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Featured researches published by P. Krause.


Journal of Hypertension | 2004

High prevalence and poor control of hypertension in primary care: cross-sectional study.

Arya M. Sharma; Hans-Ulrich Wittchen; Wilhelm Kirch; David Pittrow; Eberhard Ritz; Burkhard Göke; Hendrik Lehnert; Diethelm Tschöpe; P. Krause; Michael Höfler; Hildegard Pfister; Peter Bramlage; Thomas Unger

Objective To report: (1) on the background, design and methods of the Hypertension and Diabetes Risk Screening and Awareness (HYDRA) study, (2) on the point prevalence of hypertension in primary care and (3) on the proportion of treated, controlled, and uncontrolled hypertension. Design Cross-sectional point prevalence study. Setting Representative nationwide sample of 1912 primary care practices in Germany. Participants A total of 45 125 unselected primary care attendees. Main outcome measures Prevalence of hypertension based on doctors diagnosis, self-reported diagnosis, and blood pressure (BP) measurements. Results A total of 39% of all patients and 67% of patients aged 60 years or older, respectively, were diagnosed by their doctors as having hypertension. Eighty-four percent of diagnosed patients were on antihypertensive medication, 57% of which were rated by the physician as well controlled. When hypertension was defined as either current BP levels ⩾ 140/90 mmHg and/or current antihypertensive medication, the total point prevalence increased to 50%, while treatment and control rates (BP < 140/90 mmHg) dropped to 64 and 19%, respectively. Conclusions Extrapolation of these findings to the entire primary care patient population seen in the over 20 000 primary care practices in Germany suggests that on an average day, over 700 000 patients with elevated BP are seen by primary care physicians, but that only around 132 000 of these patients are well controlled. Thus, this study not only documents the enormous burden of hypertensive patients in the primary health system, but also highlights the alarming lack of BP control in the vast majority of hypertensive patients.


International Journal of Public Health | 2004

Leitlinienorientierung deutscher Hausärzte bei der Diagnostik und Therapie der arteriellen Hypertonie und des Diabetes mellitus

Nicole Wagner; David Pittrow; Wilhelm Kirch; Küpper B; P. Krause; Michael Höfler; Peter Bramlage; Hans-Ulrich Wittchen

SummaryObjectives:The paper examines to what degree German primary care physicians know and work along the rules established in guidelines for arterial hypertension and diabetes mellitus.Methods:HYDRA is a 2-stage cross-sectional point prevalence study with 1912 participating primary care settings throughout Germany including 45125 patients. A pre-study questionnaire to assess doctors practice patterns was used. Subsequently doctors completed a structured clinical appraisal with a diagnostic workup and characterization of the current treatments provided. All patients filled out a questionnaire.Results:Pre-study results show that only every second primary care physician manages the patients according to established guidelines. Further, physicians estimated their own work as problematic and not always successful. Guideline-oriented doctors were more likely to report hypertension and diabetes treatment patterns that also match guideline’s recommendations.Conclusions:The study shows a considerable degree of dissatisfaction with the quality of their work among primary care physicians. Guideline-oriented doctors however reveal more frequently formally adequate management characteristics. This encouraging aspect suggests the need of more successful implementation of medical guidelines in order to achieve improved evidence-based medicine and better patient-oriented health care.


Journal of Public Health | 2003

Der Arzneimittelgebrauch und die Compliance von Patienten mit Diabetes mellitus in der Allgemeinarztpraxis nach Arztangaben

Nicole Wagner; Ulf Maywald; David Pittrow; Hans-Ulrich Wittchen; Küpper B; Michael Höfler; P. Krause; Peter Bramlage; Wilhelm Kirch

