P. C. Srinivasan

A simple route to indole-2,3-quinodimethane - a facile synthesisof carbazoles

Abstract 2,3-Dimethylindole is easily converted intoN-benzoyl-2,3-dibromo methylindole, the latter upon treatment withsodium iodide in DMF in the presence of a suitable dienophilefurnishes a carbozole derivative.

Synthesis of 4-substituted-1,2,3,4-tetrahydro-β-carbolines via intramolecular radical cyclisation and Heck reaction

Abstract A convenient method for the synthesis of 4-substituted-β-carbolines from the corresponding N-allylisogramine derivative is reported using intramolecular free radical cyclisation or Heck reaction.

Synthesis of 2,2′-Biindolyls; Potential Intermediates for Indolocarbazole Alkaloids

Abstract The synthesis of 2,2′-biindolyls oxygenated in the benzenoid ring is reported. Wittig-Horner reaction of the phosphonate esters of 1-benzenesulfonyl-2- bromomethyl-3-substituted indoles with o-nitrobenzaldehydes followed by deoxygenation with triethyl phosphite gave 2,2′-biindolyls.

One pot synthesis of 4-hydroxy-3-substituted carbazoles via sulfoxide stabilised carbanion

Abstract A convenient method for the synthesis of 4-hydroxy-3-substitutedcarbazoles (Potential intermediate for pyridocarbazole alkaloids) from ethyl 5-methoxy-2-phenylsulfinylmethyl-1-phenylsulfonylindole-3-carboxylate is reported.

Synthesis of quinolono[4,3-b] and [3,4-b]carbazoles potential DNA binders

Abstract 2-and 3-β-[arylvinyl]indoles, obtained by Wittig-Horner reaction of the corresponding N-benzenesulfonylbromomethylindoles with o-nitrobenzaldehydes, gave 2- and 3-arylcarbazoles respectively upon Diels-Alder reaction with DMAD. On reductive cyclisation, these carbazoles gave the title compounds.

Unusual Oxidation of 2 (or 3)-Methylindole Derivatives with Active Manganese Dioxide

Abstract Oxidation of 5-methoxy-1-phenylsulfonyl-2-methyl indole-3-aldehyde (3) with active manganese dioxide to the corresponding indole-2,3-dialdehyde (4) and similar reactions are reported.

A facile synthesis of 2-[4′-dimethylaminophenyl]-3-aryl-β-carbolinium phenylsulfonates

Abstract A convenient method for the synthesis of 2-[4′-dimethylaminophenyl]-3-aryl-β-carbolinium phenylsulfonates from the corresponding 2- N ′-aryliminomethylene-3-β-arylvinylindoles by thermal oxidative cyclization is reported.

MICROWAVE-INDUCED SYNTHESIS OF NITROSTILBENES UNDER NEAT CONDITION

Nitrostilbenes 3a–e were synthesized in good yield using microwave under neat conditions, whereas heating at 90°C resulted in poorer yields of products.

Synthesis of 3-Aryl-5h-Pyrido[4,3-b]indoles

Abstract 3-aryl-γ-carbolines (8) were synthesised by the thermal decomposition of 3-azidomethyl-2-(β-arylvinyl)-1-phenylsulfonyl indole (6).

A new synthesis of angularly substituted bicyclic systems via an anionic oxy-cope rearrangement

Abstract A general synthesis of trans bicyclic carbinols with an angular methyl substituent using the anionic oxy-Cope rearrangement is reported. The carbinols 13a , l3b , 14a , 14b and 15 furnish the bicyclic carbinols 16a , 16b 17a , 17b and 18 when treated with potassium hydride in 1,2-dimethoxyeth ane.