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Dive into the research topics where Özgül Paşaoğlu is active.

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Featured researches published by Özgül Paşaoğlu.


Experimental and Toxicologic Pathology | 2003

The effects of sodium phosphate and polyethylene glycol-electrolyte bowel preparation solutions on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat

Bahattin Erdogan; Serap Işıksoy; Emine Dundar; Özgül Paşaoğlu; Cengiz Bal

The aim of the present study is to evaluate the effects of sodium phosphate (NaP) and polyethylene glycol-electrolyte (PEG-EL) colon cleansing solutions on histopathology of 2,4,6-trinitrobenzene sulfonic acid (TNBS) and ethanol (E)-induced colitis in the rat and normal rat colon. The presence of hyperemia, inflammation and ulcer was evaluated to score of macroscopic morphologic damage. The microscopic criteria including ulceration, mucus cell depletion, crypt abscesses, inflammatory cysts, mucosal atrophy, edema, inflammatory cell infiltration, and vascular dilatation were evaluated to determine the extent of inflammatory reaction. Colitis findings were determined on the rats which were administered TNBS-E. Aphthoid lesions were seen 30% and 20 % of rats, respectively, by NaP and PEG-EL solutions in healthy group. Microscopic examination of aphthoid lesions revealed edema within the lamina propria and lymphoid hyperplasia in the mucosa and submucosa without erosion, ulceration and inflammatory cell infiltration. No significant difference was statistically found either macroscopically or microscopically in terms of the effects of saline, NaP and PEG-EL solutions in healthy rats and rats with colitis (p > .05). Under the present conditions, we concluded administration of NaP and PEG-EL solutions did not cause evident morphological changes on the rectal mucosa macroscopically and microscopically, although in a proportion of rats aphthoid lesions seem as a marker of mucosal damage macroscopically.


Rheumatology International | 2005

Conn's syndrome (primary hyperaldosteronism) simulating polymyositis.

Timuçin Kaşifoğlu; Cengiz Korkmaz; Özgül Paşaoğlu

A 44-year-old woman presented with typical polymyositis findings associated with hypokalemia. Abdominal CT as well as plasma renin and aldosterone levels showed a right surrenal adenoma secreting aldosterone. Unilateral adrenalectomy was performed and resolved all the clinical and laboratory manifestations. Hypokalemia should be considered in the differential diagnosis of polymyositis, even in the face of inflammatory cell infiltration in the muscle biopsy.


Joint Bone Spine | 2008

Autoerythrocyte sensitization syndrome (Gardner-Diamond syndrome) associated with cutaneous vasculitis

Döndü Üsküdar Cansu; Timuçin Kaşifoğlu; Özgül Paşaoğlu; Cengiz Korkmaz

Autoerythrocyte sensitization syndrome (ASS) (Gardner-Diamond syndrome) is characterized by painful ecchymotic lesions affecting mostly women with emotional stress. Although it is widely accepted as a non-inflammatory disease, ASS can be accompanied by some autoimmune diseases. In this case report, we present a case with ASS associated with cutaneous vasculitis. We also briefly discuss the possible inflammatory features of ASS.


Pathology & Oncology Research | 2017

Prognostic Significance of CD24 in Clear Cell Renal Cell Carcinoma

Deniz Arik; Cavit Can; Emine Dundar; Sare Kabukcuoglu; Özgül Paşaoğlu

The role of cancer stem cells in the initiation and progression of cancer has become a well-studied area of emerging research, and stem cells with different surface markers have been identified in various types of cancer. CD24 is a membrane protein that acts as the ligand for P-selectin and has been defined as a stem cell marker of colonic cancer. The immunohistochemical expression of CD24 is associated with worse patient outcomes in small cell lung cancer, hepatocellular carcinoma, breast cancer, and colon cancer. In this study, we used immunohistochemistry to determine CD24 expression in clear cell, papillary and chromophobe renal cell carcinoma and investigated its relationship with other clinicopathological parameters and prognosis. A total of 108 cases of clear cell, 12 papillary and 13 choromophobe renal cell carcinoma were examined. Clinicopathological features including age, gender, vascular invasion, tumor necrosis, and T stage were recorded. Clinical stage and overall survival and disease-free survival times were recorded. The immunohistochemical expression of CD24 was classified as low or high based on the percentage and intensity of positive staining. CD24 expression was associated with both tumor grade and recurrence rates. The survival analysis revealed that patients with high CD24 expression exhibited significantly lower overall and disease-free survival. Increased expression of CD24 is related to the prognosis of clear cell renal cell carcinoma. This is the first study identifying a strong association between CD24 expression levels and survival. Thus, CD24 expression may aid in predicting prognosis in clear cell renal cell carcinoma.


