimulus more closely. Thus, lateral excitation that overcomes the inhibition may facilitate the grouping of local elements into a global percept by increasing the survivability of the object and its accessibility for perceptual awareness.


Optics Express | 2007

Thin spectacles for myopia, presbyopia and astigmatism insensitive vision

Zeev Zalevsky; Shai Ben Yaish; Oren Yehezkel; Michael Belkin

The aim of the presented research was to develop special spectacles capable of solving common ophthalmic problems as myopia, presbyopia and regular/irregular astigmatism. The method included adapting special all-optical extended depth of focus concept, taken from the field of digital imaging, to ophthalmology, and by that providing the required vision solutions. Special thin mask containing annular like replicated structure (thickness of the structure is less than one micron) was designed and proven to provide extended depth of focus. In this paper we present several experimental results as well as trials with volunteers. The testing included measuring the visual acuity under different illumination conditions (pupil size varied from 2 up to 4mm), as well as stereoscopy, color integrity, field of view and contrast. The results demonstrate improvements of up to 3 Diopters (for presbyopic that require the bifocal or the progressive lens solutions) for pupil sizes of 2-4mm. The approach has demonstrated improvement of more than 2 Diopters for regular as well as irregular astigmatism. The main advantage of the developed optical element is that it is very thin (less than few microns) and has low price, it has high energetic throughput and low chromatic aberrations and it operates over the full field of view while providing continuously focused image (in contrast to bifocal lenses having only 2 focused regions). The element also provides a solution for regular as well as irregular astigmatism that currently has no available treatment.


Scientific Reports | 2015

Uncovering foveal crowding

Maria Lev; Oren Yehezkel; Uri Polat

Visual crowding, as context modulation, reduce the ability to recognize objects in clutter, sets a fundamental limit on visual perception and object recognition. Its considered that crowding does not exist in the fovea and extensive efforts explored crowding in the periphery revealed various models that consider several aspects of spatial processing. Studies showed that spatial and temporal crowding are correlated, suggesting a tradeoff between spatial and temporal processing of crowding. We hypothesized that limiting stimulus availability should decrease object recognition in clutter. Here we show, for the first time, that robust contour interactions exist in the fovea for much larger target-flanker spacing than reported previously: participants overcome crowded conditions for long presentations times but exhibit contour interaction effects for short presentation times. Thus, by enabling enough processing time in the fovea, contour interactions can be overcome, enabling object recognition. Our results suggest that contemporary models of context modulation should include both time and spatial processing.


Optics Letters | 2009

Extended depth of focus contact lenses for presbyopia

Alex Zlotnik; Shai Ben Yaish; Oren Yehezkel; Karen Lahav-Yacouel; Michael Belkin; Zeev Zalevsky

The purpose of this Letter is to design, develop, fabricate, and test in clinical trials a new (to our knowledge) type of contact lenses that provides simultaneous near and distance focused vision for presbyopic subjects, including those with up to 2.00 diopters (D) of regular/irregular astigmatism, as an alternative to multifocal contact lenses. The purpose is obtained by generating an optical pattern on the front surface of contact lenses, capable of extending the depth of focus of lenses by 3.00 D with high visual contrast. The pattern was fabricated on top of contact lenses and tested by the use of an eye simulation as well as in clinical trials. Use of the extended depth of focus contact lens enabled patients to achieve good visual acuity and contrast sensitivity for both distance and near vision without compromising the energy distribution or the visual fields.


Vision Research | 2009

Backward masking suppresses collinear facilitation in the visual cortex.

Anna Sterkin; Oren Yehezkel; Yoram Bonneh; Antony Norcia; Uri Polat

Perceptual facilitation in detecting low-contrast Gabor patches (GPs) is induced by collinearly oriented high-contrast flankers. Our recent Visual Evoked Potentials (VEPs) study provided new physiological evidence for these collinear interactions, reflected by nonlinear modulation of multiple waveform components and frequencies [Sterkin, A., Yehezkel, O., Bonneh, Y. S., Norcia, A., & Polat, U. (2008). Multi-component correlate for lateral collinear interactions in the human visual cortex. Vision Research, 48(15), 1641-1647]. Here we used VEPs to study the temporal structure of this process. Low-contrast, foveal target GP (T) was simultaneously flanked by two collinear high-contrast GPs with a spatial separation that induces facilitation of T (lateral masking, LM). Another mask, identical to LM, was presented at different time-intervals (ISIs) after LM (backward masking, BM-on-LM). The responses were compared to separate waveforms evoked by T-alone and mask-alone at different ISIs. BM canceled the physiological markers of facilitation at an ISI of 50 ms, in agreement with earlier psychophysical findings, whereas no BM effect on T-alone was observed. This ISI coincides with the active time-window of lateral interactions, confirming our working model. The waveform amplitude of the negative N1 peak of LM was modulated toward the linear prediction of no interactions and the spectrum was shifted toward suppression, with no evidence of facilitation. Moreover, the P1 peak amplitude of BM was decreased at the same ISI, indicating that there is a mutual interference in cortical representation of both events. Waveform subtraction between BM-on-LM and LM suggests a mechanism of extended persistence of the target representation underlying facilitation in LM. We suggest an explanation for the role of improved detection of collinear stimuli in grouping of contours.


