Otto Blome

[Evidence-based evaluation of the effect of Type IV Allergies on the reduction of fitness for work. Survey of occupational skin diseases].

ZusammenfassungBisher fehlen evidenzbasierte Empfehlungen zur Beurteilung der beruflichen Exposition von Typ-IV-Allergene der Standardreihe. Aufgrund publizierter Literatur, epidemiologischer Untersuchungen, arbeitstechnischer Kenntnisse und spezifischer Allergeneigenschaften werden für folgende Typ-IV-Allergene diesbezügliche Empfehlungen vorgestellt: Acrylate/Methacrylate, Epoxidharzsysteme, Dichromat, Kobaltsalze, Nickel, Formaldehyd, (Chlor-)Methylisothiazolone, p-Phenylendiamin, Kolophonium, Thiurame, Mercaptobenzothiazole, Dithiocarbamate, N-Isopropyl-N’-phenyl-p-phenylendia-min, Duftstoffe, Kompositen, Neomycinsulfat. Dadurch wird die Aufklärung und allergologische Beurteilung der Auswirkung von Typ-IV-Sensibilisierungen im Berufsleben entscheidend verbessert.AbstractEvidence-based guidelines about the distribution of type IV allergens of the European standard series in different professions and its occupational relevance are missing. Based on published data, epidemiological investigations, work related knowledge about industrial processes, and allergen specific properties, recommendations are given about the clinical impact in the working environment for the following allergens: Acrylates/Methacrylates, Epoxy resins, Dichromate, Cobalt, Nickel, Formaldehyde, (Chlor-)Methylisothiazolone, p-Phenylendiamine, Colophony, Thiurame, Mercaptobenzothiazole, Dithiocarbamate, N-Isopropyl-N’-phenyl-p-phenylendiamine, Fragrance Mix, Composite Mix, and Neomycinsulfate. These recommendations might improve the clearance rate and allergological evaluation of the occupational relevance of different delayed type sensitizations or allergens.

UV‐induced occupational skin cancer: possibilities of secondary individual prevention in the “Dermatologist's Procedure”

Invasive squamous cell carcinoma (SCC) as a “quasi occupational disease” according to §9 Section 2 of the German Social Code Book (SGB) VII typically develops on chronically UV‐damaged skin from actinic keratoses. After the Medical Scientific Committee of the Federal Ministry of Labor and Social Affairs has confirmed the legal criteria for acknowledging UV‐induced SCC as an occupational disease, it is expected that the condition will be added to the official list of occupational diseases issued by the Federal Government in the near future. The Social Accident Insurance is required by law (§3 Occupational Disease Regulation) to prevent these tumors by “all appropriate means“. There are excellent therapeutic and preventive measures for the management of actinic keratoses to avoid the development of SCC. The “Dermatologists Procedure“ according to §§ 41–43 of the agreement between the Social Accident Insurance and the Federal Medical Association was established in Germany in 1972 to take preventive measures in insured persons with skin lesions possibly developing into an occupational disease, or worsening it, or leading to a recurrence of it This procedure proved to be very successful in the prevention of severe and/or recurring skin diseases forcing a worker to leave his job. On the basis of this agreement, the Social Accident Insurance has the instruments to independently provide preventive measures for the new occupational skin disease SCC induced by natural UV light according to §9 Section 2 of the German Social Code Book (SGB) VII.

Evidenzbasierte Beurteilung der Auswirkung von Typ-IV-Allergien bei der Minderung der Erwerbsfähigkeit

