Osamu Ogino

Development of a Synthetic Drug Information Database for Cardiovascular Agents

We developed useful databases of cardiovascular agents to support the drug information service for patients, medical doctors and nurses. This system consists of six databases, including : 1) various information data about drug efficacies, cautions, warnings and contraindications, side effects, prudent medication, drug interactions, pharmacokinetics for 148 medicines, 2) relief information regarding disease state for cardiomyopathy and heart failure, 3) the search method to identify corresponding drugs from side effect data, 4) the mechanisms and the grade of drug interaction, 5) international mega trials regarding cardiovascular drugs, 6) connection with the information leaflets for patients already developed in our hospital. We are able to refer to information data by connecting these databases with each other on a notebook PC and thereby quickly provide accurate information.

pH Prediction in Multiple Admixture Based on the Acid-Base Eqilibrium Theory.

A method for predicting pH changes in multiple admixtures was designed on the basis of the acid-base equilibrium theory. The pHs of transfusions mixed with the various injections were estimated by solving a general theoretical equation for proton concentrations in the multicomponents-blended aquaous solution obtained using a dichotomy as the algorithm. Eighty-two transfusions and parenteral solution mixture combinations were examined for the efficacy of the predicted equation. As a result, the estimated pH was in good agreement with the measured pH in all examinations, and a good corelation existed between the measured and calculated values of pH. Furthermore, the incompatibility of the parenteral admixture can be easily predicted using the present estimation-program for pH changes without any preliminary pH titration tests. These results suggest that this prediction method will be a useful tool for constructing and handling database incompatibility.