Otto Saiko
Merck & Co.
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Publication
Featured researches published by Otto Saiko.
European Journal of Pharmacology | 1983
Phil Skolnick; Steven M. Paul; Jacqueline N. Crawley; Edward Lewin; Arnold S. Lippa; Donald Clody; Otto Saiko; Klaus Minck
The imidazopyridines EMD 35993 and EMD 41717 antagonized the anticonflict actions of diazepam and chlordiazepoxide in rodent models which are predictive for anxiolytic action in man. In contrast to other described benzodiazepine antagonists, these compounds did not antagonize either the anticonvulsant or muscle relaxant properties of either benzodiazepine. Both EMD 39593 and EMD 41717 competitively inhibit the binding of [3H]diazepam to brain membranes, but do not exhibit regional differences in potency. These observations suggest that both EMD 39593 and EMD 41717 display some selectivity in antagonizing the anxiolytic properties of benzodiazepines, and as such may be useful tools in identifying neuronal substrates of anxiety.
Archive | 1986
Otto Saiko; Klaus-Otto Dr. Minck; Hans-Peter Wolf
Archive | 1982
Otto Saiko; Klaus-Otto Dr. Minck; Hans-Peter Wolf
Archive | 1979
Hans-Heinrich Hausberg; Volker Koppe; Eike Poetsch; Otto Saiko; Christoph Seyfried
Archive | 1979
Hans-Heinrich Hausberg; Volker Koppe; Eike Poetsch; Otto Saiko; Christoph Dr Seyfried
Archive | 1972
Herbert Nowak; Otto Saiko; Gustav Dr Schorre
Archive | 1982
Hans-Heinrich Hausberg; Volker Koppe; Eike Poetsch; Otto Saiko; Christoph Seyfried
Archive | 1982
Klaus Imrscher; Otto Saiko; Klaus-Otto Dr. Minck; Hans-Peter Wolf
Archive | 1981
Otto Saiko; Klaus-Otto Dr. Minck; Hans-Peter Wolf
Archive | 1979
Hans-Heinrich Hausberg; Volker Koppe; Eike Poetsch; Otto Saiko; Christoph Seyfried