ZusammenfassungBisher fehlen evidenzbasierte Empfehlungen zur Beurteilung der beruflichen Exposition von Typ-IV-Allergene der Standardreihe. Aufgrund publizierter Literatur, epidemiologischer Untersuchungen, arbeitstechnischer Kenntnisse und spezifischer Allergeneigenschaften werden für folgende Typ-IV-Allergene diesbezügliche Empfehlungen vorgestellt: Acrylate/Methacrylate, Epoxidharzsysteme, Dichromat, Kobaltsalze, Nickel, Formaldehyd, (Chlor-)Methylisothiazolone, p-Phenylendiamin, Kolophonium, Thiurame, Mercaptobenzothiazole, Dithiocarbamate, N-Isopropyl-N’-phenyl-p-phenylendia-min, Duftstoffe, Kompositen, Neomycinsulfat. Dadurch wird die Aufklärung und allergologische Beurteilung der Auswirkung von Typ-IV-Sensibilisierungen im Berufsleben entscheidend verbessert.AbstractEvidence-based guidelines about the distribution of type IV allergens of the European standard series in different professions and its occupational relevance are missing. Based on published data, epidemiological investigations, work related knowledge about industrial processes, and allergen specific properties, recommendations are given about the clinical impact in the working environment for the following allergens: Acrylates/Methacrylates, Epoxy resins, Dichromate, Cobalt, Nickel, Formaldehyde, (Chlor-)Methylisothiazolone, p-Phenylendiamine, Colophony, Thiurame, Mercaptobenzothiazole, Dithiocarbamate, N-Isopropyl-N’-phenyl-p-phenylendiamine, Fragrance Mix, Composite Mix, and Neomycinsulfate. These recommendations might improve the clearance rate and allergological evaluation of the occupational relevance of different delayed type sensitizations or allergens.

Occupational syncarcinogenesis in the skin – combined effects of two carcinogens from the German occupational disease list

Though scientifically undisputed, cutaneous syncarcinogenesis is not reflected in German occupational disease (OD) regulations, which tend to be guided by the tenet of monocausality. Recognition of nonmelanoma skin cancer (NMSC) and its precursor lesions as OD requires individual assessment as to whether the requirements pursuant to either OD 5103 (occupational exposure to natural UV radiation) or OD 5102 (occupational exposure to polycyclic aromatic hydrocarbons) are fulfilled.

Arbeitsbedingte Synkanzerogenese an der Haut – Zur kombinatorischen Einwirkung zweier Karzinogene der Berufskrankheiten‐Liste

Die Synkanzerogenese am Hautorgan, wissenschaftlich unstrittig, spiegelt sich im monokausal geleiteten Berufskrankheiten (BK)‐Recht nicht wider. Nichtmelanozytäre Hauttumoren und deren Vorläuferläsionen können nur nach Einzelprüfung der BK‐Nrn. 5103 und 5102 anerkannt werden.

Evidenzbasierte Beurteilung der Auswirkung von Typ-IV-Allergien bei der Minderung der Erwerbsfähigkeit@@@Evidence-based evaluation of the occupational relevance of different delayed type sensitizations or allergens: Begutachtung berufsbedingter Hautkrankheiten@@@Survey of occupational skin diseases

ZusammenfassungBisher fehlen evidenzbasierte Empfehlungen zur Beurteilung der beruflichen Exposition von Typ-IV-Allergene der Standardreihe. Aufgrund publizierter Literatur, epidemiologischer Untersuchungen, arbeitstechnischer Kenntnisse und spezifischer Allergeneigenschaften werden für folgende Typ-IV-Allergene diesbezügliche Empfehlungen vorgestellt: Acrylate/Methacrylate, Epoxidharzsysteme, Dichromat, Kobaltsalze, Nickel, Formaldehyd, (Chlor-)Methylisothiazolone, p-Phenylendiamin, Kolophonium, Thiurame, Mercaptobenzothiazole, Dithiocarbamate, N-Isopropyl-N’-phenyl-p-phenylendia-min, Duftstoffe, Kompositen, Neomycinsulfat. Dadurch wird die Aufklärung und allergologische Beurteilung der Auswirkung von Typ-IV-Sensibilisierungen im Berufsleben entscheidend verbessert.AbstractEvidence-based guidelines about the distribution of type IV allergens of the European standard series in different professions and its occupational relevance are missing. Based on published data, epidemiological investigations, work related knowledge about industrial processes, and allergen specific properties, recommendations are given about the clinical impact in the working environment for the following allergens: Acrylates/Methacrylates, Epoxy resins, Dichromate, Cobalt, Nickel, Formaldehyde, (Chlor-)Methylisothiazolone, p-Phenylendiamine, Colophony, Thiurame, Mercaptobenzothiazole, Dithiocarbamate, N-Isopropyl-N’-phenyl-p-phenylendiamine, Fragrance Mix, Composite Mix, and Neomycinsulfate. These recommendations might improve the clearance rate and allergological evaluation of the occupational relevance of different delayed type sensitizations or allergens.