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Featured researches published by P. Frimat.


Revue D Epidemiologie Et De Sante Publique | 2011

Relationship between psychosocial factors at work and incidence of perceived health problems in the GERICOTS cohort.

J.-L. Edmé; J. Facq; P. Frimat; M. Vezina

BACKGROUND The objective of this study was to investigate the relationship between the incidence of health problems and the psychosocial work environment in a French occupational cohort. METHODS Among the 2062 employees in the North of France who participated in the GERICOTS survey between 1999 and 2004, 1154 subjects who kept the same full-time shift in the same firm during the study period (797 men and 357 women) were included. Job strain was assessed using Karaseks model--the strain profile (high psychological demand and low decision latitude) and the iso-strain profile (strain profile and low social support)--and Siegrists model, Effort-Reward Imbalance (ERI) (high effort and low rewards). Perceived health status was assessed using the four dimensions of the Nottingham Health Profile (emotional reactions, sleep, social isolation, pain). The results are given by the odds ratio adjusted for age, occupational category, and size of firm. RESULTS At baseline, higher prevalence of health problems was found in workers with job strain, e.g., between emotional reactions and iso-strain for men, OR=3.50 (2.19-5.60) and for women, 2.64 (1.39-5.04) or between sleep disorders and ERI for men, OR=2.41 (1.71-3.40) and for women, OR=2.41 (1.39-4.20). Longitudinal analysis showed a significant relationship between incidence of health problems and level of job strain in 1999, e.g., between sleep disorder incidence and strain profile, OR=1.89 (1.16-3.06) and ERI, OR=2.20 (1.43-3.38). CONCLUSION These results show a significant relationship between perceived health and job stress in 1999 but also between incidence of health problems between 1999 and 2004 and job strain in 1999.


Revue D Epidemiologie Et De Sante Publique | 2006

Prospective evaluation of the impact of a change in the organization of work on perceived stress and health in assembly-line workers in an automobile plant

A. Leroyer; Kraemer-Heriaud H; Marescaux L; P. Frimat

Background Although the competitive climate of the automobile industry is modifying the organization of work in French plants, the health consequences of these changes have not been investigated. The objective of this study was to determine the health impact on employees of an automobile manufacturing plant in northern France of a change to a “Total Quality Management“ type of organization. Methods This before-and-after study concerned 80 factory employees. The health impact of their work was measured before the change and then 4 and 12 months after the reorganization began, with a French version of the Job Content Questionnaire, which assesses stress at work, a self-rated health scale, and the rate of infirmary visits. Paired comparisons were used to assess before-and-after changes. Results Scores for psychological and physical demands increased significantly at 4 and 12 months after the organizational changes began, while the self-rated health score diminished significantly during both follow-ups. Decision latitude and social support scores remained unchanged during follow-up, and the number of subjects under stress in the study group (high psychological demands and low decision latitude) did not increase significantly. Finally, the rate of infirmary visits increased significantly during the study period. Conclusion These results show that employees’reaction to these organizational modifications differed according to the scale studied and that their overall perceptions were more complex than expected in view of the changes that occurred.


Journal of Toxicology and Environmental Health | 2013

Influence Of Delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Selected Lead Exposure Biomarkers in a Cohort of Ex-Smelter Workers

A. Leroyer; Bruno Leleu; Betty Dehon; P. Frimat; Franck Broly; Catherine Nisse

Lead (Pb) body burden and toxicity may be influenced by genetic polymorphisms. The aim of this study was to investigate the influence of G177C delta-aminolevulinic acid dehydratase (ALAD) polymorphism (rs1800435) on selected Pb exposure biomarkers in a population of workers highly exposed to this metal in the past. A cross-sectional survey was conducted between 2007 and 2009 within the cohort of ex-employees of a smelter in the north of France that closed down in 2003. A questionnaire was completed by each participant and blood samples enabled determination of Pb levels and ALAD polymorphism. Five parameters estimating the Pb body burden and its variations were studied: last blood lead level (BLL) during activity, cumulative blood Pb index, BLL at the time of the study, and absolute and percent changes in BLL after cessation of metal exposure. Multiple regression models were used to evaluate links between ALAD polymorphism and the selected Pb exposure biomarkers. Two hundred and four men were included. At the time of inclusion, the median age was 53.5 yr. The median duration of Pb exposure was 25 yr and the median latency since end of exposure was 5.6 yr. The frequency of ALAD-2 allele was 9.3%, with 34 subjects being heterozygous (ALAD1-2) and 2 homozygous (ALAD2-2). According to genotype, there was no significant difference for any of the five selected Pb exposure biomarkers. These results lend support to the notion that ALAD polymorphism exerts no marked impact on Pb body burden.


