P. A. Motolese
University of Siena
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Featured researches published by P. A. Motolese.
American Journal of Ophthalmology | 2009
Gianluca Martone; Paolo Frezzotti; Gian Marco Tosi; Claudio Traversi; V. Mittica; Alex Malandrini; Patrizia Pichierri; Angelo Balestrazzi; P. A. Motolese; Ilaria Motolese; Edoardo Motolese
PURPOSE To evaluate the long-term effects of preservative-free and preservative-containing antiglaucoma eye drops on the tear secretion and ocular surface. DESIGN Comparative retrospective study. METHODS A total of 84 patients with bilateral primary open-angle glaucoma or ocular hypertension divided into 5 groups according to type of topical hypotensive therapy and 20 healthy age-matched volunteers were studied. Clinical tests (corneal sensitivity, Schirmer I test, and lachrymal film break-up time), and in vivo confocal microscopy were performed in all patients. RESULTS A significant reduction of the scores was found between groups on topical hypotensive therapy and the control group in all clinical parameters studied (P < .05). In particular, the clinical scores were significantly lower in the preservative medication groups than in the preservative-free group (P < .05). The density of superficial epithelial cells was reduced in all glaucomatous patients, except for the preservative-free group (P > .05), with respect to control subjects (P < .001). On the contrary, the density of basal epithelial cells of glaucomatous preservative therapy groups was higher than control and preservative-free groups (P < .05). Stromal keratocyte activation and the number of beads were higher in all glaucoma preservative groups (P < .05). The number of sub-basal nerves was lower in all glaucoma groups than in the control group (P < .05) and tortuosity was significantly higher in glaucoma than control groups (P < .05). Reflectivity of fibers did not show any significant difference between the 6 groups (P < .05). CONCLUSIONS Glaucomatous patients with chronic treatment show ocular surface alterations. The development of nontoxic antiglaucoma treatment may reduce damage to the ocular surface and improve the compliance and the adherence in the medical therapy.
European Journal of Ophthalmology | 2007
Eduardo Motolese; Rubegni P; Poggiali S; P. A. Motolese; Marotta G; Russo L; D'Ascenzo G; Carcagni Mr; Mario Fruschelli; Ilaria Motolese; Fimiani M
Purpose Eye involvement has long been appreciated in patients with chronic graft versus host disease (cGVHD). In particular, ocular complications are frequent and can be potentially severe in patients with steroid-refractory cGVHD, and therefore necessitate close monitoring. This prospective study was designed to describe eye manifestations of cGVHD in a large series of patients monitoring them before and after 1 year of extracorporeal photochemotherapy (ECP). ECP is a relatively new therapeutic approach based on the biological effects of psoralen 8-methoxypsoralen (8-MOP) and ultraviolet A light (UVA) on mononuclear cells collected by apheresis, and reinfused into the patient. Methods Only patients with steroid-refractory cGVHD under treatment with ECP, who developed cGVHD-related eye symptoms, were selected for the study. Ophthalmologic examination was repeated every 3 months. Only patients with complete recovery of the ocular manifestations and symptoms were considered responsive. Results In our study we observed eye alterations in 24 out of 140 patients (17%) with cGVHD. After 12 months of ECP, 10 out of 21 patients (48%) completely responded to the therapy. In all these cases the contribution of ECP was also essential in all the other organs subject to cGVHD. Conclusions Further studies are necessary to clarify the role of ECP in patients with cGVHD, especially in associated eye manifestations. Although our experience is limited, it suggests that ECP could be a safe and effective therapy for steroid-refractory eye manifestations of cGVHD.
