P. E. Stanley

Commercially available fluorometers, luminometers and imaging devices for low-light level measurements and allied kits and reagents: survey update 6.

This survey was compiled in May and June 1999 and includes products not covered in the previous six surveys since 1992. See Update 5 completed in July 1997 for references to previous surveys (Stanley PE, J Biolumin Chemilumin 1997; 12:61-78). Technical details are provided together with company address and contact information including email and website where known. Products include: Luminometers, radiometers, fluorometers (sometimes spelled fluorimeters), low-light imaging CCD cameras, kits and allied reagents and kits.

Triboluminescence: 1968-1998.

The journal continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence, and which have up to 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named Journal these searches are expanded to reflect the Journal’s wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemiluminescence but also fluorescence, time-resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence, etc. The compilers would be pleased to receive any comments from the readership. Contact by e-mail: L.J. Kricka (larry_kricka@path1a.med.upenn.edu), and P.E. Stanley (stanley@LUMIWEB.COM). Copyright

Sonoluminescence: 1996–1998

The journal continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence, and which have, up to 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named Journal these searches are expanded to reflect the Journals wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemi--luminescence but also fluorescence, time-resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence, etc. The compilers would be pleased to receive any comments from the readership. Contact by E-mail: L. J. Kricka (larry_kricka@pathla.med. upenn.edu), and P. E. Stanley (stanley@lumiweb.com). Copyright 1999 John Wiley & Sons, Ltd.

BIOLUMINESCENT FUSION CONJUGATES AND BIOLUMINESCENT IMMUNOASSAYS : 1988-1998

The first part of this survey focuses on immunoassays and related ligand:binder assays (receptor:ligand, DNA probe) that use either a luciferase or a photoprotein as a label. In addition, references to assays that use a conventional label detected using a bioluminescent assay are included. The second part of the survey collects together references to publications on recombinant fusion proteins in which one of the fused proteins is bioluminescent (e.g., a luciferase or a photoprotein). References are cited by year and then alphabetically by first author. Copyright 1999 John Wiley & Sons, Ltd.

Time-resolved fluorescence: 1996-1998

Luminescence continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence which, up until 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named journal these searches are expanding to reflect the journals wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemiluminescence but also fluorescence, time resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence. The compilers would be pleased to receive any comments from the readership. Copyright 1999 John Wiley & Sons, Ltd.

Assays using digital fluorescence: 1985–1998

Luminescence continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence which, up until 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named journal these searches are expanding to reflect the journals wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemiluminescence but also fluorescence, time resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence. The compilers would be pleased to receive any comments from the readership. Contact by e-mail: L.J. Kricka: larry_kricka@path1a.med.upenn.edu or P.E. Stanley: Stanley@LUMIWEB.COM Copyright 1999 John Wiley & Sons, Ltd.

In memoriam: A life scientific ‐ John Woodland ‘Woody’ Hastings (1927–2014)

* Correspondence to: Larry Kricka, Dept of Pathology & Lab Medicine, Univ of Pennsylvania Medical Center. E-mail: kricka@mail.med.upenn.edu 95 J. Woodland (Woody) Hastings (1927–2014) (Fig 1) died in Cambridge, MA on 6 August 2014 due to pulmonary fibrosis. He was 87. Woody was the Paul C. Mangelsdorf Professor of Natural Sciences at Harvard University and a leader in a number of fields of basic biology, but his primary focus was bioluminescence. His deep curiosity about the natural world was the engine that drove his science and discovery was his goal, no matter by whom, and he took delight in not only his own insights, but also those of others. He was always questioning. He was generous to all of his students and colleagues. His diversity of interests led him and his lab to far-reaching discoveries not only in bioluminescence, but also in the areas of chronobiology, quorum sensing by bacteria and resonance energy transfer. His pursuits extended out from his cell biology center all the way from molecular biology and genetics to evolution and ecology. Woody was both a mechanistic and a holistic biologist, seeking to understand both ‘how?’ and ‘why?’ questions. In many respects, he was the natural successor to his prodigious PhD mentor, E. Newton Harvey, who is often considered the ‘father of bioluminescence.’ Woody clearly followed in Harvey’s footsteps and made seminal contributions to our understanding of bioluminescence, particularly in bacteria, dinoflagellates, cnidarians, ctenophores, fireflies and fishes. Woody was a freewheeling thinker, willing to entertain and encourage differing ideas. His breadth of knowledge led to synthesis and new insights. His papers, which spanned 61 years and numbered over 400, were often co-authored with his students or colleagues and represent a steady flow of incremental reports of his lab’s progress in unraveling the mysteries of bacterial and dinoflagellate bioluminescence, and with occasional forays into other areas. He also undertook sweeping synthetic reviews of general luminescence or a particular taxon, akin to the approach of his mentor Harvey. Bioluminescence studies today have exploded far beyond the limits of what could be contained within the pages of the Harvey ‘bioluminescence bible’ of 1952, but Woody’s wonderful book Bioluminescence: Living Lights, Lights for Living (2013), co-authored by his long-time colleague Therese Wilson, captures the essence of the overarching view of bioluminescence that would have made Harvey proud. Woody’s lab was a lively place of ‘controlled chaos’ that spawned current leaders in not only bioluminescence, but other fields as well. It was the synergism and freedom between Woody and his graduate students, post-docs and colleagues that led to major advances in a number of areas of biology. Bioluminescence was his core area of interest. Throughout his long career his two focal groups were luminous bacteria and dinoflagellates, but his focus expanded to other groups when the opportunity arose.