Journal of Cancer Research and Therapeutics | 2017

CD105 (endoglin) expression as a prognostic marker of angiogenesis in squamous cell cervical cancer treated with radical radiotherapy

Evrim Metcalfe; Deniz Arik; Tufan Oge; Durmus Etiz; OmerTarik Yalcin; Sare Kabukcuoglu; Özgül Paşaoğlu; SSinan Ozalp

Introduction: Increased levels of endoglin may represent a new reagent of active neovascularization and angiogenesis process in various cancer types. The prognostic value of tumor CD105 (endoglin) expression in cervical squamous cell cancer (CSCC) patients treated with radical radiotherapy (RT) ± chemotherapy was investigated. Materials and Methods: CD105 (endoglin) expression was assessed by immunohistochemical methods in seventy patients, who were treated with radical RT ± chemotherapy for CSCC. The prognostic effects of CD105 on patient and treatment characteristics, local-regional control, and survival were assessed. Results: The median follow-up was 24 (5–99) months for the whole cohort. The median CD105 microvessel density was 55.5 (range; 12–136). Age (≤61 vs. >:61 years; P = 0.015), lymph node metastasis status (absent vs. present; P = 0.028), International Federation of Gynecology and Obstetrics stage (Ib–IIa vs. IIb–IVa; P = 0.036), cycles of concurrent chemotherapy (1–3 vs. 4–6 cycles; P = 0.001), and hemoglobin levels (≤10 g/dL vs. >:10 g/dL; P = 0.006) appeared to associate significantly with overall survival on univariate analysis. Discussion: No correlation was identified between the tumor CD105 (endoglin) expression and survival in CSCC patients treated with radical RT ± chemotherapy.


Journal of Oral and Maxillofacial Radiology | 2015

The importance of the dental examination in the primary diagnosis of Gardner's syndrome

Ömür Dereci; Sinan Ay; Esra Yesilova; Özgül Paşaoğlu

Gardner′s syndrome (GS) is an autosomal dominant, well-documented disease with characteristic systemic and maxillofacial manifestations. The diagnosis of GS is established by the presence of simultaneous findings of intestinal or colorectal polyposis and jaw pathologies. Multiple polyps of GS are likely to become carcinomas at older ages. Cooperation between medical disciplines is important in the diagnosis of GS. Patient with multiple adenoid polyposis should be referred to dental examination in order to discard GS. Dental radiographic examination may be crucial in the primary diagnosis of the disease. In this case report, a case of GS is presented with prominent histologic features and the importance of the dental examination in the diagnosis of GS is discussed.


World Journal of Surgical Oncology | 2010

Perforated mixed carcinoid-adenocarcinoma in transverse colon and at gastroenterostomy site: case report

Enver İhtiyar; Özgül Paşaoğlu; Serdar Erkasap; Barış R Karakaş; Fatih Yaşar

Goblet cell carcinoid of the large intestine is a rare neoplasm, usually located in ascending colon and rectum. A 60-year-old male patient underwent surgery after the diagnosis of acute abdomen. Exploratory laparotomy revealed perforation with a diameter of 1 cm at the site of the previously performed gastroenterostomy and dilatation of the right colic flexure, secondary to a solid obstructive mass located in the mid-portion of transverse colon. Histopathological investigation of the biopsies, taken from the gastroenterostomy site and the tumor, revealed mixed carcinoid-adenocarcinoma with carcinoid component, predominantly composed of goblet cells. Three cycles of FOLFOX-4 protocol was administered. Following respiratory distress secondary to pulmonary metastasis, the patients condition deteriorated and subsequently died in the fourth postoperative month. Our aim with this paper is to point out that more cases should be reported for more effective diagnosis, histopathological study, clinical investigation, treatment and prognosis of this specific neoplasm.


/data/revues/1297319X/00750006/08000389/ | 2009

Autoerythrocyte sensitization syndrome (Gardner–Diamond syndrome) associated with cutaneous vasculitis

Döndü Üsküdar Cansu; Timuçin Kaşifoğlu; Özgül Paşaoğlu; Cengiz Korkmaz


Journal of the American Geriatrics Society | 2005

DISTRIBUTION OF GYNECOPATHOLOGICAL FINDINGS IN GERIATRIC WOMEN

Sinan Özalp; Hüseyin Mete Tanir; Omer T. Yalcin; Salih Kahraman; Özgül Paşaoğlu; Emine Dundar


/data/revues/1297319X/00750006/08000389/ | 2009

Iconographies supplémentaires de l'article : Autoerythrocyte sensitization syndrome (Gardner–Diamond syndrome) associated with cutaneous vasculitis

Döndü Üsküdar Cansu; Timuçin Kaşifoğlu; Özgül Paşaoğlu; Cengiz Korkmaz

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Cengiz Korkmaz

Eskişehir Osmangazi University

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Timuçin Kaşifoğlu

Eskişehir Osmangazi University

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Döndü Üsküdar Cansu

Eskişehir Osmangazi University

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Emine Dundar

Eskişehir Osmangazi University

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Serap Işıksoy

Eskişehir Osmangazi University

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Sare Kabukcuoglu

Eskişehir Osmangazi University

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Deniz Arik

Eskişehir Osmangazi University

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Sinan Özalp

Eskişehir Osmangazi University

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Barış R Karakaş

Eskişehir Osmangazi University

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Cavit Can

Eskişehir Osmangazi University

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