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P.D. Howes

University of California, Berkeley

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Publication

Featured researches published by P.D. Howes.

Journal of Medicinal Chemistry | 2007

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate

M.J. Slater; E.M. Amphlett; D.M. Andrews; G. Bravi; George Burton; A.G. Cheasty; John Andrew Corfield; M.R. Ellis; R. Fenwick; S. Fernandes; Rossella Guidetti; David Haigh; C.D. Hartley; P.D. Howes; Deborah Lynette Jackson; Richard L. Jarvest; Victoria Lucy Helen Lovegrove; Katrina Jane Medhurst; Nigel R. Parry; H. Price; P. Shah; O.M.P. Singh; R. Stocker; Pia Thommes; C. Wilkinson; A. Wonacott

Journal of Hepatology | 2007

[594] GSK625433; A NOVEL AND HIGHLY POTENT INHIBITOR OF THE HCV NS5B POLYMERASE

F. Gray; E.M. Amphlett; H. Bright; L. Chambers; A.G. Cheasty; R. Fenwick; David Haigh; D. Hartley; P.D. Howes; Richard L. Jarvest; F. Mirzai; F. Nerozzi; Nigel R. Parry; M.J. Slater; Stephen A. Smith; Pia Thommes; C. Wilkinson; E. Williams

Archive | 2003

1-acyl-pyrrolidine derivatives for the treatment of viral infections

David GlaxoSmithKline Haigh; Charles David Hartley; P.D. Howes; Deborah Lynette Jackson; Pritom Shah; Martin John GlaxoSmithKline Slater

Archive | 2005

4-methoxymethyl-pyrrolidine-2-carboxylic acid compounds and derivatives thereof as hepatitis c virus inhibitors

Rossella Guidetti; David GlaxoSmithKline Haigh; Charles David Hartley; P.D. Howes; F. Nerozzi; Stephen Allan Smith

Abstracts Of Papers Of The American Chemical Society | 2007

Identification of GSK625433: A novel clinical candidate for the treatment of hepatitis C.

David Haigh; E.M. Amphlett; G. Bravi; H. Bright; V. Chung; C.L. Chambers; A.G. Cheasty; M.A. Convery; M.R. Ellis; R. Fenwick; D.F. Gray; C.D. Hartley; P.D. Howes; Richard L. Jarvest; Katrina Jane Medhurst; A. Mehbob; D. Mesogiti; F. Mirzai; F. Nerozzi; Nigel R. Parry; N. Roughley; T. Skarzynski; M.J. Slater; Stephen A. Smith; R. Stocker; C.J. Theobald; P.J. Thomas; Pia Thommes; J.H. Thorpe; C. Wilkinson

Archive | 2006

Preparation of 4-(methoxycarbonyl)pyrrolidine-2-carboxylic acid derivatives as hepatitis C virus inhibitors.

Rossella Guidetti; David Haigh; C.D. Hartley; P.D. Howes; F. Nerozzi; Stephen A. Smith

Archive | 2007

Preparation of azolylmethylpyrrolidinecarboxylates for treating viral infections

David Haigh; C.D. Hartley; P.D. Howes; Richard L. Jarvest; Linos Lazarides; F. Nerozzi; Stephen A. Smith

Archive | 2007

2-Heteroarylmethyl-4-pyrazin-2-yl-N-acyl pyrrolidine compounds as antiviral agents, their preparation, pharmaceutical compositions, and use for treatment of hepatitis C.

David Haigh; C.D. Hartley; P.D. Howes; Linos Lazarides; F. Nerozzi; Stephen A. Smith

Archive | 2006

Preparation of 4-(pyrazin-2-yl)pyrrolidine-2-carboxylic acid derivatives as hepatitis C virus inhibitors.

Rossella Guidetti; David Haigh; C.D. Hartley; P.D. Howes; F. Nerozzi; Stephen A. Smith

Archive | 2004

Synthesis of 1-acyl-pyrrolidine derivatives for the treatment of viral infections.

David Haigh; C.D. Hartley; P.D. Howes; Deborah Lynette Jackson; P. Shah; M.J. Slater

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Collaboration

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C.D. Hartley

GlaxoSmithKline

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F. Nerozzi

University of California

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Stephen A. Smith

University of Michigan

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Rossella Guidetti

University of California

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Deborah Lynette Jackson

University of California

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Richard L. Jarvest

GlaxoSmithKline

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Nigel R. Parry

GlaxoSmithKline

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Pia Thommes

GlaxoSmithKline

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Charles David Hartley

University of California

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David GlaxoSmithKline Haigh

University of California

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