Ozgur Sogut

Primary Hydatid Cyst: An Unusual Cause of a Mass in the Supraclavicular Region of the Neck

Hydatid disease, also known as echinococcosis or hydatidosis, is an infectious disease caused by the cestode Echinococcus. Echinococcus granulosus is the most common Echinococcus species affecting human beings. It may affect any organ and tissue in the body, in particular the liver and lung. Musculoskeletal or soft tissue hydatidosis accounts for about 0.5% 5% of all echinococcal infections in endemic areas, and is almost always secondary to the hepatic or pulmonary disease. Even in regions where echinococcosis is endemic, hydatidosis of cervicofacial region is extremely rare. Herein, we present exceptionally rare case with an unusual localization of primary hydatid cyst in the left supraclavicular region of the neck. Keywords Hydatid cyst; Supraclavicular region; Neck; Unusual localization

Acute myocardial infarction and coronary vasospasm associated with the ingestion of cayenne pepper pills in a 25-year-old male

Capsaicin, one of the major active components of cayenne pepper pills, is an over-the-counter substance with sympathomimetic activity used commonly by young individuals for weight loss. Here we report the case of a previously healthy young male who developed severe chest pain after using cayenne pepper pills for slimming and sustained an extensive inferior myocardial infarction. Electrocardiography combined with a bedside transthoracic echocardiogram confirmed the diagnosis of acute myocardial infarction. The patient denied using illicit substances, and he had no risk factors for coronary artery disease. His medication history revealed that he had recently started taking cayenne pepper pills for slimming. A subsequent coronary angiogram revealed patent coronary arteries, suggesting that the mechanism was vasospasm. We postulate that the patient developed acute coronary vasospasm and a myocardial infarction in the presence of this known sympathomimetic agent. This case highlights the potential danger of capsaicin, even when used by otherwise healthy individuals.

Trauma Scores and Neuron-Specific Enolase, Cytokine and C-Reactive Protein Levels as Predictors of Mortality in Patients with Blunt Head Trauma

This study evaluated serum neuron-specific enolase (NSE), cytokine and high-sensitivity C-reactive-protein (hs-CRP) levels, along with the Glasgow Coma Scale (GCS) and Revised Trauma Score (RTS), as predictors of mortality in the early post-traumatic period, in 100 Turkish patients with blunt head trauma. Overall patient mortality was 27%. There was a significant association between age and mortality, and mortality was negatively correlated with GCS and RTS. Head injury severity (GCS) was significantly related to NSE, hs-CRP, interleukin (IL)-6, IL-8 and tumour necrosis factor (TNF)-α levels. Mortality correlated positively with IL-6, IL-8, TNF-α and hs-CRP levels. NSE, hs-CRP, IL-6, IL-8 and TNF-α levels were significantly higher in non-survivors compared with survivors. GCS score ≤ 8, younger age and NSE levels were significant independent predictors of mortality. During the early post-traumatic period, NSE may be an objective alternative criterion to the GCS, in the management of patients with blunt head trauma.

The characteristics and outcomes of foreign body ingestion and aspiration in children due to lodged foreign body in the aerodigestive tract.

Objective Injury due to foreign body (FB) aspiration and/or ingestion is a common and serious pediatric emergency. Foreign body injury (FBI) most commonly occurs in children younger than 6 years, and the incidence of FBI has increased in recent years. The aim of the present study was to evaluate and compare the characteristics of FBI due to ingestion and aspiration. Methods Data from patients who were hospitalized for FB ingestion and/or aspiration and underwent rigid bronchoscopy and esophagoscopy from 2008 to 2011 were retrospectively evaluated. Foreign body in the upper aerodigestive tract was evaluated with respect to the characteristics of patients, clinical presentation, management strategy, the outcome, and features of FB. Results A total of 192 patients admitted for FB ingestion or aspiration in the pediatric surgery department were evaluated. The mean age was 40.97 (SD, 35.73) months. The majority of patients were younger than 4 years. Foreign bodies were mainly located in the upper esophagus for ingested FBs (60.8%), whereas for aspiration 43% of FBs were in the main right bronchus. A total of 4 patients died. The hospitalization period of patients admitted for FB aspiration was longer than that of patients with FB ingestion. Surgery was performed in 4 patients. The most commonly ingested FBs were coins, whereas seeds were the most commonly aspirated. Conclusion Prevention is the key to dealing with FBIs. Because the frequency of foreign bodies is higher in underdeveloped countries, education of parents regarding the dangers and prevention of aspiration and ingestion is important.