ZusammenfassungZiel des Beitrages ist es, selbstreflektierte Einstellungsmuster von Hausärzten zur medikamentösen und nicht-medikamentösen Behandlung von Patienten mit Diabetes mellitus zu analysieren. Ärztliche Aussagen zur Patienten-Compliance werden in die Betrachtungen einbezogen, um Hinweise auf das Medikamenteneinnahmeverhalten der Patienten zu erhalten. HYDRA ist eine Punktprävalenzstudie mit Mehrstufen-und Mehrebenendesign, an der sich 1.912 Allgemeinarztpraxen in Deutschland beteiligten. An zwei Untersuchungshalbtagen wurden Datensätze von 45.125 Patienten erhoben. Als Messinstrumente wurden ein Vorbogen für den Arzt zur Beschreibung der generellen Praxiseigenschaften, ein Patientenfragebogen und ein Arztfragebogen zu den jeweiligen Erkrankungen, der neben patientenspezifischen Daten auch Laborresultate einschloss, eingesetzt. Die Ergebnispräsentation dieses Beitrags stützt sich maßgeblich auf Selbstaussagen der Arzte im Praxiserhebungsbogen. 84% der HYDRA-Studienärzte gaben an, dass ihre Kompetenz im Hinblick auf die medikamentöse Therapie des Diabetes mellitus ausreichend sei. Die von ihnen durchgeführte Arzneimitteltherapie des Diabetes mellitus entspricht gängigen Standards: Sulfonylharnstoffe und Metformin werden am häufigsten eingesetzt, Glitazone und Glinide deutlich seltener verordnet. Auch verschiedene nicht-medikamentöse Behandlungsstrategien wurden als bedeutsam erachtet Die Compliance der Patienten wurde von den HYDRA-Studienärzten in 36% der Fälle als nicht ausreichend eingestuft. Die Patienten mit Diabetes mellitus werden zum überwiegenden Anteil medikamentös behandelt Demgegenüber wird die Versorgungslage im Hinblick auf diätetische Maßnahmen und die Prävention fordernde Beratungsgespräche mit den Patienten als verbesserungsfähig erachtet Entsprechende Maßnahmen könnten die Compliance der Patienten verbessern.AbstractThe aim of the study was to analyse attitudes and patterns of general practitioners in Germany on the treatment of patients with diabetes mellitus as well as to evaluate general practitioner’s statements regarding patient compliance to their treatment. HYDRA is a cross-sectional point prevalence study with 1.912 primary care practices in Germany. Datasets of 45.125 patients were collected. Study instruments included a prestudy questionnaire for physicians to assess general characteristics of the GPs and their practices, a patient questionnaire with particular regard to hypertension and diabetes mellitus. At the same time, physicians described patient’s complaints, severity of the disease and defined further treatment procedures. Finally, laboratory data were also included. The presentation of results is based on self-ratings by physicians in the prestudy questionnaire. 84% of the participating physicians confirmed their own expertise concerning drug therapy of patients with diabetes mellitus. Drugs used were in accordance with the literature: sulfonylureas and metformin were most frequently administered; glitazones and glinides were less frequently given. Dietetic procedures were judged as important by the physicians interviewed. They, furthermore, assumed in 36% of the patients that their compliance was not sufficient According to physicians’ information given in the questionnaire, patients with diabetes mellitus received drugs predominantly. On the other hand the primary care with dietetics and prevention promotion with counselling interviews could well be improved. Corresponding arrangements could enhance the patient’s compliance.


Clinical Pharmacology & Therapeutics | 2003

Hypertension and diabetes screening and awareness study (hydra): Prevalence, comorbidity and pharmacological treatment patterns of hypertension and diabetes in primary care in Germany

David Pittrow; Wilhelm Kirch; Hans-Ulrich Wittchen; T. Unger; P. Krause; A. M. Sharma; E. Ritz; B. Goeke; Hendrik Lehnert; D. Tschoepe

Clinical Pharmacology & Therapeutics (2003) 73, P69–P69; doi:


The Journal of Clinical Psychiatry | 2002

Generalized anxiety and depression in primary care: Prevalence, recognition, and management

Hans-Ulrich Wittchen; Ronald C. Kessler; Katja Beesdo; P. Krause; Michael Höfler; Jürgen Hoyer


Psychological Medicine | 2002

Prevalence, incidence and stability of premenstrual dysphoric disorder in the community

Hans-Ulrich Wittchen; E. Becker; Roselind Lieb; P. Krause


International Journal of Obesity | 2004

Recognition and management of overweight and obesity in primary care in Germany

Peter Bramlage; Hans-Ulrich Wittchen; David Pittrow; Wilhelm Kirch; P. Krause; Hendrik Lehnert; Thomas Unger; Michael Höfler; Küpper B; S. Dahm; S. Böhler; Arya M. Sharma


Fortschritte der Medizin | 2001

[NISAS-2000: The "Nationwide Insomnia Screening and Awareness Study". Prevalence and interventions in primary care].

Hans-Ulrich Wittchen; P. Krause; Michael Höfler; David Pittrow; S. Winter; B. Spiegel; Göran Hajak; Dieter Riemann; A. Steiger; Hildegard Pfister


Nervenheilkunde | 2001

NISAS-2000 - die "Nationwide insomnia screening and awareness study". Insomnien und Schlafstörungen in der allgemeinärztlichen Versorgung.

Hans-Ulrich Wittchen; P. Krause; Michael Höfler; S. Winter; B. Spiegel; Göran Hajak; Dieter Riemann; David Pittrow; A. Steiger; Hildegard Pfister


Fortschritte der Medizin | 2003

[Aim, design and methods of the "Hypertension and diabetes screening and awareness" -- (HYDRA) study].

Hans-Ulrich Wittchen; P. Krause; Michael Höfler; Hildegard Pfister; Küpper B; David Pittrow; Peter Bramlage; Thomas Unger; Arya M. Sharma; Eberhard Ritz; Göke B; Hendrik Lehnert; Diethelm Tschöpe; Wilhelm Kirch

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Hans-Ulrich Wittchen

Dresden University of Technology

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Michael Höfler

Dresden University of Technology

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David Pittrow

Dresden University of Technology

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Wilhelm Kirch

Dresden University of Technology

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Peter Bramlage

Dresden University of Technology

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Katja Beesdo

Dresden University of Technology

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Küpper B

Dresden University of Technology

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