Revue Francaise D Allergologie Et D Immunologie Clinique | 2002

Allergènes en milieu de soins : étiologie, épidémiologie et manifestations cliniques

I. Gargouri; S. Fantoni; M.L. Masmoudi; R. Gharbi; P. Frimat

Resume En milieu de soins, de nouvelles substances ne cessent d’apparaitre aussi bien dans le domaine du diagnostic et du soin, que dans celui de l’hygiene, de la maintenance et de l’entretien de l’equipement et des locaux. Ainsi, les manifestations allergiques sont frequentes et leur prevalence a tendance a s’accroitre. Cet article presente une vision actuelle des maladies allergiques rencontrees chez le personnel hospitalier. Des effets irritants et allergiques sont possibles tant sur le plan respiratoire que muqueux. La prevention doit faire appel, dans la mesure du possible, a la substitution de produits reputes allergisants par d’autres non ou moins allergisants.


Journal of Occupational Medicine and Toxicology | 2011

A case study on co-exposure to a mixture of organic solvents in a Tunisian adhesive-producing company.

Imed Gargouri; Moncef Khadhraoui; Catherine Nisse; A. Leroyer; Mohamed Larbi Masmoudi; P. Frimat; Daniel Marzin; Boubaker Elleuch; Denis Zmirou-Navier

Objectivesto assess environmental and biological monitoring of exposure to organic solvents in a glue-manufacturing company in Sfax, Tunisia.MethodsExposure of volunteer workers, in the solvented glue-work-stations, in the control laboratory and in the storage rooms of the finished products, was assessed through indoor-air and urine measurements. Informed consent of the workers was obtained.Results and discussionThe exposure indexes were found with high values in the solvented workshop as well as in the control laboratory and were respectively, 8.40 and 3.12. These indexes were also correlated with hexane and toluene indoor air concentrations. As to urine, the obtained results for the 2,5-hexandione and hippuric acid, metabolites of hexane and toluene, respectively, were in accord with the indoor-air measurements, with an average of 0.46 mg/l and 1240 mg/g of creatinine.ConclusionThis study assessed for the first time biological exposure to organic solvents used in Tunisian adhesive industries. Although values are likely to underestimate true exposure levels, some figures exceed European and American occupational exposure guidelines.


Journal of Occupational Rehabilitation | 2010

Factors Related to Return to Work by Women with Breast Cancer in Northern France

S. Fantoni; Charlotte Peugniez; Alain Duhamel; Joanna Skrzypczak; P. Frimat; A. Leroyer


Archives Des Maladies Professionnelles Et De L Environnement | 2010

L’eczéma des mains, quelles conséquences, quelle réparation ?

P. Frimat


Archives Des Maladies Professionnelles Et De L Environnement | 2011

Prévalence des accidents professionnels d’exposition au sang chez le personnel soignant au Togo (Afrique)

K. Kara-Pékéti; H. Magnang; J.-S. Bony; H. Robin; P. Frimat


Archives Des Maladies Professionnelles Et De L Environnement | 2014

Plainte ordinale après déclaration d’une maladie professionnelle par le médecin du travail. Une tentative d’intimidation de la part des employeurs ou des erreurs de rédaction ?

S. Fantoni-Quinton; P. Frimat; D. Choudat


Revue Francaise D Allergologie Et D Immunologie Clinique | 2008

Orientation professionnelle de l’atopique☆

P. Frimat; S. Fantoni-Quinton

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P. Desobry

Environmental Defense Fund

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Annie Sobaszek

Lille University of Science and Technology

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