Effect of harmless acute pancreatitis score, red cell distribution width and neutrophil/lymphocyte ratio on the mortality of patients with nontraumatic acute pancreatitis at the emergency department.

BACKGROUND Harmless acute pancreatitis score (HAPS), neutrophile/lymphocyte ratio and red blood cell distribution width (RDW) are used to determine the early prognosis of patients diagnosed with nontraumatic acute pancreatitis in the emergency department (ED). METHODS Patients diagnosed with acute pancreatitis (K 85.9) in the ED according to the ICD10 coding during one year were included in the study. Patients with chronic pancreatitis and those who had missing data in their files were excluded from the study. Patients who did not have computed tomography (CT) in the ED were not included in the study. RESULTS Ultimately, 322 patients were included in the study. The median age of the patients was 53.1 (IQR=36-64). Of the patients, 68.1% (n=226) had etiological causes of the biliary tract. The mortality rate of these patients within the first 48 hours was 4.3% (n=14). In the logistic regression analysis performed by using Balthazar classification, HAPS score, RDW, neutrophile/lymphocyte ratio, age, diabetes mellitus and systolic blood pressure, the only independent variable in determining mortality was assigned as Balthazar classification (OR: 15; 95% CI: 3.5 to 64.4). CONCLUSIONS HAPS, neutrophile/lymphocyte ratio and RDW were not effective in determining the mortality of nontraumatic acute pancreatitis cases within the first 48 hours. The only independent variable for determining the mortality was Balthazar classification.

Factors affecting the clinical outcome of low-voltage electrical injuries in children.

Purpose This study evaluated the clinical features of low-voltage (220–240 V) electrical injuries and their mortality in children. Methods This cross-sectional study evaluated 36 patients younger than 18 years who suffered a low-voltage electrical shock and presented to the emergency department between January 2009 and October 2011. For statistical analysis, Fisher exact test was used for categorical variables, and the Mann-Whitney U test for continuous variables. Results In the 34-month period, 36 patients (27 boys [75%] and 9 girls [25%]) were injured. The mean patient age was 9.19 ± 4.10 years (range, 2–17 years). Of the 36 patients, 5 (13.9%) died. Significant relationships were found between mortality and age (P =0.004), unconscious at the time of admission to the emergency department (P =0.013), the presence of clinical shock (P = 0.005), sinus tachycardia (P = 0.003), and high lactate dehydrogenase levels (P = 0.001). There were also significant relationships between mortality and hospital stay (P = 0.005), intensive care unit stay (P = 0.002), and detection of bacterial growth in blood culture (P = 0.024). By contrast, sex, the presence of an electrical exit wound, degree of the burn, surface area of the burn (%), accompanying flash burn, time elapsed transferring the patient from the accident scene to hospital, incomplete bundle-branch block or ST-wave changes on the electrocardiogram, increased troponin T, and creatine phosphokinase myocardial bundle did not affect mortality. Conclusions Complications such as sepsis and electrolyte imbalance lead to mortality rather than low-voltage electrical injury itself.

The Efficacy of Ankaferd Blood Stopper in Heparin-Induced Hemostatic Abnormality in a Rat Epistaxis Model

Objective. To assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS). Study Design. An experimental study of an animal anterior epistaxis model. Setting. A tertiary care university hospital. Subjects and Methods. Wistar rats were randomized into 4 groups of 7 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ABS; group 3, control, heparin pretreatment, irrigated with saline; and group 4, heparin pretreatment, irrigated with ABS. In all groups, a standardized rat epistaxis model was obtained by cutting the anterior nasal septal mucosa. To control bleeding, compressive dressings were placed after instilling 1 mL of either ABS or saline to the bleeding area. The hemostasis time and amount of nasal bleeding were measured in all groups to compare the treatments without and with ABS. Results. Without heparin pretreatment, ABS shortened the hemostasis time by 1.57 minutes (P = .003) and reduced the amount of the bleeding by 0.35 g (P = .006). With heparin pretreatment, ABS shortened the hemostasis time by 2.86 minutes and reduced the amount of the bleeding by 0.49 g (both P = .002). Conclusion. ABS irrigation was more effective than saline irrigation for treating anterior epistaxis hemostasis in animals using a compressive dressing with or without heparin pretreatment.

