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Featured researches published by Osamu Asano.


Tetrahedron Letters | 1986

Synthetic studies on teleocidin I. Regioselective introduction of 4-amino and 7-acyl groups on indole derivative

Shin-ichi Nakatsuka; Toshiya Masuda; Osamu Asano; Tomohiro Teramae; Toshio Goto

Nitration of indole-3-carboxylic esters, 3 and 9, afforded 4-nitro derivatives, 4 and 10. 10 was regioselectively derived to 15, which contains substituents at 4- and 7-positions of indole nucleus similarly to teleocidins.


Tetrahedron Letters | 1983

Total synthesis of bicyclomycin

Shin-ichi Nakatsuka; Kozi Yamada; Kumi Yoshida; Osamu Asano; Yoshihiro Murakami; Toshio Goto

Abstract Total synthesis of (±)bicyclomycin was achieved in 19 steps starting from diketopyperazine.


Heterocycles | 1987

Synthetic studies on teleocidin. III: Regioselective introduction of nitro group at 4-position of substituted indole derivatives

Shin-ichi Nakatsuka; Toshiya Masuda; Kazuo Ueda; Osamu Asano; Toshio Goto

Etude de la nitration des composes suivants: dihydro-5,6 dimethyl-6,6- et dihydro-5,6 isopropyl-7 pyrrolo [3,2,1-ij] quinoleinecarboxylates-1 de methyle, dimethyl 5a,8 hexahydro-4,5,5a,6,7,8 isopropyl-8 benzo [de] pyrrolo [3,2,1-ij] quinoleinecarboxylate-1 de methyle et dimethyl-6,9 isopropyl-6 tetrahydro-6,7,8,9 vinyl-9 benzo [g] indolecarboxylate-3 de methyle


Heterocycles | 1986

Methyl Group at 1-Position of Stabilized Indoles as a Protective Group

Shin-ichi Nakatsuka; Osamu Asano; Toshio Goto


Heterocycles | 1987

Efficient Synthesis of Indoloquinone Derivations by Several Oxidative Derivatib\ves of 6-Methylindole

Shin-ichi Nakatsuka; Kazuo Ueda; Osamu Asano; Toshio Goto


Heterocycles | 1987

Introduction of a Hydroxy Group onto 5- and 6-Position of Indole Nucleus by Friedel-Crafts Acylation and Subsequent Baeyer-Villiger Oxideation

Shin-ichi Nakatsuka; Osamu Asano; Kazuo Ueda; Toshio Goto


Heterocycles | 1987

Efficient synthesis of indoloquinone derivative by several oxidative derivations of 6-methylindole

Shin-ichi Nakatsuka; Kazuo Ueda; Osamu Asano; Toshio Goto


Heterocycles | 1987

Synthetic studies on mitomycin. I: Synthesis of 7-methoxymitosene from 6-methylindole by selective oxidation of benzene part

Osamu Asano; Shin-ichi Nakatsuka; Toshio Goto


Heterocycles | 1987

Synthesis of 1,2-aziridino-2,3-dihydro-1H-pyrrolo[1,2-a]indole derivatives similar to the activated forms of mitomycin

Shin-ichi Nakatsuka; Osamu Asano; Toshio Goto


Heterocycles | 1986

Regiospecific cyclization of 3-carbomethoxyindole-1-propanoic acid onto 7-position of the indole nucleus

Shin-ichi Nakatsuka; Osamu Asano; Toshio Goto

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