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Dive into the research topics where Özkan Özdamar is active.

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Featured researches published by Özkan Özdamar.


Gynecologic and Obstetric Investigation | 2018

The Timing of Embryo Transfer Catheter Removal: Should It be Delayed or Done Immediately A Prospective Randomized Trial

Belgin Devranoğlu; Özkan Özdamar; Yigit Cakiroglu; Mehmet Kucukbas; Meryem Kurek Eken; Emek Doğer

Background/Aims: Data on the timing of catheter removal technique following embryo transfer (ET) are quite limited. We aimed to compare the reproductive outcomes of intracytoplasmic sperm injection (ICSI)/ET cycles in which the transfer catheter was removed immediately with those in which the catheter was removed after a delay period and hereby to evaluate the impact that the time interval before removal of the catheter following embryo deposit may have on the fertility outcomes. Methods: A prospective randomized study was designed. ICSI/ET patients <40 years were randomly assigned to either of the group from which catheter was withdrawn immediately within the first 5 s (Group A) or after a 30 s delay (Group B) following ET. Results: Groups A and B consisted of 147 and 148 patients, respectively. Patient demographics and stimulation characteristics were comparable between the groups. Pregnancy rate was 32.2% (95 of 295) and clinical pregnancy rate was 28.8% (85 of 295), whereas ongoing pregnancy was 24.4% (72 of 295) and implantation rate was 29.6% (100 of 338). The comparison of reproductive outcomes revealed no significant differences in pregnancy (p = 0.933), clinical pregnancy (p = 0.673), ongoing pregnancy (p = 0.590), multiple pregnancy (p = 0.801), and implantation rates (p = 0.979) between the groups. Conclusion: No significant difference was observed in the reproductive outcomes between the groups; thus, there appears no requirement to delay the withdrawal of the catheter to improve the outcomes in ICSI cycles.


Pakistan Journal of Medical Sciences | 1969

The role of maternal serumbeta-HCG and PAPP-A levels at gestational weeks 10 to 14 in the prediction of pre-eclampsia.

Özkan Özdamar; Ismet Gun; Uğur Keskin; Necmettin Koçak; Ercüment Müngen

Objective: We aimed to detect whether maternal serum free β-hCG and PAPP-A levels and NT measurements vary between normal pregnancies and those that subsequently develop pre-eclampsia and to evaluate the role of these screening serum analytes in the prediction of pre-eclampsia. Methods: Using a case-control study design, we identified all women who had been screened by double test within 11+0 and 13+6 weeks of gestation and who had developed pre-eclampsia during the subsequent pregnancy course, over a 6-year period between January 2006 and December 2012 at two tertiary referral hospital. All women who had undergone a double test during that time, without a diagnosis of pre-eclampsia and who had not had any adverse obstetric outcomes, were also identified, and three women among them were randomly selected as controls for each case. Maternal and neonatal data were abstracted from the medical records and PAPP-A, β-hCG, NT and CRL MoM values were compared between the two groups. Results: Although β-hCG values show no statistically significant difference (p=0.882), PAPP-A levels were significantly reduced in the pre-eclampsia group compared to the control group (p<0.001). NT and CRL values showed no significant difference between the two groups (p=0.674 and p=0.558, respectively). Conclusion: Measuring PAPP-A in the first trimester may be useful in the prediction of pre-eclampsia.


European Journal of Obstetrics & Gynecology and Reproductive Biology | 2016

Do younger women with elevated basal follicular stimulating hormone levels undergoing gonadotropin-stimulated intrauterine insemination cycles represent compromised reproductive outcomes?

Belgin Devranoğlu; Özkan Özdamar; Emre Kole; Meryem Kurek Eken; Halenur Bozdağ; Emek Doğer

OBJECTIVE To compare stimulation characteristics and reproductive outcomes in women representing elevated and normal day 3 FSH levels and to evaluate the prognostic significance of day 3 FSH on the reproductive outcomes of gonadotropin-stimulated IUI (GS-IUI) cycles in women <35 years. STUDY DESIGN A cross-sectional study was designed. Unexplained infertility patients at the age ≤36 years, who underwent IUI, following gonadotropin stimulation (GS), were investigated. From 105 women with a day 3 FSH≥ 10U/L, 170GS/IUI cycles were assigned to Group EF; whereas a control group (Group NF, normal FSH) was constituted of 170 cycles with a day 3 FSH levels <10U/L. Demographic and stimulation characteristics as well as reproductive outcomes were compared. Primary outcome measure of this study was the biochemical, clinical and ongoing pregnancy rates. Secondary outcome measures were total gonadotropin dose, duration of gonadotropin stimulation, multiple pregnancy, miscarriage and cycle cancellation rates. RESULTS β-hCG positivity, clinical and ongoing pregnancy rates did not differ between women with normal and elevated FSH levels (p=0.234, 0.282 and 0.388, respectively). Total gonadotropin dose, multiple pregnancy and miscarriage rates were not significantly different between the groups (p=0,181, 0.652 and 0.415, respectively). Duration of stimulation was significantly longer and cycle cancellation rate was significantly higher in Group EF than in Group NF (p=0.005 and 0.021, respectively). CONCLUSION Younger women with elevated day 3 FSH represent comparable reproductive outcomes in GS-IUI cycles to those with normal FSH levels, although they may require longer periods of stimulation and are at higher risk of cycle cancellation. Thus, GS-IUI could be a possible treatment option in this patient group and should not be neglected.