The role of oxidative stress and inflammation in the early evaluation of acute non-ST-elevation myocardial infarction: an observational study.

OBJECTIVE We aimed to assess the role of oxidative stress (OS) and inflammation in the early evaluation of initial acute non -ST -elevation myocardial infarction (NSTEMI) compared with unstable angina pectoris (USAP). METHODS Forty-seven (54%) patients with NSTEMI and 40 (46%) with (USAP) were included in this cross-section observational study. We assessed the oxidative stress and inflammation parameters. Statistical analysis was performed using Fishers exact test, Chi-square test, Mann-Whitney U test, Students t-test, and Pearson correlation analysis for assess the correlations between variables. RESULTS Plasma total oxidative stress (TOS) and OS index levels were significantly higher (p<0.001 for both comparisons), in patients with NSTEMI. In addition, white blood cell count (WBC) and high-sensitive C-reactive protein (hs-CRP) levels were significantly higher in patients with NSTEMI (respectively; p<0.001, p=0.02). Age, WBC and low- density lipoprotein cholesterol showed positive correlations with TOS level (Pearson correlation coefficient: r=0.290, p=0.006; r=0.431, p<0.001; r=0.219, p=0.042 respectively), and also age showed positive correlation with OS index (Pearson correlation coefficient; r=0.246; p=0.021). However, the values of the troponin I and creatine kinase-MB fraction did not differ between the two groups (p>0.05 for all). CONCLUSION TOS, OSI, WBC and CRP levels are significantly higher in NSTEMI subject. These data suggest that inflammatory processes and oxidative stress together play a role in the pathogenesis of acute NSTEMI.

Hemostatic Efficacy of Folkloric Medicinal Plant Extract in a Rat Skin Bleeding Model

Objective To assess the in vivo hemostatic effect of a folkloric medicinal plant extract. Subjects and Methods Wistar rats were randomized into four groups of seven. Group 1, a control group, received no pretreatment and was irrigated with saline. Group 2 received no pretreatment and was irrigated with the plant extract. Group 3, a control group, received pretreatment with heparin and was irrigated with saline. Group 4 received pretreatment with heparin and was irrigated with the plant extract. A standardized skin‐bleeding model was created using full‐thickness skin defects on the Wistar rats’ dorsal skin. To control bleeding, compressive dressings were placed after inserting 1 mL of the plant extract or saline into the bleeding area. Hemostasis time and amount of nasal bleeding were measured in all groups to compare the treatments without and with the plant extract. Results Without heparin pretreatment, the folkloric medicinal plant extract shortened the hemostasis time by 1.29 minute and reduced the amount of bleeding by 0.63 g. With heparin pretreatment, the plant extract shortened the hemostasis time by 2.29 minutes and reduced the amount of bleeding by 0.70 g. Conclusion The medicinal plant extract irrigation was more effective than saline irrigation for treating hemorrhagic skin defects in animals using a compressive dressing with or without heparin pretreatment.

Role of Oxidative Stress in the Clinical Outcome of Patients with Multiple Blunt Trauma

OBJECTIVE: This prospective study evaluated serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI), along with the Revised Trauma Score (RTS) and Injury Severity Score (ISS), as predictors of clinical outcome in the early post-traumatic period in patients with multiple blunt trauma (MBT). METHODS: The study included 52 patients admitted to the emergency department with MBT and 40 age-and sex-matched healthy control subjects. RESULTS: The overall MBT patient mortality was 32.7% (17/52). There was no significant association between age and mortality in MBT patients, but there was a negative correlation between mortality and RTS, and a positive correlation between mortality and ISS. TOS levels were significantly higher in nonsurvivors compared with survivors. There was no correlation between TAS or OSI and survival. ISS and RTS showed positive and negative correlations with TOS level, respectively, but neither was significantly related to TAS or OSI. CONCLUSIONS: These findings suggest that TOS, as an early oxidative stress biomarker, may be an objective alternative criterion to the ISS and RTS for managing patients with MBT during the early period following traumatic injury.