Oscar Gutiérrez

Takayasu arteritis in Colombia.

Takayasu arteritis has been recognized in Colombia just recently, and so far we do not have any report concerning its presentation here. In this first report, some issues related to the presentation of the disease are indicated and compared with those found in the medical literature. No differences were found in age and sex. Most of the cases were diagnosed during an inactive phase of the disease with advanced manifestations due to vascular lesion which suggests the existence of some genetic factor influencing such a presentation, or may be the consequence of a delay in diagnosing the disease during initial and active stages due to not suspecting it. Comparing the vessels which are affected among other races and countries, we can find both differences and similarities. With the purpose of discovering the demographic, clinical, angiographic and laboratorial characteristics of Takayasu arteritis in Colombia, the present study was carried out by studying 35 clinical cases in different medical centers of the country.

Evaluación de la Citotoxicidad Inducida por TiO2 modificado Funcionalizado con Folato y Oro sobre Líneas Celulares de HeLa y CHO

espanolEl objetivo de este trabajo fue la determinacion del efecto fotocatalitico de los nanocompuestos TiO2mod-AF y TiO2mod-AF-Au en linea celular de cancer de cuello uterino HeLa y linea celular normal CHO. El oxido de titanio (TiO22), una sustancia con posibles y futuros usos en los tratamientos de diferentes tipos de cancer, es analizado por su posible citotoxicidad al estar expuesto a la luz ultravioleta. Se determino el porcentaje de citotoxicidad de los nanomateriales en presencia y ausencia de luz ultravioleta mediante el kit de deteccion de citotoxicidad. Los resultados mostraron que los nanomateriales bajo los parametros establecidos son toxicos en celulas HeLa, y no toxicos en celulas CHO. El mayor porcentaje de citotoxicidad en celulas HeLa fue 78% que corresponde al efecto del nanomaterial TiO2mod-AF-Au expuesto a 40 min de radiacion ultravioleta. Estos resultados de selectividad hacia celulas cancerigenas abren una posible via para el tratamiento del cancer con menos efectos secundarios sobre la salud humana. EnglishThe main objective of this work was to determine the photocatalytic effect of the TiO2mod-FA and TiO2mod-FA-Au nanomaterials on Hela and CHO line cells. Titanium oxide (TiO2), a substance with possible and future use on the treatment of different cancer types, is analyzed due to its possible cytotoxicity effects when it is exposed to ultraviolet light. The level of cytotoxicity of the nanomaterials in presence and absence of ultraviolet light was determined by the cytotoxicity detection kit. The results showed that the nanomaterials under the established parameters are toxic on Hela cells but non-toxic on CHO cells. The effect of the TiO2mod-FA-Au nanomaterials exposed over 40 minutes to ultraviolet light showed 78% of cytotoxicity on Hela cells, being the highest percentage between the nanomaterials. The selectivity over cancer cells was the main finding that could become a possible path for cancer treatment with lower secondary effects on human health.