Developmental Science | 2015

Training-induced recovery of low-level vision followed by mid-level perceptual improvements in developmental object and face agnosia.

Maria Lev; Sharon Gilaie-Dotan; Dana Gotthilf-Nezri; Oren Yehezkel; Joseph L. Brooks; Anat Perry; Shlomo Bentin; Yoram Bonneh; Uri Polat

Long-term deprivation of normal visual inputs can cause perceptual impairments at various levels of visual function, from basic visual acuity deficits, through mid-level deficits such as contour integration and motion coherence, to high-level face and object agnosia. Yet it is unclear whether training during adulthood, at a post-developmental stage of the adult visual system, can overcome such developmental impairments. Here, we visually trained LG, a developmental object and face agnosic individual. Prior to training, at the age of 20, LGs basic and mid-level visual functions such as visual acuity, crowding effects, and contour integration were underdeveloped relative to normal adult vision, corresponding to or poorer than those of 5–6 year olds (Gilaie-Dotan, Perry, Bonneh, Malach & Bentin, 2009). Intensive visual training, based on lateral interactions, was applied for a period of 9 months. LGs directly trained but also untrained visual functions such as visual acuity, crowding, binocular stereopsis and also mid-level contour integration improved significantly and reached near-age-level performance, with long-term (over 4 years) persistence. Moreover, mid-level functions that were tested post-training were found to be normal in LG. Some possible subtle improvement was observed in LGs higher-order visual functions such as object recognition and part integration, while LGs face perception skills have not improved thus far. These results suggest that corrective training at a post-developmental stage, even in the adult visual system, can prove effective, and its enduring effects are the basis for a revival of a developmental cascade that can lead to reduced perceptual impairments.


Journal of Refractive Surgery | 2010

Intraocular omni-focal lens with increased tolerance to decentration and astigmatism.

Shai Ben Yaish; Alex Zlotnik; Ido Raveh; Oren Yehezkel; Michael Belkin; Zeev Zalevsky

PURPOSE To measure the optical performance of an extended depth of focus (EDOF) intraocular lens (IOL), which provides an imaging solution for near, intermediate, and distance ranges, and to compare its optical performance to available bifocal IOLs with various extents of decentration and astigmatism aberrations. METHODS A special profile that performs interference principle-based focal extension is engraved on the top of a monofocal rigid IOL. An optical bench based on the L&B eye model was used to test the performance in comparison with the bifocal AcrySof ReSTOR SA60D3 lens (Alcon Laboratories Inc). RESULTS The imaging performances at near, intermediate, and distance ranges were mapped. Different decentration parameters and amount of astigmatism aberration were tested. In numerical simulations and the experimental bench, the EDOF IOL was demonstrated to have good visual acuity in near, intermediate, and distance ranges as well as reduced sensitivity to decentration of up to 0.75 mm and the capability of correcting astigmatism aberrations of up to 1.00 diopter. CONCLUSIONS Extended depth of focus technology is capable of providing clear and focused vision at near, intermediate, and distance ranges. Its high quality imaging is obtained under large decentration conditions and residual astigmatism. This capability broadens the potential use of the technology beyond its application as a simultaneous multifocal lens.


Vision Research | 2008

Multi-component correlate for lateral collinear interactions in the human visual cortex

Anna Sterkin; Oren Yehezkel; Yoram Bonneh; Anthony M. Norcia; Uri Polat

Perceptual facilitation, a decrease in detection threshold for low-contrast Gabor patches (GPs) occurs when the GP is flanked by collinearly oriented high-contrast patches. There is earlier evidence suggesting a spatial architecture of excitatory and inhibitory interactions. Here we used Visual Evoked Potentials (VEPs) to study the temporal structure of this process. We measured VEPs elicited by a foveal near-threshold target GP presented in isolation (T), T in the presence of two flanking collinear high-contrast GPs (lateral masking, LM), or the flankers alone (F). Stimuli were presented for 50 ms every 1000 ms. The choice of the set parameters elicited behavioral facilitation of T detection. Significant modulation of peak amplitudes in LM compared with linearly summed waveforms elicited by T and F was found for five alternating polarity components, ranging from 65 to 290 ms after stimulus onset. In the frequency domain, suppression at lower frequencies (up to 0.8 log units) was followed by facilitation at higher frequencies (4-6 Hz, up to 0.8 log units). Although no differences in the latencies were found, lateral interactions were reflected by non-linear waveform modulation of multiple components and frequencies, including components as early as 65-75 ms. Spectrum analysis suggests that both suppression and facilitation may be found for the same configuration of stimuli, simultaneously, distributed at different temporal frequencies and/or sources. The physiological correlates of lateral interactions may thus originate at multiple sources, only some of which are explicitly facilitatory. The final perceptual outcome of this complex spatio-temporal representation is determined by combining sensory and cognitive factors.

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Michael Belkin

Brigham and Women's Hospital

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Dov Sagi

Weizmann Institute of Science

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