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P. J. Claes

Katholieke Universiteit Leuven

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Journal of Chromatography A | 1984

Determination of the component ratio of commercial gentamicins by high-performance liquid chromatography using pre-column derivatization

P. J. Claes; Roger Busson; Hubert Vanderhaeghe

Commercial samples of gentamicin from different origins were analyzed by paired-ion high-performance liquid chromatography (HPLC) on a C18 bonded phase. The procedure uses pre-column derivatization with a omicron-phthalaldehyde-mercaptoacetic acid reagent and UV detection (350 nm). The ratios of the four gentamicin components (C1, C1a, C2a and C2) were determined and compared with the compositions obtained by an independent method based on 13C NMR spectrometry. Quantitation by HPLC, based on peak heights and peak areas, was performed with the aid of an external standard, which was an artificial mixture of the four components. The latter were prepared by separation of the gentamicins C1, C2 + C2a and C1a by chromatography on silica gel, followed by chromatography of the C2 + C2a fraction on a cellulose phosphate column.

Journal of Medicinal Chemistry | 1991

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)2'-deoxyuridine are equipotent to (E)-5-(2 bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

Piet Wigerinck; Christophe Pannecouque; Robert Snoeck; P. J. Claes; E. De Clercq; Piet Herdewijn

Journal of Virology | 1970

Polyacetal Carboxylic Acids: a New Group of Antiviral Polyanions

P. J. Claes; An Billiau; E. De Clercq; Jan Desmyter; E. Schonne; H. Vanderhaeghe; P. De Somer

Journal of Medicinal Chemistry | 1991

Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines

Piet Wigerinck; Robert Snoeck; P. J. Claes; E. De Clercq; Piet Herdewijn

Journal of Medicinal Chemistry | 1991

New derivatives of kanamycin B obtained by modifications and substitutions in position 6". 1. Synthesis and microbiological evaluation

Ann Vanschepdael; Jacques Delcourt; M. Mulier; Roger Busson; Ludo Verbist; Hj. Vanderhaeghe; Marie-Paule Mingeot-Leclercq; Paul M. Tulkens; P. J. Claes

Journal of Medicinal Chemistry | 1991