P. Naveen

Synthesis, xanthine oxidase inhibition, and antioxidant screening of benzophenone tagged thiazolidinone analogs.

A series of novel 2‐(diaryl methanone)‐N‐(4‐oxo‐2‐phenyl‐thiazolidin‐3‐yl)‐acetamides were synthesized by various Schiff bases of (4‐benzoyl‐phenoxy)‐aceto hydrazide with thioglycolic acid. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, mass spectra, and C, H, N analysis. Further, all the synthesized compounds 9a–n were evaluated for xanthine oxidase (XO) inhibition and antioxidant properties. Among all the tested compounds, 9f, 9m, and 9n demonstrated potent XO inhibition of 52, 76, and 26%, respectively, compared to the standard drug allopurinol, which is evident from in vitro and in silico analysis. On the other hand, compounds 9c, 9d, and 9k exhibit potent antioxidant properties.

5-(4-Meth­oxy­phen­yl)-1,3,4-oxa­diazol-2-amine

In the title compound, C9H9N3O2, the dihedral angle between the aromatic rings is 8.64 (10)°. The crystal structure features inversion-related dimers linked by pairs of N—H⋯N hydrogen bonds, generating R22(8) loops. A further N—H⋯N hydrogen bond links the dimers into (100) sheets.