Osman Şener

Erratum to: Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency

SummaryBackgroundWe aimed herein to investigate the killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with common variable immunodeficiency (CVID), and to reveal their differences from those in healthy population.MethodsIn all, 18 patients who have been diagnosed with CVID and 15 living donors of kidney transplant recipients were enrolled in the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) typing method was used in molecular genetic analysis. The frequencies of the genes in the study groups were statistically compared with each other using chi-square or Fisher exact tests, whichever were appropriate.ResultsAlthough there was no significant difference between both study groups with respect to distribution of KIR and HLA-C2 group genes, HLA-Cw7 allele frequency in patients with CVID was significantly lower than that in healthy population (P = 0.008).ConclusionThis present study results support that HLA-Cw7 allele, an inhibitor of KIR ligand, may play a role in the pathogenesis of CVID.

Adults with common variable immunodeficiency: a singlecenter experience

BACKGROUND/AIM In this study, we aimed to assess the clinical and immunological findings of our patients with common variable immunodeficiency (CVID). MATERIALS AND METHODS We analyzed the records of 31 adult patients with CVID (12 females, 19 males). The patients were classified into clinical and immunophenotypic subgroups for statistical comparisons. RESULTS Our patients had some clinical signs in considerable frequencies, such as low body weight (45.2%), urinary tract infections (41.9%), various dermatoses (35.5%), and oral aphthae (32.3%). The histological findings in the biopsy specimens of the gastrointestinal tract (nodular lymphoid hyperplasia, villous atrophy, and lymphocytic infiltrates at mucosa) were significantly associated with splenomegaly, hepatomegaly, or low body weight (P = 0.005, 0.045, and 0.007, respectively). The patients with low CD4/CD8 ratios had lower IgG levels and a lower percentage of CD19+ B cells, but a higher percentage of activated T cells (P = 0.023, 0.011, and 0.028, respectively). CONCLUSION In adults with CVID, there existed some clinical signs at considerable frequencies, but these are not overemphasized in the literature. The CD4/CD8 ratio is an important factor in antibody production and the clinical presentation of CVID. It seems that the adaptive immune system is on alert and subclinical immune activation insidiously continues in patients with CVID.

P06 - Pulmonary functions are affected during pollen season in children with allergic rhinitis

Results Thirty patients (17 male, 56.7%) with a median age of 11.5 (8.7-13.6) years were included. 12 patients (40%) had mild allergic rhinitis, whereas 18 (60%) had moderate-persistent allergic rhinitis interfering with daily activities. There was no significant difference at spirometric parameters including forced vital capacity (FVC), forced expiratory volume at 1 second (FEV1) and FEV1/FVC ratio, which obtained in and out of pollen season. However, the forced expiratory flow between the 25 and 75% of the vital capacity (FEF25-75) (100 (91-96) vs. 91 (83-104)) and peak expiratory flow (PEF) (92 (83-97) vs. 82 (76-94)) values were significantly lower in pollen season when compared with the values obtained out of pollen season. Conclusion Pulmonary functions may be affected in children with pollen-induced allergic rhinitis during pollen season even if they have no history and symptoms of bronchial asthma.