Oswald Burkhard

Excited state dipole moments and polarizabilities of centrosymmetric and dimeric molecules. I. Model study of a bichromophoric molecule

Abstract Refractometric, dielectric and electro-optical absorption measurements are reported for 1-dimethylamino-2,6-dicyano-4-methyl-benzene (I) and 1,4-bis(4′-dimethylamino-3′,5′-dicyanophenyl)bicyclo[2.2.2]octane (II). The evaluation leads to dipole moments and polarizabilities of the ground state as well as the first dipole allowed singlet state. The experimental res excellently substantiate the method of electro-optical absorption measurements in solution. It is shown that the excited dimer wavefunctions of the bichromophoric molecule II localize by solvent induced local site perturbations.

Model Substances for Electro-optical and Dielectric Studies, Part I Synthesis and Structure of 1,4-Bis(4'-dimethylamino-3',5'-dicyanophenyl)bicyclo[2.2.2]octane

A synthesis for a new 1,2,6-donor-acceptor-substituted chromophoric benzene system is given. This chromophore is incorporated in a bicyclo[2.2.2]octane system to build up model compounds for electro-optical and dielectrical studies. Furthermore a preparative convenient route to derivatives of 1,4-bis(diphenyl)bicyclo[2.2.2]octane is worked out. The structures of the new compounds are proven by spectroscopical means.

Is it important to separate leucocytes and platelets before measuring the filterability of red blood cells

legend for Fig 4 was printed under Fig 3 and legend for Fig 5 was printed under Fig 4. If a distinguished investigator like Dr Girolami overlooked the discrepancy between the text and the parameters printed on the ordinates of Figs 3 , 4 and 5 on the one hand and the legends of the Figures on the other, I am afraid that other readers may get confused. Regarding the specific comments and questions raised by Dr Girolami, I think there is little to add since our homozygous cases had only a partially decreased subunit B level which corresponds to what Dr Girolami called type I1 disease and not type I as he erroneously thought. Regarding two other comments raised by Dr Girolami, I have not been aware of a significant contamination of the anti factor XIII-subunit-B antibody (Behringwerke) with an antibody to factor VIII related antigen. I do not feel, however that this could be the cause for an artefact. If there was an additional antibody apart from the anti-subunit-B antibody one would expect to see a double rocket in the electroimmunoassay of normal plasmas, which was not the case in our studies. Furthermore, Dr Girolami concludes his letter by stating that only in heterozygotes related to probands with complete absence of subunit B. an intermediate level of subunit B can be observed. This was not our experience with our ‘type I1 families’. Thus, as shown in our paper, homozygotes as well as heterozygotes had significantly decreased subunit B levels as follows:

The Determination of Molecular Quantities from Measurements on Macroscopic Systems.II. The Determination of Electric Dipole Moments

Abstract Some bulk quantities appropriate for the description of dielectric and refractometric measurements on macroscopic systems are defined and their properties are discussed. Based on three molecular models (Lorentz model, Onsager model in spherical approximation, and in ellipsoidal approximation) model molar quantities are introduced, which depend on intrinsic properties of the molecule, i.e. the electric dipole moment and the polarizability. The relations will be applied for the evaluation of the results of dielectric and refractometric measurements on eight aromatic molecules.