P. Ramulu

Ahmed Kamal; P. Praveen Kumar; Kokkonda Sreekanth; B.N. Seshadri; P. Ramulu

The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines.

Ahmed Kamal; G. Ramesh; P. Ramulu; O. Srinivas; Tasneem Rehana; Gurrala Sheelu

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that possess cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.

Ahmed Kamal; O. Srinivas; P. Ramulu; G. Ramesh; P. Praveen Kumar

Synthesis of C2 and C2-C8 linked pyrrolobenzodiazepine-naphthalimide hybrids have been prepared that exhibit significant DNA-binding affinity and cytotoxicity.

Ahmed Kamal; P. Ramulu; O. Srinivas; G. Ramesh

The facile synthesis of C-8 methanesulphonate substituted pyrrolobenzodiazepines is described. These have been prepared by linking the methanesulphonate at C-8 position with alkanol spacer and their in vitro cytotoxicity have been described.

Ahmed Kamal; N. Laxman; G. Ramesh; O. Srinivas; P. Ramulu

The design and facile synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines is described. These have been prepared by linking the amines at C-8 position with propane spacer to improve solubility in water, and their in vitro cytotoxicity studies have been carried out.

Ahmed Kamal; O. Srinivas; P. Ramulu; G. Ramesh; P. Praveen Kumar

Ahmed Kamal; P. Ramulu; O. Srinivas; G. Ramesh

Ahmed Kamal; G. Ramesh; O. Srinivas; P. Ramulu

Ahmed Kamal; P. Ramulu; O. Srinivas; G. Ramesh; P. Praveen Kumar

Ahmed Kamal; G. Ramesh; O. Srinivas; P. Ramulu; N. Laxman; Tasneem Rehana; M. Deepak; M.S. Achary; H.A. Nagarajaram