Neurologia I Neurochirurgia Polska | 2010
Simone Ulivieri; Giuseppe Oliveri; P. A. Motolese; Mario Fruschelli; Edoardo Motolese; Felice Menicacci; Paolo Galluzzi; Matteo Bellini; Antonio Giorgio; Paolo Toti; Luigi Pirtoli
Spindle cell lipoma is a rare and distinct variant of soft tissue tumour characterised by spindle cells in which the fat content may be scarce or absent. Most spindle cell lipomas arise as a subcutaneous mass of the neck, shoulders or back. Rarely, they can also be found in unusual sites, such as the oral cavity, larynx, bronchus, breast, and extremities. Localisation of spindle cell lipoma in the orbit has been described in a few cases. We report here on a case of an orbital mass surgically excised in an adult male and discuss the differential diagnosis with other soft tissue tumours with a lipomatous component, such as lipomatous haemangiopericytoma, a rare variant of haemangiopericytoma.
European Journal of Ophthalmology | 2010
Ilaria Motolese; Luigi Mazzera; Paolo Frezzotti; P. A. Motolese; Eduardo Motolese
Purpose. To report a case of isolated conjunctival Bowen disease treated with surgical resection and amniotic membrane transplantation. Methods. Interventional case report. Results. A 70-year-old man was admitted to our clinic with a large conjunctival verrucous plaque well-demarcated in the correspondence of the bulbar conjunctiva in the superior quadrant of the left eye with involved limbal and corneal surface. Ophthalmologic examination on slit-lamp examination and color fundus photographs were carried out before surgery and the results were evaluated. Conclusions. Treatment options and treatment studies of Bowen disease are difficult because there are a variety of different protocols and the success of the management depends on several factors (body site, lesion size, number of lesions, and thickness). In the conjunctival localization of the lesion, amniotic membrane transplantation appears to be a useful therapeutic choice after surgical resection of the lesion used to reconstruct ocular and conjunctival surface.
European Journal of Ophthalmology | 2010
Ilaria Motolese; P. A. Motolese; Paolo Frezzotti; Mario Fruschelli; Eduardo Motolese
Purpose Scleral rupture due to bulb bursting can result from a heavy contusion. Owing to refined surgical techniques and the use of antibiotics and cortisone-based medication, more conservative concepts have followed. In major ruptures, the results were almost always very poor, with atrophy or subatrophy of the eyes. Methods A 63-year-old man with major left ocular trauma and intraocular lens dislocation in the subconjunctival area was referred to the authors for clinical and surgical evaluation. Results Surgery was performed 3 weeks after the trauma to allow for improvement in the patients condition. The reabsorption of a palpebral-frontal hematoma, which made bulb exploration almost impossible, was fundamental in order to proceed. After 1 year, the best-corrected visual acuity was 0.9. In fact, great improvements in surgical techniques in recent years have allowed us to consider the problem of major rupture in a new way, both technically and from an organizational point of view. Conclusions In terms of organization, the concept of urgent surgical procedures must be reevaluated, because besides traumatic damage, incomplete surgical measures may result. This makes all treatment useless, in both barely equipped and highly specialized centers.
Il Giornale di chirurgia | 2009
Simone Ulivieri; P. A. Motolese; Ilaria Motolese; Eduardo Motolese; Felice Menicacci; P. Gennari; Clelia Miracco
Il Giornale di chirurgia | 2010
Mario Fruschelli; P Esposti; Ilaria Motolese; G. Esposti; P. A. Motolese; Eduardo Motolese; Giuseppe Filosomi; Giuseppe Oliveri; Simone Ulivieri
GIORNALE ITALIANO DI VITREORETINA | 2010
Ilaria Motolese; P. A. Motolese; Paolo Frezzotti; Mario Fruschelli; Eduardo Motolese; G. Esposti; C. Bovone; P Esposti
Archive | 2009
Simone Ulivieri; P. A. Motolese; Ilaria Motolese; Eduardo Motolese; Felice Menicacci; P. Gennari; Clelia Miracco
BOLLETTINO DI OCULISTICA | 2009
Eduardo Motolese; K. Platari; M. C. Sparagna; P. A. Motolese