P. Muthukrishnan

A highly sensitive and selective electrochemical determination of non-steroidal prostate anti-cancer drug nilutamide based on f-MWCNT in tablet and human blood serum sample

A novel electrochemical sensor based on the functionalized multiwalled carbon nanotube (f-MWCNT) was successfully developed for the sensitive and selective determination of non-steroidal prostate anti-cancer drug nilutamide in tablet and blood serum samples. The f-MWCNT was prepared by the simple reflux method and characterized by the scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy, X-ray powder diffraction (XRD) and fourier transform infrared spectroscopy (FT-IR). Interestingly, the f-MWCNT was exhibited a superior electrocatalytic activity towards the anti-cancer drug nilutamide when compared with pristine MWCNT and unmodified electrodes. Besides, the electrochemical sensor was revealed an excellent current response for the determination of nilutamide with wide linear ranges (0.01-21μM and 28-535μM), high sensitivity (11.023 and 1.412μA μM-1cm2) and very low detection limit (LOD) 0.2nM. The developed electrochemical sensor was showed an excellent selectivity even in the presence of electrochemically active biological substances and nitro aromatic compounds. Moreover, it manifested a good reproducibility and stability. In addition, the f-MWCNT modified glassy carbon electrode (GCE) sensor was successfully applied for the detection of nilutamide in tablet and blood serum sample.

Phyto mediated biogenic synthesis of gold nanoparticles using Cerasus serrulata and its utility in detecting hydrazine, microbial activity and DFT studies

Green synthesis of Au-NPs using Cerasus serrulata (C. serrulata) leaves extract has emerged as a nontoxic and ecofriendly option, as compared to currently available chemical and/or physical methods and also Au-NPs act as both reducing and stabilizing agent. The developed Au-NPs were characterized with XRD, UV-visible spectroscopy, FTIR, SEM, TEM and chemical constituents of C. serrulata leaves extract after and before reduction of Au-NPs have been identified through GC-MS. TEM images confirmed that biosynthesized Au-NPs were spherical in shape and approximately in the range of 5-25 nm. The electrochemical results showed remarkable electrocatalytic activity of the Au-NPs-modified GC electrode in the detection of environmentally hazardous pollutant like hydrazine. The modified electrode exhibits a wide linear range 5 nM to 272 μM with low detection limit 0.05 μM. The fabricated sensor shows good selectivity towards other electroactive species as well. Thus the proposed sensor seems to be a potential candidate for developing a simple, rapid and cost-effective electrochemical sensor. The synthesized Au-NPs exhibited higher antibacterial activity against gram negative (Escherichia coli) than gram positive (Staphylococcus aureus) bacteria. DFT studies revealed that the coumarin (CM) present in the C. serrulata leaves extract demonstrated greater reducing and stabilizing properties compared to the properties of other compounds like butylhydroxytoluene (BHT) and hydrocoumarin (HCM) present in the extract.

Biosynthesis of silver nanoparticles by using Camellia japonica leaf extract for the electrocatalytic reduction of nitrobenzene and photocatalytic degradation of Eosin-Y

In the present study, sphere-like silver nanoparticles (Ag-NPs) were synthesized by using Camellia japonica leaf extract and its remediation industrial pollutants such as nitrobenzene and Eosin-Y (EY). As-prepared sphere-like Ag-NPs were characterized by various analytical and spectroscopic methods such as UV-visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), High-resolution transmission electron microscopy (HR-TEM), Energy dispersive X-ray spectra (EDX), and the chemical constituents of the leaf extract were also analyzed by using Gas chromatography and Mass Spectroscopy (GC-MS). Fascinatingly, the as-prepared sphere-like Ag-NPs exhibits excellent electrocatalytic and photocatalytic activity for the reduction of nitrobenzene and photo-degradation of EY dye respectively. The Cyclic voltammetry (CV) and amperometric (i-t) studies realized that the electrochemical behavior of sphere-like Ag-NPs modified electrode on nitrobenzene reduction. The proposed nitrobenzene sensor exhibited appreciable wide linear response range and low detection limit of 0.05-21μM, 23-2593μM and 12nM, respectively. The Ag-NPs modified electrode showed excellent selectivity towards the nitrobenzene detection even in the presence of common metal ions and nitroaromatic containing substances. On the other hand, Ag-NPs have excellent photocatalytic activity with >97% degradation of EY dye after irradiated 60min. These results indicated that the growth of sphere-like Ag-NPs should be a proficient.

Adsorption and corrosion inhibiting behavior of a new S-triazine derivative

AbstarctThe inhibiting effect of 4, 6-bis (5-mercapto-1, 3, 4-thiadiazol-amine)2-phenylamino-1,3,5-triazine BMTDT on the corrosion of mild steel in acidic media has been investigated by weight loss and electrochemical methods. Results obtained reveal that this organic compound is a very good inhibitor. BMTDT is able to reduce the corrosion of steel more effectively in 1M HCl than in 1 M H2SO4. The effect of polarization studies show that the adsorption of BMTDT follows physical adsorption in both acids without changing the mechanism of the hydrogen evolution reaction. Surface analyses were also carried out to establish the mechanism of corrosion inhibition of mild steel in acidic media. The adsorption of this inhibitor on the mild steel surface in obeys the Langmuir absorption isotherm in 1 M HCl and Frumkin adsorption isotherm in 1M H2SO4. The corrosion behavior of mild steel with addition of different concentration of BMTDT was studied in the temperature range 308–333 K. The associated activation parameters and adsorption free energies have been determined and discussed.