Oskar Axelsson

Parahydrogen‐induced polarization in imaging: Subsecond 13C angiography

High nuclear spin polarization of 13C was reached in organic molecules. Enhancements of up to 104, compared to thermal polarization at 1.5 T, were achieved using the parahydrogen‐induced polarization technique in combination with a field cycling method. While parahydrogen has no net polarization, it has a high spin order, which is retained when hydrogen is incorporated into another molecule by a chemical reaction. By subjecting this molecule to a sudden change of the external magnetic field, the spin order is transferred into net polarization. A 13C angiogram of an animal was generated in less than a second. Magn Reson Med 46:1–5, 2001.

The Suzuki Reaction Under Solvent-Free Conditions

Abstract The coupling reaction of diverse arylhalogenids with phenyl-boronic acid under solvent-free conditions has been performed using a palladium catalyst. The order of reactivity was complementary to the normal Suzuki reaction.

Synthesis and biological activity of the neuronal calcium channel blocker 2-amino-1-(2,5-dimethoxyphenyl)-5-trifluoromethyl benzimidazole (NS-649)

Abstract The substituted benzimidazole, NS-649, has been shown to be a blocker of neuronal calcium channels in patch-clamp studies. NS-649 dose-dependently inhibited release of d -aspartate from cerebellar granule neurons. The neuroprotective effect of this compound in in vitro and in vivo models of ischemia was demonstrated.