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Dive into the research topics where Otto Saiko is active.

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Featured researches published by Otto Saiko.


European Journal of Pharmacology | 1983

Antagonism of the anxiolytic action of diazepam and chlordiazepoxide by the novel imidazopyridines, EMD 39593 and EMD 41717

Phil Skolnick; Steven M. Paul; Jacqueline N. Crawley; Edward Lewin; Arnold S. Lippa; Donald Clody; Otto Saiko; Klaus Minck

The imidazopyridines EMD 35993 and EMD 41717 antagonized the anticonflict actions of diazepam and chlordiazepoxide in rodent models which are predictive for anxiolytic action in man. In contrast to other described benzodiazepine antagonists, these compounds did not antagonize either the anticonvulsant or muscle relaxant properties of either benzodiazepine. Both EMD 39593 and EMD 41717 competitively inhibit the binding of [3H]diazepam to brain membranes, but do not exhibit regional differences in potency. These observations suggest that both EMD 39593 and EMD 41717 display some selectivity in antagonizing the anxiolytic properties of benzodiazepines, and as such may be useful tools in identifying neuronal substrates of anxiety.


Archive | 1986

Gaba-agonistic imidazo(4,5-c)pyridines useful as pharmaceuticals

Otto Saiko; Klaus-Otto Dr. Minck; Hans-Peter Wolf


Archive | 1982

Imidazo (4,5-c) pyridines, pharmaceutical compositions containing them and process for their preparation

Otto Saiko; Klaus-Otto Dr. Minck; Hans-Peter Wolf


Archive | 1979

Indolealkylamines and processes for their preparation

Hans-Heinrich Hausberg; Volker Koppe; Eike Poetsch; Otto Saiko; Christoph Seyfried


Archive | 1979

Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture

Hans-Heinrich Hausberg; Volker Koppe; Eike Poetsch; Otto Saiko; Christoph Dr Seyfried


Archive | 1972

CERTAIN 8-METHYL-4-HYDROXY-5-METHYLTHIOMETHYL-4H-M DIOXINO/4,5-C/ PYRIDINES

Herbert Nowak; Otto Saiko; Gustav Dr Schorre


Archive | 1982

INDOLALKYLAMINE, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND VERFAHREN ZU IHRER HERSTELLUNG.

Hans-Heinrich Hausberg; Volker Koppe; Eike Poetsch; Otto Saiko; Christoph Seyfried


Archive | 1982

Imidazo(4,5-c)pyridines, pharmaceutical formulations containing them, and their preparation

Klaus Imrscher; Otto Saiko; Klaus-Otto Dr. Minck; Hans-Peter Wolf


Archive | 1981

Imidazo(4,5-c)pyridine, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung Imidazo (4,5-c) pyridines, pharmaceutical compositions containing them and processes for their preparation

Otto Saiko; Klaus-Otto Dr. Minck; Hans-Peter Wolf


Archive | 1979

Process for preparing 3-[4-(4-aryl-1-piperidyl)- butyl]-indoles and the indoles so produced

Hans-Heinrich Hausberg; Volker Koppe; Eike Poetsch; Otto Saiko; Christoph Seyfried

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