Osamu Edamitsu

A Case of Liver Cirrhosis with a Hyperplastic Nodular Lesion

A hyperplastic nodular lesion resembling focal nodular hyperplasia (FNH) was found in the cirrhotic liver of a 50‐year‐old male patient. A nodule was detected by ultrasonography and hepatic angiography conducted as part of a routine follow‐up study for chronic liver disease, and was excised under a diagnosis of suspected hepatocellular carcinoma. Grossly, central stellate scar‐like septa subdividing the nodule ware noted. These fibrous septa contained many small arteries and veins, as well as bile ducts. The parenchyma of the nodule also contained many small arteries. Although these findings were similar to those seen in typical FNH, the present lesion was different in that it was encapsulated, occurred against a background of liver cirrhosis, lacked hepatocyte hyperplasia and showed hemosiderin deposition.

Eosinophilic Granuloma of Lymph Node

Eosinophilic granuloma confined to the lymph node of a 25‐year‐old Japanese woman is reported. She presented with a low‐grade fever and pain in the left cervical region. A finger‐tip‐sized cervical lymph node was excised for histological study. Microscopically, the normal architecture of the lymph node was distorted, and histiocytoid cells had proliferated mainly in the sinus. Numerous eosinophils and an appreciable number of large multinucleated cells were also observed. Ultrastructurally, Birbeck granules were found in the cytoplasm of the histiocytoid cells. Immunohistochemically, the proliferating cells and multinucleated cells were found to be positive for S 100 protein but negative for lysozyme in the cytoplasm. The patient has been well without recurrence for 10 months after the lymph node biopsy. Acta Pathol Jpn 40: 851‐855, 1990.