Sao Paulo Medical Journal | 2015

Comparison of maternal and fetal outcomes among patients undergoing cesarean section under general and spinal anesthesia: a randomized clinical trial

Anıl İçel Saygı; Özkan Özdamar; İsmet Gün; Hakan Emirkadı; Ercüment Müngen; Yaşam Kemal Akpak

CONTEXT AND OBJECTIVE As the rates of cesarean births have increased, the type of cesarean anesthesia has gained importance. Here, we aimed to compare the effects of general and spinal anesthesia on maternal and fetal outcomes in term singleton cases undergoing elective cesarean section. DESIGN AND SETTING Prospective randomized controlled clinical trial in a tertiary-level public hospital. METHODS Our study was conducted on 100 patients who underwent cesarean section due to elective indications. The patients were randomly divided into general anesthesia (n = 50) and spinal anesthesia (n = 50) groups. The maternal pre and postoperative hematological results, intra and postoperative hemodynamic parameters and perinatal results were compared between the groups. RESULTS Mean bowel sounds (P = 0.036) and gas discharge time (P = 0.049) were significantly greater and 24th hour hemoglobin difference values (P = 0.001) were higher in the general anesthesia group. The mean hematocrit and hemoglobin values at the 24th hour (P = 0.004 and P < 0.001, respectively), urine volume at the first postoperative hour (P < 0.001) and median Apgar score at the first minute (P < 0.0005) were significantly higher, and the time that elapsed until the first requirement for analgesia was significantly longer (P = 0.042), in the spinal anesthesia group. CONCLUSION In elective cases, spinal anesthesia is superior to general anesthesia in terms of postoperative comfort. In pregnancies with a risk of fetal distress, it would be appropriate to prefer spinal anesthesia by taking the first minute Apgar score into account.


Pakistan Journal of Medical Sciences | 1969

Giant intraoral condyloma accuminatum lesion coexisting with genital condyloma.

Saime Serap Moroğlu Özdamar; Özkan Özdamar; Zafer Küçükodacı

The condyloma acuminatum (venereal wart) is a benign epithelial proliferation that occurs most frequently on the mucous membranes of the perianal and genital areas of men and women. The transmissible etiological agents of this lesion are papillomaviruses. In some rare instances these lesion can also be found in the oral cavity. In this 50-year-old woman; a wide rugose, cauliflower-like, exophytic lesion on the attached gingiva in the anterior region thought to be epulis fissuratum or a giant-cell granuloma turned out to be condyloma acuminatum following the excisional biopsy. This patient also had some genital lesions and tested positive for the human papilloma virus which is to be expected due to fact that intraoral presentation of condyloma acuminatum is a lot more frequent in patients who have anogenital lesions according to the literature. This report describes the etiology, diagnosis, treatment and follow-up an intraoral condyloma.


Journal of Turkish Society of Obstetric and Gynecology | 2017

Intra-cesarean insertion and fixation of frameless intrauterine devices

Ateş Karateke; Abdulkadir Turgut; Özkan Özdamar; Dirk Wildemeersch

Various contraceptive methods are available to postpartum women including hormonal and nonhormonal barriers, as well as injectable forms. Of all the available birth control methods, intrauterine devices (IUD) are felt by many to be the near-ideal form of contraception, and are recommended by advocacy groups, physicians, and gynecological organizations worldwide. Immediate postpartum IUD insertion deserves greater attention because it can provide immediate contraception, prevents repeat unintended pregnancies, and may serve to reduce the incidence or need for secondary cesarean delivery; however, insertion of conventional T-shape IUDs immediately post placenta delivery is limited by their high expulsion and displacement rates. Anchoring of frameless-design IUDs that lack conventional cross-arms to the uterine fundal surfaces has been medically and commercially available throughout Europe for many years. The placement technique is simple, has minimal patient discomfort, and high long-term patient acceptance due to its high degree of uterine compatibility as a consequence of its small size and segmented design. Frameless-design IUD implantation appears to represent a major advance, suitable for general use, due to its lack of timing restraints and its simplicity of attachment, which only requires limited training.


