Oscar H. Grandas
University of Tennessee Medical Center
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Publication
Featured researches published by Oscar H. Grandas.
Cardiovascular Surgery | 2001
Oscar H. Grandas; Michael J. Costanza; Robert L. Donnell; Tonya T. Reddick; Roger C. Carroll; Scott L. Stevens; Michael B. Freeman; Mitchell H. Goldman
This study evaluated the effect of retroviral transduction on canine microvascular endothelial cell (CMVEC) detachment from fibrin glue coated expanded polytetrafluoroethylene (ePTFE) graft material. CMVEC were isolated from adipose tissue by fluorescent activated cell sorting (FACS). Three treatment groups were evaluated: G-I, transduced CMVEC, selected in antibiotic G418 for 10 days (n=5); G-II, CMVEC selected in G418 and recovered from selection for 4 days (n=5); and G-III, control group of naive CMVEC (n=6). (3)H-thymidine labeled endothelial cells were seeded on fibrin glue coated four-mm diameter PTFE. Grafts were exposed to physiologic shear stresses of 16 dyn/cm(2). Cell detachment was determined by (3)H-thymidine counts in the circuit effluent. beta(1) integrin subunit expression was measured by flow cytometry. After 2 hours of flow exposure, G-I and G-II demonstrated significantly greater cell detachment rates compared with the control seeded grafts. Median peak channel beta(1) integrin subunit value for G-III CMVEC was 2311+/-481.7 vs. 31.5+/-4.51 and 26.3+/-2.0 in the transduced cell groups (p=0.00043). Low beta(1) integrin expression correlated with flow induced high detachment rates of retrovirally-transduced CMVEC.
Journal of Vascular Surgery | 2000
Carlos H. Timaran; Scott L. Stevens; Oscar H. Grandas; Kenneth T. Piercy; Michael B. Freeman; Mitchell H. Goldman
Journal of Vascular Surgery | 2001
Carlos H. Timaran; Scott L. Stevens; Oscar H. Grandas; Michael B. Freeman; Mitchell H. Goldman
Annals of Vascular Surgery | 2006
David C. Cassada; Amy L. Lipscomb; Scott L. Stevens; Michael B. Freeman; Oscar H. Grandas; Mitchell H. Goldman
summer computer simulation conference | 2007
James J. Nutaro; Kara L. Kruse; Richard C. Ward; Elizabeth O'Quinn; Matthew Woerner; Barbara G. Beckerman; Stacy S. Kirkpatrick; Deidra Mountain; Oscar H. Grandas
Journal of Vascular Surgery | 2017
Jonathan S. Cudnik; Michael Best; Stacy S. Kirkpatrick; Michael B. Freeman; Oscar H. Grandas; Deidra J. Mountain
Journal of Vascular Surgery | 2015
Brian M. Freeman; Deidra J. Mountain; Timothy Brock; Stacy S. Kirkpatrick; Joshua D. Arnold; Scott L. Stevens; Mitchell H. Goldman; Michael B. Freeman; Frederick A. Klein; Oscar H. Grandas
Journal of Surgical Research | 2014
Brian M. Freeman; Deidra J. Mountain; Timothy C. Brock; Jason R. Chapman; Stacy S. Kirkpatrick; Joshua D. Arnold; Scott L. Stevens; Mitchell H. Goldman; Michael B. Freeman; Frederick A. Klein; Oscar H. Grandas
Archive | 2012
Deidra J.H. Mountain; Stacy S. Kirkpatrick; Michael B. Freeman; Scott L. Stevens; Mitchell H. Goldman; Oscar H. Grandas
Journal of Surgical Research | 2011
Deidra J. Mountain; Stacy S. Kirkpatrick; David C. Cassada; Scott L. Stevens; Michael B. Freeman; Mitchell H. Goldman; Oscar H. Grandas