The biennial International Bioluminescence and Chemiluminescence Symposium series: a 35-year heritage.

The first International Bioluminescence and Chemiluminescence will encompass the theory and applications of bioluminescence Symposium was held in Brussels, Belgium in 1978. The genesis of the meeting came from the friendship that grew up between Dr Phil Stanley and Prof Eric Schram (Vrije Universiteit, Brussels, Belgium) who had met a number of times at liquid scintillation conferences in the 1970s. Both had ongoing work on assays based on bioluminescence. At that time, there was an increasing interest, both academic and commercial, in these assays and although Phil Stanley was living in Australia at the time (no emails or faxes then, just Telex!), they prepared a draft schedule and attracted enough investigators to make up a worthwhile conference. In the end, there were 56 presentations and some 130 delegates. With this number of presentations, mainly of new work, it was necessary to have them published. This was before the days of word processors and so we depended on camera-ready copy and found a publisher in California to print and mail the proceedings at an affordable price (1). Following the first symposium in Brussels, it has been held at Chemilumin 1986/7;1:77–145. 3. Shen X, Yang X-L, Cui ZJ, Kricka LJ, Stanley PE, editors. Proceedings of locations around the world: San Diego, CA, USA (1980), Birmingham, UK (1984), Freiburg, Germany (1986), Florence, Italy (1988), Cambridge, UK (1990), Banff, Canada (1993), Cambridge, UK (1994), Woods Hole, MA, USA (1996), Bologna, Italy (1998), Monterey, CA, USA (2000), Cambridge, UK (2002), Yokohama, Japan (2004), San Diego, CA, USA (2006), Shanghai, China (2008), Lyon, France (2010) and Guelph, Canada (2012). A pictorial record of the symposia, beginning with the 10th symposium in Bologna, Italy can be found on the International Society for Bioluminescence and Chemiluminescence (ISBC) website (http://www.isbc.unibo.it/). The scope and content of the meetings are contained in the University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA meeting abstracts published in this Journal (beginning with the abstracts for the 4th International Symposium on Bioluminescence & Chemiluminescence in Freiburg in 1986) (2) and the proceedings that were published for the first 15 symposia (3). These reflect the progress, changing scope and burgeoning commercial applications of both bioluminescence and chemiluminescence (e.g. clinical immunoassays, protein and nucleic acid blotting, food testing, reporter genes). Starting in 1988 at the meeting in Florence, Italy, the symposia have provided the venue for the award of the Marlene DeLuca prize (generously sponsored by Dr Fritz Berthold). This prize is awarded to symposium participants under the age of 35 and is given in memory of Dr Marlene DeLuca who made major contributions to the science of bioluminescence (4). The fundamental aspects of bioluminescence and chemilumin-

Luminescence literature. Green fluorescent protein (GFP).

The journal provides comprehensive literature searches on all aspects of luminescence which will be published in most issues. These lists have been produced regularly since 1986—some by year and some by specialized topic. This survey covers the 2002 literature on green fluorescent protein (GFP); see volume 17, page 386, and for previous surveys on this topic. GFP is now used extensively, as reflected by the large number of hits in literature searches for GFP (>1200 for 2002). This survey of the 2002 GFP literature is restricted to publications in which GFP is a major theme. In order to maximize their usefulness, future surveys of GFP will focus on sub-topics of GFP technology.

LUMINESCENCE ON THE INTERNET

This is the first in an occasional survey of Internet sites relating to luminescence. This is just a small selection of available sites and readers are reminded that web pages are sometimes very temporary in nature. The authors welcome details of additional sites of interest to the readers of this journal. Copyright 1999 John Wiley & Sons, Ltd.