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Publication
Featured researches published by Osamu Numata.
Journal of Cardiovascular Electrophysiology | 2000
Hiroshi Suzuki; Katsumi Torigoe; Osamu Numata; Satoshi Yazaki
Infant with Brugada Syndrome. We report a 6‐nionth‐old Japanese infant with a malignant form of Brugada syndrome, who had frequent episodes of ventricular fibriitation (VF) and nonsustained polymorphic ventricular tachycardia (VT). To the best of our knowledge, this infant is the youngest patient reported to have Brugada syndrome. Continuous infusion of a β‐adrenergic agonist and intravenous injection of a parasympathetic antagonist suppressed the electrical storm of polymorphic VT and VF. Combined oral administration of a β1‐adrenergic agonist, a parasympathetic antagonist, and quinidine has successfully suppressed recurrences of VT or VF for 6 months, and the combination may have the potential to decrease the incidence of VT or VF as an adjunctive therapy with prophylactic placement of an implantable cardioverter defibrillator.
Pediatrics International | 2000
Katsumi Torigoe; Satoshi Hasegawa; Osamu Numata; Satoshi Yazaki; Masamichi Matsunaga; Naoki Boku; Makoto Hiura; Haruyoshi Ino
Abstract Background : Emission from rice straw burning (ERSB) is observed everywhere after harvest of rice in Niigata Prefecture every year. Pediatricians and many guardians in this district have had the impression that ERSB may induce asthma attack. Recent studies have suggested that particulate air pollution plays a role in the exacerbation of asthma. The authors investigated relationship of ERSB to asthma attack in children.
Pediatrics International | 2001
Katsumi Torigoe; Osamu Numata; Youhei Ogawa; Utako Kaneko; Touhei Usuda; Masaru Imamura; Kazuo Takeuchi; Hiroshi Suzuki; Hikosato Endo
Abstract Background : Children with orthostatic dysregulation (OD) appear to have hypodynamia, as well as the symptoms described in the OD criteira. Hypodynamia, which is greatly influenced by motivation, volition and concentration, is unexceptionally recognized in their everyday life. It has been suggested that the symptoms and hypodynamia aggravate considerably the quality of life (QOL) of children with OD. The purpose of this study was to distinguish the characteristics of contingent negative variation (CNV) and post imperative negative variation, which may reflect the level of attention and motivation in children with OD.
Pediatrics International | 2003
Hajime Yamazaki; Katsumi Torigoe; Osamu Numata; Sakiko Nagai; Hisanori Haniu; Asami Uchiyama; Youhei Ogawa; Masaru Imamura; Satoshi Hasegawa
Background : Although elective cesareansections are often performed after the 37th week of gestation withoutany complicating factor that may influence the timing of delivery,there is a possibility that infants born in the 37th week of gestation,especially early in the 37th week of gestation, do not obtain asatisfactory clinical outcome due to premature birth.
Pediatrics International | 1999
Katsumi Torigoe; Osamu Numata; Takashi Sato; Chihaya Imai; Kazuo Takeuchi; Hajime Yamazaki; Hiromitsu Hotta; Naoki Boku; Satoshi Yazaki; Shyoji Sudo; Atsushi Kuwabara; Satoshi Hasegawa; Makoto Hiura; Haruyoshi Ino
Abstract Background: Central catecholamines, particularly dopaminergic and noradrenergic systems, have affected the appetitive behavior in patients with anorexia nervosa (AN). The purpose of this study is to distinguish the characteristics of contingent negative variation (CNV) and postimperative negative variation (PINV), which may reflect the level of catecholamine in children with AN.
Pediatrics International | 1999
Katsumi Torigoe; Osamu Numata; Satoshi Yazaki; Satoshi Hasegawa; Naoki Boku; Makoto Hiura; Haruyoshi Ino; Masamichi Matsunaga
Abstract Background: Abnormal sympathetic skin response (SSR) has been reported in adult patients with diabetic neuropathy. In addition, other studies have revealed abnormal SSR in diabetic patients not having autonomic symptoms and autonomic dysfunctions. These findings have been only obtained from adult patients. There have been few reports on the autonomic functions in diabetic children. Accordingly, it is not clear whether the autonomic neuropathy occurs in diabetic children. The aim of the present study is to clear autonomic function in children with insulin‐dependent diabetes mellitus by SSR.
Pediatrics International | 2012
Touhei Usuda; Takehiro Kobayashi; Seiichi Sakakibara; Akira Kobayashi; Takayuki Kaneko; Masaki Wada; Junya Onozuka; Osamu Numata; Katsumi Torigoe; Hajime Yamazaki; Takashi Sato; Yoshihisa Nagayama; Makoto Uchiyama
Background: The aim of the present study was to evaluate the role of interleukin (IL)‐6‐634 polymorphism in neonatal disorders such as bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) in very low‐birthweight (VLBW) infants.
Pediatrics International | 1999
Chihaya Imai; Hajime Yamazaki; Yasuki Tanaka; Masamichi Matsunaga; Osamu Numata; Katsumi Torigoe
Abstract Background: It is a matter of concern whether serum eosinophil cationic protein (ECP) can be considered as a disease marker in children with acute asthma being treated without corticosteroids.
Pediatrics International | 2016
Jun Nirei; Yuta Aizawa; Minoru Okazaki; Akira Kobayashi; Junya Onozuka; Osamu Numata; Tomohiro Oishi; Akihiko Saitoh
Four infants born prematurely presented with multiple apnea episodes caused by human parechovirus type 3 (HPeV3) infection. All patients required oxygen supplementation, and one patient required mechanical ventilation. HPeV3 infection might be included in the differential diagnosis of apnea in neonates and young infants, especially those born prematurely.
Pediatrics International | 2004
Hajime Yamazaki; Katsumi Torigoe; Osamu Numata; Hisanori Haniu; Asami Uchiyama; Yohei Ogawa; Utako Kaneko; Masaru Imamura; Satoshi Hasegawa
Mitochondrial fatty acid β -oxidation provides the primary source of energy for the heart and other high energyrequiring tissue. Mitochondrial trifunctional protein (MTP), an enzyme involved in fatty acid β -oxidation with specificity to the long carbon chain, is a multienzyme complex composed of four molecules of the α -subunit containing 3-hydroxyacyl-CoA dehydrogenase, the enoyl-CoA hydratase domains and four molecules of the β -subunit containing the 3-ketoacyl-CoA thiolase domain. MTP deficiency is characterized by deficiency of all three enzyme activities. 1 Long chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency in man was first described in 1989. 2 Recently, it was found that LCHAD deficiency is caused by an abnormality in MTP. 3