Özdem Anğ

Moxifloxacin activity against clinical isolates compared with the activity of ciprofloxacin.

The activity of moxifloxacin, a new 8-methoxyquinolone, was compared in vitro with the activity of ciprofloxacin against clinical strains isolated from various sites of infection. The mode MIC values of moxifloxacin were superior to those of ciprofloxacin against Streptococcus pneumoniae, methicillin-susceptible and -resistant Staphylococcus aureus, Enterococcus spp., Escherichia coli and Acinetobacter spp., while ciprofloxacin was more active against Klebsiella pneumoniae and Pseudomonas spp. Both antibiotics had similar activity against Haemophilus influenzae, Moraxella catarrhalis and Enterobacter spp.

Salmonellae and Salmonellosis in Turkey

Typhoid fever, caused by S. typhi, is a rare disease today in developed countries in where personal hygiene is applied in appreciable levels, clean and adequate water supply is offered, and foods and food-handlers are controlled. In countries where these conditions are not set as it happens in our country, typhoid salmonellosis due to S. typhi are still among significant bacterial infections in all parts of the country. For instance, 128 cases of typhoid fever were reported from Istanbul in 1989. This may not seem worrisome for a city with a population more than 5 million. But while evaluating these numbers, it is important to keep in mind that infectious diseases are underreported in Turkey and the numbers in the official statistics are well below the real numbers. For this reason, the numbers given for typhoid and paratyphoid cases should only be taken to compare the incidences for different years.

An electronmicroscopic study of experimental hematogenous pyelonephritis

This paper consists of an electronmicroscopic study of hematogenous experimental pyelonephritis. In the first 5 days cell degenerations mitochondrial swellings, slight lysosomal increase, rupture of the apical cell membranes, deterioration of the basal labyrinth and a leucocyte-predominant cell infiltration into the interstitial tissue were observed. On the 10th day, beside these common findings, the complete necrosis of the tubular cells was also observed and was supposed to be the result of an increase of lysosomes directly proportional with elapsed time and of the destruction and extreme contraction of the basal membrane. The cause of these destructions was supposed to be primary schaemia and probably the antigen-antibody-complement complex.

Preventive Effects of Trimethoprim, Sulphamethoxazole and the Combination Trimethoprim/Sulphamethoxazole on Experimental Staphylococcic Pyelonephritis in Rats

108 white rats weighing 170–250 gwere given trimethoprim, sulphamethoxazole and the combination trimethoprim/sulphamethoxazole orally and parenterally in order to test the preventive effect of these s

Effects of a New Sulfonamide Combination on Experimental Pyelonephritis

Preventive effect of a sulfamethizole-sulfaethidole combination on experimental hematogenous pyelonephritis was examined on 120 white rats weighing 200–250 g. Two strains of Staphylococcus au

The influence of urine on the in vitro antimicrobial activity of various antibiotics against different Escherichia coli phenotypes.

Background: The influence of urine on the in vitro activities of various antibiotics used in the therapy of urinary tract infections was assessed by the microbroth dilution method in this study. Methods: Thirty Escherichia coli strains were used: 10 E. coli strains susceptible to ampicillin, 10 strains resistant to ampicillin and ampicillin+sulbactam and ten extended spectrum beta-lactamase producer strains. The minimum inhibitory concentrations (MICs) of ampicillin, ampicillin + sulbactam, cephalothin, cefuroxime, ceftriaxone, amikacin, ciprofloxacin, sulfamethoxazole and trimethoprim were performed parallel in Mueller-Hinton broth and human urine by the microbroth dilution method. Results: The MIC90 of all antibiotics except cephalothin were higher in the urine. MICs performed in the urine were found significantly higher than those performed in broth. Conclusions: This study demonstrated that MICs of antibiotics are influenced by the human urine and that MICs of some antibiotics used in the treatment of urinary tract infections may be overestimated by the standard antibiotic testing methods.