Gulhane Medical Journal | 2017

The Assessment of the Relationship Between Endometrial Polyps and Basal Serum Estradiol Levels in Infertility Patients

Özkan Özdamar; İsmet Gün; Kenan Sofuoğlu

Implantation is a result of a complex interaction between the hormonally primed endometrium and the conceptus (1). Structural abnormalities such as endometrial polyps, uterine fibroids, Mullerian abnormalities and intrauterine adhesions may interfere with this relationship and contribute to implantation failure and infertility. Endometrial polyps are the commonest form of intrauterine pathologies, being reported with prevalances varying between 7.8% and 34.9%, depending on the population studied (2-4). The mechanism by which endometrial polyps compromise the implantation is not clear. Although the high prevalence of endometrial polyps in infertile women suggests a causative relationship between the presence of endometrial polyps and infertility, a direct causal relationship between endometrial polyps and infertility have only been corroborated in a very limited number of studies (5).


Journal of Turkish Society of Obstetric and Gynecology | 2016

Luteal phase support in intrauterine insemination cycles

İsmet Gün; Özkan Özdamar; Ali Yılmaz

Intrauterine insemination (IUI) treatment aims to increase the rate of conception by increasing the chances that the maximum number of healthy sperm reach the site of fertilization. IUI with controlled ovarian stimulation is frequently used in assisted reproduction practice. Although widely used, the efficacy of luteal support in IUI remains controversial. In this article, we aimed to review what we know regarding luteal support in IUI cycles and to adjudicate about the clinical use and benefits of this treatment. Based on the study results available in the literature, it appears to be beneficial to supplement the luteal phase in gonadotropin-stimulated IUI cycles that yield more than one follicle.


Journal of The Turkish German Gynecological Association | 2016

Could S6K1 immunopositivity be used to distinguish early and advanced stages of endometrioid endometrial adenocarcinoma

İsmet Gün; Özkan Özdamar; Zafer Kucukodaci; Murat Muhcu; Dilaver Demirel

OBJECTIVE To assess whether the immunopositivity of S6K1, a crucial effector of the mTOR signaling pathway, varies between early-stage low-grade and advanced-stage high-grade endometrial endometrioid adenocarcinoma (EEA) as well as to discuss its prognostic significance. MATERIAL AND METHODS A total of 22 normal endometrial tissue samples (Control group) and 41 EEA specimens (Study group) were enrolled in the study, and all the samples underwent immunohistochemical staining for S6 kinase alpha (S6K1). The study group was further evaluated in two subgroups; stage 1A, grade 1 (Group 1) and stage ≥1A, grade 2 or 3 (Group 2). Group 2 patients were considered as a poor prognosis for EEA. The samples were examined by two independent pathologists. Statistical analyses were performed using the Students t-test for continuous variables, the Chi-square test for categorical variables, and one-way analysis of variance for the comparison of multiple variables. RESULTS The immunopositivity rate for all the included EEA patients was 56.1%, whereas none of the 22 normal endometrial tissue samples revealed immunoreactivity for S6K1. The immunopositivity rates were significantly different between Groups 1 and 2 [38.1% (8/21) and 75.0% (15/20), respectively, p=0.039]. When S6K1 positivity was used as a criterion of poor prognosis in EEA, the sensitivity, specificity, positive predictive value, and negative predictive value were calculated to be 62%, 75%, 72%, and 65%, respectively (OR: 4.9 and 95% CI: 1.3-18.7). CONCLUSION S6K1 was positive in the majority of EEAs and malignancies at an advanced stage. Higher grade disease had a significantly higher rate of S6K1 positivity. S6K1 immunopositivity appears to be a promising method to predict poor prognosis in EEA.


International journal of reproduction, contraception, obstetrics and gynecology | 2016

Does the number of prior oocyte retrieval practices increase the amount of blood loss in subsequent OPU procedures

Özkan Özdamar; İsmet Gün; Ali Ovayolu; Kenan Sofuoğlu

Background: Though OPU is a safe and simple procedure, it may cause damage to pelvic structures and bleeding. It is unclear whether history of a prior OPU poses any risk of increased blood loss in the OPU. We, herein, aimed to evaluate whether mean blood loss and hematologic parameters vary between women with and without the history of an OPU, in an unexplained infertility population. Methods: A prospective case-control study was conducted through the files of patients who underwent IVF/ICSI-ET between June and December 2013. Unexplained infertility patients with a CBC result were assigned to two groups; those undergoing OPU for the first time (Group 1, n=40) and those who were previously subjected to at least 1 procedure (Group 2, n=13). Blood samples were obtained before the ET. Hemoglobin values and changes were compared between the two groups. Results: Delta hemoglobin value did not significantly differ between the groups (p=0.469) and there were no significant difference between the pre- and post-procedure hemoglobin values in the patients with no and at least one OPUs and the total patient population (p=0.792, 0.259 and 0.442, respectively). Conclusions: Our study results reveal that the amount of the blood loss in OPU does not significantly vary between women subjected to the procedure for the first time and for more than 1 time.

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İsmet Gün

Military Medical Academy

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Kenan Sofuoğlu

Boston Children's Hospital

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Murat Muhcu

Military Medical Academy

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Vedat Atay

Military Medical Academy

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Ismet Gun

Boston Children's Hospital

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Serkan Bodur

University of Pittsburgh

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Tayfun Kutlu

Boston Children's Hospital

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